Human placental extract eased clinical symptoms, inflammation, and weight and myelin loss in a mouse model of multiple sclerosis (MS), a study reported.
Its researchers proposed that placental extracts be investigated as a way of better managing MS symptoms in people.
The study, “Human placental extract attenuates neurological symptoms in the experimental autoimmune encephalomyelitis model of multiple sclerosis-a putative approach in MS disease?” was published in the journal Autoimmunity Highlights.
MS, an autoimmune disorder, is caused by the immune system attacks on the protective coating of nerve fibers known as the myelin sheath, disrupting electric signals.
Extracts of human placenta are used in various Asian countries to treat a variety of health conditions. The extract contains hundreds of compounds, including hormones, growth factors, immune signaling proteins, and amino acids (the building blocks of proteins).
Studies have suggested these extracts have a broad range of biological activities, such as modulating immune responses, promoting wound healing, and reducing inflammation.
A team led by researchers at the Iran University of Medical Sciences tested human placental extract in mice with induced MS symptoms (experimental autoimmune encephalomyelitis, or EAE mouse model), and investigated the effects of the extract on molecules associated with the autoimmune response in MS.
“We hypothesized that the immunomodulatory effects of human placental extract might be conducive to attenuating neurological symptoms in association with EAE model of MS,” the researchers wrote.
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