News Migraine and Other ‘Common’ Ills Being Mistaken for MS, Study Finds Migraine and Other ‘Common’ Ills Being Mistaken for MS, Study Finds by Joana Fernandes, PhD | September 8, 2016 Share this article: Share article via email Copy article link Patients with a number of commonĀ conditions ā some neurological and some autoimmune, but others not ā are being mistakenly diagnosed with multiple sclerosis (MS) because of difficulties in correctly determining this disease and, possibly, pressure to begin treatment early in the disease’s course, according toĀ a recent study published in the journalĀ Neurology. āAlthough many rare disorders are known to mimic MS, it appears that presently, a number of common disorders are frequently mistaken for MS,ā Andrew Solomon,Ā MD, from the University of Vermont and the study’s lead author,Ā said in aĀ news release. Several factors likely contribute to this problem, such as the lackĀ of specific disease markers orĀ blood tests to diagnose MS, the combination of different genetic and environmental factors responsible for the development of the disease, and the wide range of symptoms associated with the nerve damage observed in MS patients. In the study, “The Contemporary Spectrum Of Multiple Sclerosis Misdiagnosis,” Ā Solomon and colleagues ā all MS specialists working atĀ four MS academic centers in the U.S. (University of Vermont, Mayo Clinic, Washington University, and Oregon Health & Science University) ā pooled data on people they found to beĀ wrongly diagnosed with MS. Specifically, the neurologistsĀ identified 110 peopleĀ either “definitely” (51 patients) or “probably” (59) misdiagnosed. OfĀ these, 73 patients had one of five conditions: migraine (alone or in combination with other problems), fibromyalgia, an abnormal MRI (magnetic resonance imaging, a test widely used in MS diagnosis) with Ā nonspecific or nonlocalizing neurologic symptoms, a psychological condition, or neuromyelitis optica spectrum disorder (a disease that induces damage to the optic nerves and spinal cord). As a consequence of the misdiagnosis, 72% of the patients were incorrectly medicated ā treated for MS ā sometimes taking MS medications for āmanyā years. This is relevant, becauseĀ some MS treatments can haveĀ serious side effects. Moreover,Ā 33% of the patients remained misdiagnosed for at least 10 years before being informed they did not have MS by the researchers. Four patients without MS had alsoĀ enrolled in clinical trials for experimental MS therapies.Ā In addition, the researchers reported that in 79 patients (72%) there was anĀ earlier opportunity to make a correct diagnosis. āOne drug, which 13 percent of the misdiagnosed patients took, can cause a potentially fatal brain infection,ā Solomon said. āOther patients suffered from the discomfort and inconvenience of daily injections, others experienced side effects from medications, and finally, they lacked treatment for their actual correct diagnoses.ā Misinterpretation orĀ misapplication of MS diagnostic criteria can contribute to anĀ incorrect diagnosis, the researchers said. The criteria include the accurate interpretation of symptoms, physical examination, and radiological tests, such as MRI. However, because MRI may not always provide a clear and definiteĀ result, it is important that clinicians fully consider a patient’sĀ entire history, symptoms, and examination results before committing to an MSĀ diagnosis. āThere is pressure to make the diagnosis of MS early, and to start patients on MS therapies quickly,ā said Solomon. āBut in some patients who do not meet our diagnostic criteria, waiting longer and following them closely may help determine the correct diagnosis.ā The authors hope their study will helpĀ to increaseĀ awareness aboutĀ the challenges in correctly diagnosing MS, leading to better physician education, and encourage further study into possible misdiagnoses. Print This Page About the Author Joana Fernandes, PhD Joana brings more than 8 years of academic research and experience as well as Scientific writing and editing to her role as a Science and Research writer. She also served as a Postdoctoral Researcher at the Center for Neuroscience and Cell Biology in Coimbra, Portugal, where she also received her PhD in Health Science and Technologies, with a specialty in Molecular and Cellular Biology. Tags fibromyalgia, migraine, misdiagnosis, MRI
April 18, 2024 Columns by Benjamin Hofmeister Learning how to write a ‘SOAP’ note feels different after an MS diagnosis
April 18, 2024 News by Marisa Wexler, MS AAN 2024: Sustained myelin, nerve cell gains with long-term CNM-Au8
April 18, 2024 News by Lindsey Shapiro, PhD AAN 2024: Ocrevus benefits Black, Hispanic patients same as whites