January 16, 2024 News by Andrea Lobo, PhD EU agency OKs study of therapy to improve mitochondrial function Mitochon Pharmaceuticals is launching a pilot clinical trial to evaluate MP101, its treatment candidate for improving mitochondrial function, in people with multiple sclerosis (MS) and other neurodegenerative diseases. The announcement follows the trial’s clearance by the European Medicines Agency (EMA), which enables Mitochon to begin enrolling patients with…
February 23, 2023 News by Lindsey Shapiro, PhD Mitochondria changes found early on in progressive MS: Mouse study Changes in mitochondria ā cells’ energy production centers ā are evident in early disease stages in a mouse model of progressive multiple sclerosis (MS), but were not found in a model of relapsing-remitting MS (RRMS), according to researchers. These changes, seen before symptoms of the disease started, were…
December 29, 2020 News by Marta Figueiredo, PhD Top 10 Multiple Sclerosis Stories of 2020 Multiple Sclerosis News Today brought you daily coverage of the latest scientific findings, treatment developments, and clinical trials related to multiple sclerosis (MS) throughout 2020, a year marked by theĀ COVID-19 pandemic. We look forward to reporting more news to patients, family members, and caregivers dealing with MS during…
June 30, 2020 News by Patricia Inacio, PhD Boosting Cellular Energy at Sites of Myelin Loss May Stop MS Progression Loss of myelin in nerve cell fibers ā the hallmark of multiple sclerosis (MS) ā leads to a shortage ofĀ mitochondria, a cell’s powerhouse, denying these damaged fibers the energy they need to work as intended, a new study shows. Boosting the migration of mitochondria to affected nerve…
February 27, 2020 News by Forest Ray PhD Cellular Metabolism Could Be New Therapeutic Target in MS, Study Suggests Immune system cells can either trigger or suppress inflammation by controlling mitochondrial respiration ā the process that occurs in mitochondria, the cells’ powerhouses, and results in the production of usable energy by cells ā according to a recent study. This discovery raises the possibility that…
July 18, 2019 News by Ana Pena PhD Specific Lipids in Cerebrospinal Fluid of Progressive MS Patients Rob Neurons of Energy, Study Finds The cerebrospinal fluid (CSF) of people with progressive multiple sclerosis (MS) contains elevated levels of specific fatty molecules that disrupt the energy “powerhouses” of nerve cells, and appear to underlie the neurodegeneration seen on brain scans of these patients, a study reveals. The research, which compared the CSF…
November 30, 2017 Columns by Tamara Sellman The MS Alphabet: Mimic, Marcus Gunn Pupil, Mitochondria, and Other ‘M’ Words Editorās note: Tamara Sellman continues her occasional series on the MS alphabet with the second of two columns about terms starting with the letter “M.” Symptoms of MS Marcus Gunn pupil This is a sign of emerging MS that may be discovered during what is known as the…
August 18, 2017 News by Patricia Silva, PhD GeneFo and MitoQ Plan Webinar on How Mitochondrial Antioxidants May Impact MS The online multiple sclerosis community GeneFoĀ will hold a webinar next week to discuss the latest research findings on how mitochondrial antioxidants may affect MS. The webinar, which will be open to patients who register, will start at 1 p.m. U.S. Eastern Standard Time on Thursday, Aug. 24. GeneFo…
March 28, 2017 News by Joana Fernandes, PhD Increased Rab32 Protein Levels May Be Involved in MS Progression, Canadian Study Finds HighĀ levels of a protein called Rab32 may contribute toĀ the progression of multiple sclerosis (MS), leading to neuronal loss, a new study concludes. The study, āRab32 connects ER stress to mitochondrial defects in multiple sclerosis,ā appearedĀ in the Journal of Neuroinflammation. The endoplasmic reticulum (ER) is involved in the production…
June 21, 2016 News by Patricia Silva, PhD GeneFo Partners with MitoQ to Offer Energy Supplement at Discount to MS Community GeneFo, a social-medical community that connects patients with multiple sclerosis (MS) and offers free in-house medical consulting, recently announced a partnershipĀ withĀ MitoQ, a New Zealand-based company focused on mitochondrial health. MitoQ is a mitochondria-targeted antioxidant supplement thatĀ mayĀ help to alleviate common symptomsĀ in MS. MS, a chronic disease of the central…
June 9, 2016 News by Patricia Silva, PhD #CMSC16 – Metabolism in MS and the Role of Mitochondrial Dysfunction One June 3, a workshopĀ titled āMetabolism in MS and Related Conditionsā was presented at the 2016 Annual Meeting of the Consortium of Multiple Sclerosis Centers (CMSC), heldĀ June 1-4 in National Harbor, Maryland. One of the speakers was Dr. David Sheikh-Hamad, professor of medicine-nephrology at Baylor College of…
March 23, 2016 News by Patricia Silva, PhD High Lactate Levels in MS Patients Tied to Disease Progression, Mitochondrial Dysfunction Scientists in recent years have wonderedĀ whether a link exists betweenĀ high lactate levels resulting from mitochondrial dysfunction andĀ multiple sclerosis (MS) progression. Now researchers in Italy showed that lactate, a metabolic byproduct, is indeed increased in the cerebrospinal fluid of MS patients andĀ may beĀ a disease driver. Mitochondria are the bodyās energy factories,…
December 28, 2015 News by Patricia Silva, PhD Top 10 Multiple Sclerosis Articles of 2015 Multiple Sclerosis News Today has reported the latest therapies, clinical trial developments, and events in multiple sclerosis (MS) on a daily basis throughout the past year. As 2015 comes to an end, hereĀ are the year’s 10 articlesĀ most widely readĀ byĀ Ā Multiple Sclerosis News TodayĀ readers, each with a brief summary of the developments…
December 21, 2015 News by Patricia Inacio, PhD MS Active and Inactive Lesions Differ in Levels of Enzymes that Drive Glucose Metabolism A research team recently showed that key enzymes of energy metabolism pathways are differentially expressed in active and inactive multiple sclerosis (MS) lesions, and may contribute to axonal degeneration in MS. The study, titled āDifferential expression of glucose-metabolizing enzymes in multiple sclerosis lesions,ā was published in the…
July 8, 2015 News by Maureen Newman Mitochondria May Play a Role in MS Development and Progression Recent attention to the role of mitochondria in the etiology of multiple sclerosis (what causes the disease) suggests that mitochondrial defects and mitochondrial structural and functional changes may contribute to the disease. Researchers studying mitochondria in multiple sclerosis believe abnormalities in mitochondrial dynamics impact cellular pathways such as inflammation and…
June 22, 2015 News by Patricia Silva, PhD Animal Models Offer New Insights Into Energy Metabolism in Multiple Sclerosis Researchers atĀ United Arab Emirates University in Abu Dhabi have recently published in the journal BMC Neuroscience new insights into the involvement of mitochondria and energy metabolism in the pathology of multiple sclerosis (MS) in rats. The study is entitled āBioenergetics of the spinal…