Compassionate Use Trial of Innate Immunotherapeutics’ Multiple Sclerosis Drug Shows Positive Results

Compassionate Use Trial of Innate Immunotherapeutics’ Multiple Sclerosis Drug Shows Positive Results
0
(0)

Innate ImmunotherapeuticsAustralian biotechnology company Innate Immunotherapeutics’ trial for a drug designed to treat secondary progressive multiple sclerosis (SPMS) has produced positive results. Innate’s experimental MIS416 has revealed benefits to the majority of SPMS patients who were prescribed it as a “compassionate use drug,” given the total lack of treatment resources to fight the secondary progressive type of the disease.

Innate enrolled 24 MS patients in the trial, 15 of which had already participated in the Phase 1B and 2A trials of the drug. Out of the total patients being studied, 18 have SPMS and the other six suffer from a rarer primary progressive form of multiple sclerosis. Patients have been treated with the drug for 24 months, on average, receiving a median of 52 doses.

Although the new results cannot prove the safety or efficacy of MIS416 yet, the trial results can provide new insights into the course of treatment. According to the regular safety blood tests performed, the patients are able to receive weekly or fortnightly injections of MIS416 on a long-term and continuous basis, and there was no significant dose intolerance or cumulative toxicity reported.

SPMS causes walking, hand, eyesight and cognitive function disabilities, all of which are part of the study’s aim to test the viably of MIS416 as a treatment for Secondary Progressive MS. As part of the study, patients also reported their own health status quarterly, as the results have shown significant and sustained reductions in pain and fatigue.

[adrotate group=”4″]

The results of the trial may also aid Innate in future patient recruitment for the Phase 2B of the study.

Opexa Therapeutics, a Texas-based drug delivery company, is also developing a breakthrough T-cell immunotherapy for the treatment of SPMS. Tcelna has already reached its Phase 2B clinical trial, which is currently being conducted in 35 select clinics across the U.S. and Canada. Each patient will receive two yearly treatment courses of Tcelna composed of five subcutaneous injections, and researchers will measure the brain volume changes at the end of 24 months.

Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
×
Patrícia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.
Latest Posts
  • My MS Manager app, Selma blair
  • scans and disability measures
  • Zeke, a MyoPro user
  • MMJ Bioscience study request

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?