News Compounds Targeting Inflammatory C-reactive Protein Under Study in Australia Compounds Targeting Inflammatory C-reactive Protein Under Study in Australia by Teresa Carvalho, MS | October 12, 2020 Share this article: Share article via email Copy article link A search is on for anĀ anti-inflammatory treatment targeting theĀ C-reactive proteinĀ ā CRP, a biomarker of inflammation produced by the liver ā of possible use inĀ a wide variety of conditions, including immune-mediated diseases such as multiple sclerosis (MS). Researchers at the Baker Heart and Diabetes Institute and the University of Melbourne, both in Australia, are working to find compounds that target CRP and may ease the inflammatory reaction its overproduction can provoke. āAn overshooting of the bodyās inflammatory response causes some of Australiaās most common and debilitating health conditions, including atherosclerosis ā the inflammation of arteries that can lead to heart attack and stroke ā sepsis, multiple sclerosis, arthritis, and viral infections such as COVID-19,ā Karlheinz Peter, MD, PhD, a cardiologist and deputy director at the Baker Institute, said in an instituteĀ press release. The research team has been studying the 3D structureĀ of CRP using techniques such as X-ray crystallographyĀ to better understand the protein’s structure and inflammatory function. This insight is expected to aid in finding and developing treatment candidates using a computer simulation program. Through a virtual library, scientists will search thousands of compounds already available for human use.Ā Each compound identified will be bound to the CRP structure via the computer program, with the most promising ones then being tested as treatment candidates. āUltimately we want to find which of these drug compounds will fit most tightly into the C-reactive proteinās pockets [regions in its structure] and by doing so inhibit inflammation,ā said Michael Parker, PhD, a structural biologist and director of Bio21 Institute at University of Melbourne. āWe already have some pilot data to narrow down the families of drug-like compounds that may work best. But they need optimization to find the specific drug that will block the C-reactive protein most effectively, so patients only need to take the smallest dose,ā Parker added. Previous studies on rats given a limb transplant showed that some identified compounds minimized the effects of inflammation, extending the animals’ life. According to the team, anti-inflammatory compounds targeting CRP could potentiallyĀ āalso reduce the amount of muscle lost in a heart attack, address the inflammation of joints that causes arthritis, and potentially reduce the progression of multiple sclerosis and other diseases where the immune system is overacting and fighting against the body,ā Parker said. Viral infections such as COVID-19 might also benefit from this work, the researchers said. āWhen you have any sort of virus, the liver produces lots of this C-reactive protein, sometimes leading to a 1000-fold increase in the body. And weāve seen with COVID-19 patients, when this protein marker is raised your chance of dying is sky high,ā Parker said. However, they stressed that any promising treatment coming from this work will take several more years to develop to the point of commercial use. āWhile the ultimate aim of our project is to have a drug on the market, drug development is costly and a lengthy process to ensure efficacy and safety in human patients,ā Parker said. This project is supported by AU$200,000 (almost $145,000) in seed funding from the Baker Department of Cardiometabolic Health at the universityās medical school. āWe expect that by continuing this significant collaboration, and by elevating that work through the new Baker Department of Cardiometabolic Health at the Melbourne Medical School, we will attract the further funding we need to get a highly promising drug to market,ā Parker added. Print This Page About the Author Teresa Carvalho, MS Teresa holds her Master of Science in cell and molecular biology from Coimbra University, Portugal. She was a researcher and science communicator for several years at the Institute for Research and Innovation in Health in Oporto, Portugal. From 2013, she has held a fellowship working with Pulmonary Hypertension Europe as a patient advocate, social media/website manager, public relations officer, and translator. Her work has been focused on providing patients access to treatments, raising awareness for pulmonary hypertension, and promoting patient empowerment. Tags Australia, inflammation
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