Mitochondria May Play a Role in MS Development and Progression

Mitochondria May Play a Role in MS Development and Progression
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Recent attention to the role of mitochondria in the etiology of multiple sclerosis (what causes the disease) suggests that mitochondrial defects and mitochondrial structural and functional changes may contribute to the disease. Researchers studying mitochondria in multiple sclerosis believe abnormalities in mitochondrial dynamics impact cellular pathways such as inflammation and demyelination, ultimately impacting patients with multiple sclerosis.

Dr. Peizhong Mao and Dr. P. Hemachandra Reddy, of the Neurogenetics Laboratory at Oregon Health & Science University, identified five key abnormalities in the mitochondria that are involved in disease development and progression. Mitochondrial DNA defects, abnormal mitochondrial gene expression, defective mitochondrial enzyme activities, deficient mitochondrial DNA repair activity, and mitochondrial dysfunction have been shown to play a role, according the two researchers’ article, “Is Multiple Sclerosis a Mitochondrial Disease?” that was published in Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease.

“Neurons are highly dependent on oxidative energy metabolism,” wrote Dr. Mao and Dr. Reddy. “Deficient mitochondrial metabolism may generate more reactive oxygen species (ROS) that can wreak havoc in the cell.” A recent study published in Neurology, entitled “Mitochondrial DNA Sequence Variation in Multiple Sclerosis,” demonstrated that certain mitochondrial genetic variants are associated with multiple sclerosis. For example, patients with haplogroup J variants were at a 1.5-times increased risk for developing primary progressive multiple sclerosis.

Another look into mitochondrial involvement in multiple sclerosis was conducted by Dr. Lukas Haider at the Medical University of Vienna. “Recent data indicate that mitochondrial injury and subsequent energy failure are key factors in the induction of demyelination and neurodegeneration,” wrote Dr. Haider in the article, “Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple Sclerosis,” which was published in Oxidative Medicine and Cellular Longevity. Since the brain accounts for such a large proportion of oxygen consumption in the mitochondria, cells in the brain are especially susceptible to oxidative stress, leading to the previously identified genetic variants as a result of damage. Without properly functioning mitochondria, cells within the brain cannot thrive.

Dr. Mao and Dr. Reddy discussed a few therapeutic approaches to treat multiple sclerosis by targeting the mitochondria. These therapies are considered more neuroprotective than immunomodulatory and are different from current treatments for multiple sclerosis. Inhibitors of proteins that allow oxidative stress to damage the mitochondria, such as intravenous mitoxantrone, might delay the progression of multiple sclerosis in relapsing-remitting or secondary progressive multiple sclerosis.

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