May 27, 2022 News by Lindsey Shapiro, PhD Fecal Transplants Show Safety, Potential to Enrich Gut in Small Trial Repeated fecal transplants from healthy donors were safe and well-tolerated in a small group of people with relapsing-remitting multiple sclerosis (RRMS), a study reported. Treatment also showed a potential to ease intestinal permeability in MS and enrich the presence of protective microbes in the gut. Given that the trial…
October 13, 2020 News by Steve Bryson, PhD Human Placental Extract Effectively Treats MS Symptoms in Mouse Study Human placental extract eased clinical symptoms, inflammation, and weight and myelin loss in a mouse model of multiple sclerosis (MS), a study reported.Ā Its researchers proposed that placental extracts be investigated as a way of better managing MS symptoms in people.Ā …
January 3, 2019 Columns by Tamara Sellman Need to Know: Natural Strategies to Fight MS Inflammation Editor’s note: “Need to Know” is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum. This week’s question was inspired by the forum topicĀ “Do you know any natural remedies that help fight inflammation?“, from May…
November 5, 2018 News by Stacy Grieve, PhD Salt-rich Diet Appears to Trigger Inflammation and Promote Autoimmune Disease by Impact on T-cells, Study Reports Researchers at Yale uncovered a way that high-salt diets may trigger inflammation and possibly contribute to the development of autoimmune diseases such as multiple sclerosis (MS). Their study, “Activated Ī²-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity,” was recently published in the journalĀ Nature…
May 8, 2018 News by Patricia Inacio, PhD New Class of Anti-inflammatory Compounds May Help Halt Inflammation in MS, Study Suggests A new class of indoline derivativesĀ shows potent antioxidant and anti-inflammatory activitiesĀ capable of decreasing inflammation in the brain, new research shows. This finding highlights the potential of the new compounds in chronic inflammatory diseases, such as multiple sclerosis (MS). The study āSynthesis and Biological Evaluation of Derivatives of Indoline as…
January 10, 2018 News by Jose Marques Lopes, PhD Stem Cell Combo Therapy Shows Efficacy in MS Mouse Model, Korean Study Shows A combination therapy of low-dose methylprednisolone and interferon (IFN)-beta-secreting stem cells is effective in a mouse model of multiple sclerosis (MS), a new Korean study suggests. The research, āEffective combination of methylprednisolone and interferon Ī²-secreting mesenchymal stem cells in a model of multiple sclerosis,ā appeared in the…
October 31, 2017 News by Patricia Silva, PhD #MSParis2017 – Scant Difference Seen in Inflammatory Response to Ocrevus or Rituxan in Small Study Both Ocrevus (ocrelizumab) and Rituxan (rituximab) trigger a similar release of inflammatory mediators after a first infusion, with little difference seen in infusion reactions among a small group ofĀ multiple sclerosis (MS) patients treated with either therapy, said researchers from the Rocky Mountain MS Center at the University of…
May 23, 2017 News by Patricia Silva, PhD Brain IFN-gamma Drives MS Disease Processes, Russian Immune Factor Analysis Finds MS brain inflammation is a result of interactions between processes in the brain and the rest of the body, with interferon-gamma (IFN-gamma) being a key player, according to a detailed analysis of cytokines in the spinal fluid and serum of MS patients. Russia’sĀ Kazan Federal UniversityĀ found that IFN-gamma activates other…
April 20, 2017 Columns by Tamara Sellman The MS Alphabet: Cytokines, CSF, Corticosteroids and More ‘C’ Words (Editor’s note: Tamara Sellman continues her occasional series on the MS alphabet with this third of three parts on terms starting with the letter “C.”) When it comes to multiple sclerosis, mastering an understanding of the disease means you need to mind your Ps and Qs, dot your…
February 24, 2017 News by Patricia Inacio, PhD #ACTRIMS2017 – High Salt Diet Seen as Potential Risk Factor for MS in New Study New evidence strengthens the link betweenĀ a diet high in salt and multiple sclerosis (MS) development, researchers show. The study,Ā āSodium Chloride Intake and MS,ā was presented on Feb. 24 at the ACTRIMS) 2017 ForumĀ being held in Orlando, Florida, by Dr. David Hafler with theĀ Yale School of Medicine. The…
February 7, 2017 News by Patricia Inacio, PhD Natural Variations in Interleukin-16 Gene Linked to MS Risk in Small Study Small natural variations within the DNA sequence of the gene for interleukin-16 (IL-16) wereĀ linked toĀ anĀ increased susceptibility to multiple sclerosis (MS) in a small group of Iranian patients. The study, āThe Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis,ā was published in…
February 6, 2017 News by Patricia Inacio, PhD Researchers Identify Gene Regions with High Levels of Proteins Linked to MS A genome-wide study has identified DNA regions associated with higher levels of circulating cytokines, small proteins that pay aĀ role in inflammatory diseases such as multiple sclerosis (MS). Alterations in the levels and interplay of cytokines and growth factors play a key role in several inflammatory diseases, including MS.Ā Cytokines help regulate…
January 10, 2017 News by Patricia Silva, PhD Researchers Identify 2 Cytokines Responsible for Chronic Flares in Autoimmune Diseases Researchers have identified two factors that allow Th17 cells āĀ Ā which drive multiple sclerosis (MS) and other autoimmune conditions āĀ to form memory cells in the body and cause repeated symptom flare-ups. Knowing the identity of the molecules, which are immune mediators called cytokines, will make it possible for scientists to search…
November 15, 2016 News by Patricia Inacio, PhD Glial Cells Found to Play a Role in Pain Sensation in MS, Other Disorders Researchers have discovered that glial cells can also participate in pain sensation and enhance it in several disorders, including multiple sclerosis (MS). The study, āGliogenic LTP spreads widely in nociceptive pathways,ā was published in the journal Science. Our sensation of pain is processed in the brain…
February 17, 2016 News by admin MS Patients’ Likely Response to Interferon-Ī² May Be Evident in a Blood Biomarker A new study underscoresĀ the variability of immune responses in different people with multiple sclerosis (MS) and suggests this heterogenityĀ affects responsesĀ to the commonly prescribed MS medication interferon-Ī², but blood biomarkers may exist that can help to determine those most likely to benefit from such treatment. The study,Ā “Cytokine profiles…
February 5, 2016 News by Margarida Azevedo, MSc MS-related Inflammation May Be Reduced With Natural Protein, Study Shows In a new study using several mouse models of human immune-mediated inflammatory diseases, including multiple sclerosis (MS), researchers found that increased levels of an endogenous protein called tristetraprolin (TTP) resulted in protection against pro-inflammatory diseases. The results suggested that this natural protein might constitute a valuable therapeutic strategy to reduce…
February 4, 2016 News by Patricia Silva, PhD RRMS Drug Works by Shifting Anti-Inflammatory Immune Profile, Study Shows Researchers have found that changes in the compositionĀ of immune molecules ā specifically, a shift to more anti-inflammatory cytokines and regulatory T-cells (Tregs) ā likely account for the efficiencyĀ of alemtuzumab (Lemtrada) as a treatment for relapsing-remitting multiple sclerosis (RRMS). The study, titledĀ “Alemtuzumab long-term immunologic effect: Treg suppressor function…