MS and Young Adult-onset Hodgkin Lymphoma May Share Underlying Causes, Study Says

MS and Young Adult-onset Hodgkin Lymphoma May Share Underlying Causes, Study Says

Previous studies suggested that multiple sclerosis (MS) and Hodgkin lymphoma might share underlying causes, including exposure to microorganisms in childhood, such as Epstein-Barr virus (EBV) infection. In the study “Multiple sclerosis and risk of young-adult-onset Hodgkin lymphoma,” published in the journal Neurology: Neuroimmunology and Neuroinflammation, researchers suggested that common inherited or acquired risks for these conditions do exist.

Hodgkin lymphoma has three age-defined phenotypes, but it was the specific stage of young adult-onset Hodgkin lymphoma (YAHL) that was reported to be associated with a pattern of childhood markers of infectious exposure, and linked to MS.

The research team investigated if MS is associated with YAHL but not with the other Hodgkin lymphoma phenotypes. A cohort of 29,617 Swedish patients with an MS diagnosis (between 1968 and 2012) , and a control group of 296,164 people without MS, were used.

After being adjusted for participants’ age/period, sex, county of residence, and education level, results suggested that the association between MS and YAHL does exist, and most notably in female patients. Specifically, researchers found four patients with YAHL among the MS cohort, and 16 in the non-MS cohort. All four diagnoses of YAHL in MS occurred in women. The researchers, however, noted this may be due to the fact that most MS patients in the cohort were women, or because of sex-specific differences in susceptibility to a risk for both diseases.

A major study limitation was the inability to identify specific childhood exposures that underlie the association between MS and YAHL, the researchers said. Moreover, they had no access to potentially relevant personal characteristics that may influence disease association. Despite the large cohort number, the number of people with both MS and YAHL was found to be very small. This reflects the rarity of Hodgkin lymphoma in MS, and how the underlying risks for both diseases are not likely to be identical, though common factors are involved.

Researchers concluded that YAHL and MS may share common risks. Although unable to identify the risks, the team believes they may include the previously reported pattern of exposure to microorganisms in childhood.


  1. Liz says:

    My husband had Hodgkins Lymphoma at the age of 40 and a few years later I was diagnosed with MS…..Any correlation?

  2. Theresa says:

    My mother was diagnosed at she 32 with Hodgkins and I was just diagnosed with MS last year at age 35. We both resided in Charlotte, away from the rest of our family from her age of 23 and me being an infant. I’ve never had EBV to my knowledge. Is this something you can test for?.. I assume since it’s a virus? I wonder if I should be on antivirals.
    Thank you for this article! Def something to research!

  3. Shasha says:

    Hi, Yes…MS and Hodgkin Lymphoma and much more can be due to Celiac. Gluten may hurt intestines so less nutrients absorb…then cells are not made right to work right and malfunction and are low in oxygen burning. Gluten may lower the immune system. A MS person may have many health issues in addition to MS due to Celiac like low thyroid/clotting disorders/Diabetes/fibromyalgia/stomach and intestines hurt/depression and much more. 10 health issues may kick in due to untreated Celiac.

  4. Robin O'Bannon says:

    According to Author and Medical Medium Anthony William, there is a reason that so many of these “mystery” illnesses overlap. It IS viral, it is NOT in your head and all of these often debilitating, autoimmune issues of “unknown etiology” are all related and have the same underlying cause and mainstream medicine is about 20 years behind in figuring it out. Medical Medium by Anthony William. A small investment for real results.

  5. Stacy says:

    I was dx with MS 2006, took Tecfider starting June 2012. Dx with Nodular Lymphocyte Predominant Hodgkins Lymphoma at age 44 in June 2016. Taken off of Tecfidera and started radiation for cancer. As of Dec 2016 cancer in remission.

    • Nichole says:

      Hi I was wondering if we could speak?? I am on tecifidera for over a year not long after stared taking it I got this weird rash. After over a year of Derm saying an infection and neurologist denying tecifidera had any involvement they are now doing biopsies for lymphoma. I do not think it was a coincidence. Was wondering if you ever felt same way? What were your first symptoms?

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