New Study Unravels How Myelin is Repaired, May Suggest New MS Treatments

New Study Unravels How Myelin is Repaired, May Suggest New MS Treatments

Japanese scientists have discovered new information about how the myelin sheath is repaired following damage. Myelin is a fatty substance that wraps around nerve cells and helps them to conduct impulses. The research could have major implications for how multiple sclerosis is understood and even treated. The study, titled Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells,” appeared in the Journal of Neuroscience on Sept. 2, 2015.

The symptoms of multiple sclerosis are due to an immune attack on the body’s own myelin. When myelin is lost around nerve cells, this can cause unpredictable loss of movement, sensation, vision problems and feelings of pain. Myelin is made by special nervous system cells called oligodendrocytes. Although it is well-known that myelin can be repaired by oligodendrocytes if it is damaged, scientists do not understand the exact repair mechanisms used by these cells. In MS, myelin unfortunately does not appear to be easily repaired, also for unknown reasons.

The researchers, led by Professor Masaharu Noda and colleagues of the National Institute for Basic Biology, wanted to study how myelin is repaired in mice with an experimental form of MS, induced by the myelin-damaging drug cuprizone. They studied both normal mice and genetically altered mice that lacked the protein tyrosine phosphatase receptor type Z (PTPRZ), which is a protein that may cause oligodendrocytes to turn into mature cells, rather than stay in a more immature stage.

RELATEDNew Multiple Sclerosis Drug May Repair Nerve Demyelination

Following loss of myelin with cuprizone, the mice that lacked PTPRZ had more myelin repair than the normal mice. The researchers also found that a protein called pleiotrophin (PTN), seemed to be associated with remyelination in the mouse brains, suggesting that it may inactivate PTPRZ. When studied in vitro (in a dish), oligodendrocytes treated with PTN turned into a form that creates new myelin.

Overall, the study suggests that pleiotrophin is secreted by nerve cells when they are damaged and lose myelin, and pleiotrophin then inhibits PTPRZ. This allows oligodendrocytes to create new myelin.

The new understanding of how myelin is formed could provide the basis for new MS treatments, for example, drugs that inhibit PTPRZ or that increase pleiotrophin might be used in the future. Of course, much more research is needed and the investigators will need to find new compounds that act on PTPRZ.

According to Noda “This achievement was made possible by establishing oligodendrocyte precursor cell lines. Pleiotrophin is an endogenous PTPRZ inhibitor, but if synthetic PTPRZ inhibitors were obtained, then effective treatments for multiple sclerosis should become possible. We are currently directing our research in that direction.”

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  1. Waverly says:

    As I am once again laying down taking an afternoon break~~~Thrilled to read about the latest Mylan studies.
    I’d give anything to help forward this and it helps knowing it’s another building block to Fight MS.!
    Thank you, Thank you, Thank you,
    10+ yrs MS

  2. Waverly says:

    As I take another afternoon break& lay down to rest my legs & feet.
    Thrilled to read about the latest with Mylan studies.
    I would give anything to help forward this movement.
    It’s another building block fighting MS.
    Thank you, Thank you, Thank you
    10+ MS yrs.

  3. Judy Lee says:

    This is wonderful news and looks like steps in the right direction. I volunteer to be a guinea pig anytime!!!!!!
    Judy Lee
    8+ MS years

    • I was diagnosed in November of 1986. I try to eat right, fruit, vegetables & lean protein. No processed foods!
      I try to stay away from junk food also.
      The medicine made me worse. I haven’t taken any m.s. drugs for 4 years. My last mri showed no changes. I also take whole food pills. They have worked so well that my husband & I became distributors.
      What works for 1 doesn’t always work for everyone.
      The Adkins diet was made up by a Dr. who was bedridden because of MS. Through trial & error she came up with the Adkins diet & now runs marathons!

      • MDS says:

        This is so encouraging. I’m going for my first MRI soon. Many of my symptoms point towards MS. I’m horribly overweight. Yesterday was a rough day with internal waves of vibrations. I read about green tea, broccoli,green leafy vegetables,& other helpful foods. Last night & today I ate & drank the foods jyst listed.Today I only experienced heavy arms & head & only a short, slight headache, none of which last all day. I don’t know if the food helps that quickly but I’m willing to try.
        Thank you so much for sharing.

        • Fon Drees says:

          Internal waves of vibrations, is that a symptom of M.S.? I dont niw about waves, but from time to time I feel like my whole insides are vibrating. It lasts for a couple hours or a couple days. Then goes away.

      • Gine says:

        I love it, just dropping all the medications has crossed my mind, I have had MS for 20years. I have had a normal happy day life, until recently have had seizures these past couple of years. My doctor is telling me it’s due to the MS. Never having a seizure before in my diagnosis would this be possible, Or would it be from my most current medication on now TECFIDERA. Reading on possible side effects, it may have seizure side effect on me how do I research this question I have. My doctor, is a specialist in MS.
        Well known Neurologist in the MS world. Yet I know and have met friends associates who have or have many of the same systems when I was first diagnosed, and are not on any medications today? However live a happy healthy life just eating healthy, , and avoiding stress. Please advise and thoughts on all.

        good reputation and knowledge

  4. fran says:

    Very exciting news. How many years do we need to get this in clinical trial. Don’t want to get so excited its gonna take years until something happens.

  5. Bucca says:

    I was Dx in 1990 and was told then that “they” were very close to finding a cure – NOT!!! I had every symptom of MS at one time or another but always recovered. Approx. 7 yrs ago it changed and I lost my ability to walk. I was wondering if anyone has an idea of regaining a loss with stem cell transplant?

    • Lisa DeGraw says:

      There are new stem cell studies from doctors in Ottawa. Ottawa doctors behind breakthrough multiple sclerosis studyOttawa doctors behind breakthrough multiple sclerosis study.Alex Normandin was in 3rd year medical school when he underwent a risky treatment for aggressive multiple sclerosis as part of an experimental trial led by the Neuro. He’s photographed at home on March 29, 2013. Scans show no new brain lesions and a marked improvements of symptoms associated with the disease

    • Gloria says:

      Hi the best thing Will be cannabis oil. In Barcelona and Colombia is legal and cheap. My daughter has ms and she is living in Barcelona to help herself with ms.. 07771757227 gg

      • N.Powell says:

        Thank you- I have heard that the oil is doing wonders for many diseases. I wish it would become medically legal in every state. Big pharma has such control over government it’s crazy, they’d rather we poison our bodies with their over priced Rxs.
        Glad to hear your daughter has found a way to help her MS.

        • Judy says:

          CBD oil helps me with pain when I can afford it to buy it. As you may know, there are lots of different qualities of CBD oil on the Internet and we all may respond differently to it. For British residents, so far I like In the US there is so much available. Erin Elizabeth (Dr. Mercola’s partner) recommends SOLCBD. It helped her. Neither of us are affiliates, so no money is being made.

      • Andrea says:

        I watched mama rosa on you tube who has helped with my diet in repairing nerves and the myelin . God and ourselves are the only ones we can trust to heal ourselves.

  6. Huri says:

    Now for some different concern:
    As an MS patient watching socalled MS research since 30 years I often wonder how many millions of creatures who have a central nervous system and therefore can feel pain are tortured crippled and finally killed(called neutrally “animal or mice model”) in the name of “research” in order to arrive at some insignificant conclusion that cannot be replicated in human beings? Not in my name please.

    • Sarah says:

      Yes. I agree. I have “demyeliniation” which is being observed and no definitive diagnosis yet because I’m in denial still. But I am a vegetarian and abhor the barbaric, tortuous and inhumane reality of animal testing. It pains me more than knowing something is in store for me. So, as I believe in the philosophy of ” live and let live”, I have decided to not get diagnosed as I don’t need to worry, anxiety, speculation. If I can I’ll eat well, continue my healthy vegetarian diet and no “acidic food” will pass these lips as it’s all inflammatory inducing.

      • Phil says:

        I have GBS and demyelamination in my sensory nerves over 70% of my body.

        Make sure to add B12 Methylcobalamin to supplement since you’re not taking in high quality grass fed meats.

        I’m going healthy Keto and eating 8-10 cups of veggies per day while reducing my sugars to 20 g or less. It’s really helped my recovery.

    • Fon Drees says:

      Kale and spinach? Kale especially is hard to digest and is an immune and metabolism depressant.more of a super poison leading to blood clots. Good for sheep and cows if eaten in moderation. But they have several stomachs with which to digest it.

    • Fon Drees says:

      Perhaps we should experiment on you instead. I doubt that these researchers are the sadistic greedy people u imply them to be. Each experiment leads to a little more knowledge toward the ultimate goal. These mice blnever even would have been born, were it not for the research

  7. Julia Brown says:

    ….could this any any way possible cover myelin sheath repair in cases of Trigeminal Neuralgia? Having exhausted most meds and 2 unsuccesful brain surgeries,I live in absolute agony.

  8. Sean says:

    Anyone looking at the Chlamydia pneumoniae combination antibiotic thesis? Aka the Wheldon protocol, derived from research at Vanderbilt university. Anecdotal reports claim improvement in many cases. It obviously turns MS research on its head, indicating MS has a bacterial cause that is difficult to eradicate. To corroborate this finding, a new drug is being developed now in clinical Phase II trials that is just a combination of 3 already existing antibiotics, again with good results. The Wheldon protocol uses inexpensive and well tolerated antibiotics such as doxycycline, Azithromycin and tinidazole, and also recommends restorative supplements. N-acetyl cysteine is also used to eradicate the cyst form of Cpn as a preference over amoxicillin. Worst case the TB Rifampin drug is used.

    • Robert Millburn says:

      I agree, I’ve watched a great video with Dr. Wheldon:
      He thinks he’s found a cure for MS, aimed at eradicating the Chlamydia pneumoniae infection. When I presented this to my Neuro, he agreed, there has been a theory that this is infection based that has been around for quite sometime, but “they” say they need more data. I basically said the same thing Wheldon said in the interview, all of these antibiotics are off patent, and there’s essentially no profit to be made of this course of treatment. To my, and wife’s surprise, he actually agreed. This make me sick, that money and profits over people come first. I used to never be this way until I was diagnosed with MS, as of Aug 2016. I’m determined to fight this disease as much as I can, haven’t started any treatments yet. My first (local) Neuro wanted me on Tysbri, no thank you, risk of PML was too great. Got 2nd opinion from Georgetown MS Center, wonderful Doctor, gave me many options. Currently taking daily: B12 20k mcg, Glutathione 500mg, Protandum, Tumeric/Cucumin Extract 1000mg, D3 10k IU, Folic Acid 1000mcg, Optimized Curcumin 400mg, Chlorella Algae 3000mg. My new Neuro also said to start taking Biotin 5000mcg and Flaxseed oil. currently have gone to basically all fruits and veggies diet. So far so good.

    • Beth Walker says:

      Did you receive any responses re: anyone try protocol and experienced good Results ? I can’t help but believe there is a “fix” for ms that is safe effective and economical-

  9. Hema Malini says:

    My son got affected with acute demilinating encephalitis and he can’t move his left leg. Is there any medical treatment available to cure it fully and to recover fully. Pl. Suggest

  10. Gruggi says:

    I sympathise with all MS sufferers. I was diagnosed with PPMS in April of this year. I don’t smoke or drink or take any drugs or medication….so to be told this I was furious. I’ve researched everywhere in vain so I’m just going to feast on unsalted nuts, fruit smoothies with lots of Kale and Spinach until my next M.R.I in October. Stuff ’em.
    Take care everyone.

    • Rob says:

      Hello Gruggi,

      I completely understand where you’re coming from. i too led a fairly healthy lifestyle, no drinking, never smoked ever, no drugs, and when I was diagnosed, I was devastated to say the least. I too stick to a low salt, no saturated fats, essentially the overcomingms diet on
      Not wanting to take any of the pharmaceutical poisons for the rest of my life, I researched, and now subscribe to the Coimbra protocol. I’ve been on it for almost a year with fantastic results! As of my last MRI in March, two lesions on my spinal cord have shrunk, one significantly, and another on my brain has completely disappeared! I’m not saying it’s a cure, I’m not smart enough for that, but it’s a helped thousands of people around the world. You’ll never hear the pharma companies talk about this, because there’s no profit in it.
      Good luck on your journey.

  11. Lionel Barnet says:

    I’m interested in knowing whether anyone has considered the recent treatment options for MS to aid a person with Guillain Barre Syndrome, where the myelin sheath covering the nerves has been damaged. If the recent Japanese studies show promise for MS sufferers maybe they could also work for GBS patients. What do you think?

  12. Lynn Johnson says:

    I am investigating, for 20 thousand dollars I can have my
    stem cells removed and have my cells put back in me in hopes my myelin sheath can repair itself, does anyone have info about this procedure for MS patients who hope to walk again.

  13. Syed Yasir Ahmed Shah says:

    I m a patient of C.I.D.P. I live in Karachi – Pakistan.
    According to doctors in my country “there is no cure of C.I.D.P”.
    I don’t ve touch feeling sence at my entire body. My muscles are numb & weak. I m unable to do any work.
    Please help …
    I will be present my self as volunteer if doctors need for experiment.

  14. Sam says:

    I don’t know if this will cure, but this myelin sheath damage IS caused my EMF (such as WIFIs in our offices and neighbors). look up pubmed studies. Could myelin damage from radiofrequency electromagnetic field exposure help explain the functional impairment electrohypersensitivity? A review of the evidence.

    Long-term exposure to 835 MHz RF-EMF induces hyperactivity, autophagy and demyelination in the cortical neurons of mice

  15. Shawn says:

    I have PPMS, very bad yes, had it for a long time undiagnosed for 10 years at least. Now Disabled and worry about flare-ups constantly. I wonder if they have thought anymore about Nanite repair. Id be more than happy to test as I have a great understanding of Nanotech and the possibilities of Nanotech medically.

  16. Georgia B. says:

    If there’s the slightest chance of finding a cure, or better life for any and everyone affected by this disease it should be available to all ASAP. Personally having this disease, waiting, praying, something will happen with a cure. I also believe it can be cured. If we can send people to the moon, walking, and discovering there, new life there as I hear on the news. We should be not only embarrassed, but ashamed as the leaders of this country.


    Rethink MS
    For seven years I was experiencing off and on, hands and feet tingling, burning, pain, difficulty walking, extreme fatigue and depression. Countless visits to the ER and Dr. Office,checking for everything but B12. It then started where I had extreme difficulty getting dressed, had trouble feeding myself, could not write or hold a pen. Bending my neck sent electric shocks thru my body. Went to the hospital for MS testing. MRI, spinal tap, brain scan. After more testing, one Dr. checked my B12 level, it was 80. I spent 10 days in the hospital and 10 days in rehab. They were not sure if I would recover. Left untreated, B12 deficiency can cause permanent brain damage. I was lucky, everything reversed. Maybe if B12 METHYLCOBALAMIN were given early on, we might be able to help prevent MS and other brain and nerve related diseases.
    If that one Dr. didn’t check my B12 level,I would have been misdiagnosed with MS, because the symptoms are the same.
    B12 is vital for our health. It helps make DNA & RNA, your red blood cells.
    Helps with Depression,Dementia,Sleep Disorders.
    Helps with sleep-wake rhythm disorders (Circadian)
    Protects &a rebuilds the Myelin sheath covering your nerve fibers.
    Slows brain shrinkage up to 80%.
    Lowers Homocysteine levels associated with heart disease.
    If low levels are left unchecked, brain damage will occur and can become permanent.
    Helps with age related macular degeneration.
    By supplementing with sublingual Methylcobalmin B12 around 40 or 50 years of age, we could help prevent problems before they start.
    Everyone should supplement and maintain blood levels of B12 in the range from 600 to 2000 pg/ml in order to avoid and, if this is the case, help recover from the wide range of problems that result from B12 deficiency or insufficiency. Health care practitioners: this is the first thing you should check for every patient that comes in, independently of their age or condition

    Methylcobalamin: This is the neurologically active form of B12. It is technically a `coenzyme` of vitamin B12 and it is almost never prescribed by doctors despite being effective, readily available and inexpensive. It is also available in an injectable form. Degenerative neurological conditions are where methylcobalamin shows its greatest benefits over other cobalamin preparations. Brilliant news for MS’ers! Not only has Methylcobalamin been shown to work in neurologic diseases, it also helps with the elimination of toxic substances in the body.

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