News Myelin-Producing Brain Cells Seen for 1st Time to Be Highly Diverse and Specialized Myelin-Producing Brain Cells Seen for 1st Time to Be Highly Diverse and Specialized by Patricia Silva, PhD | June 17, 2016 Share this article: Share article via email Copy article link Oligodendrocytes ā brain cells that wrap themselves around neurons to produce myelin ā are much more diverse than previously believed. ScientistsĀ in Sweden, using a newĀ type of sequencing, have discovered more thanĀ a dozen different kinds, including anĀ oligodendrocyte subtype involved in motor learning, a finding that might spur new research into protecting against the loss of motor skills in multiple sclerosis (MS). Researchers in the study,Ā āOligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system,āĀ made use of a new sequencing method that has revolutionized the way we view cellular processes. Earlier studies had to contend with visual differences between cells, or studies of individual gene transcripts ā rather blunt tools, it turned out. But a powerful sequencing technique called single cell RNA sequencing now allows scientists to takeĀ a snapshot of what a particular cell is doing, mirrored by the activity of all its genes. Up to now, researchersĀ have viewed oligodendrocytes as one cell type, belonging to a class of brain cells called glia, with a main responsibility to produce the myelin that insulates nerve processes inĀ axons. Sueli Marques, left, the study’s first author, with Sten Linnarsson and GonƧalo Castelo-Branco. (Photo courtesy, Ulf Sirborn, Karolinska Institutet) Drs. GonƧalo Castelo-Branco and Sten Linnarsson at the Karolinska InstitutetĀ led a team of researchers inĀ applying the method to more than 5,000 individual cells from different parts of the brain and spinal cord in both young and adult mice. What they found was surprising. āWe uncovered an unexpected diversity within the oligodendrocyte population,ā said Professor Linnarsson in a press release. āIn this study, we have identified 12 subclasses of oligodendrocytes and a novel cell distinct from oligodendrocytes residing in the blood vessels.ā Interestingly,Ā the cells did not start outĀ so distinct. In adolescent mice, the researchers foundĀ littleĀ difference betweenĀ theĀ cells inĀ various parts of the central nervous system. But as the mice grew older, the oligodendrocytes became more specialized, a finding the scientists described in their report, publishedĀ in the journalĀ Science. āThe uncovering of this unexpected oligodendrocyte diversity might bring new insights on mechanisms of degeneration and regeneration of diseases where myelin is lost, such as multiple sclerosis,ā Dr. Castelo-Branco said. The oligodendrocyte subtype found to be involved in complex motor learning was particularly rapid in its myelination activity, making it a suitable target for studies on myelination disorders such as MS. Print This Page About the Author Patricia Silva, PhD PatrĆcia holds a PhD in medical microbiology and infectious diseases from the Leiden University Medical Center, Netherlands, and completed a postdoctoral research fellowship at the Instituto de Medicina Molecular, Lisbon, Portugal. Her work in academia was mainly focused on molecular biology and the genetic traits of infectious agents such as viruses and parasites. PatrĆcia earned several travel awards to present her work at international scientific meetings. She is a published author of several peer-reviewed science articles. Tags diversity, myelin, oligodendrocyte
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