July 22, 2019 News by Jose Marques Lopes, PhD Microbes in Gut Protect Nervous System After Viral Infections, Study Suggests Gut microbes prime immune cells called microglia to protect the brain and nervous system from neurological damage due to viral infections, according to new research in mice. The findings suggest that maintaining a healthy and diverse microbiota ā the population of bacteria, fungi, and viruses within the body, especially the…
March 22, 2018 News by Patricia Silva, PhD Symbiotix Obtains Access to Harvard Material That Could Help It Develop MS Therapies Symbiotix BiotherapiesĀ has gained access to Harvard UniversityĀ material thatĀ could help it develop treatments for autoimmune and inflammatory diseases like multiple sclerosisĀ and inflammatory bowel diseases. It obtained access to the intellectual property, much of which deals with gut bacteria, under a licensing agreement with Harvard. Intellectual property typically includes…
November 22, 2017 News by Alice MelĆ£o, MSc Gut Bacteria Contribute to MS Onset and Development, Rutgers Mouse Study Shows Exposure to certain gut bacteria at a young age may cause multiple sclerosis (MS) and fuel its progression, a new mouse study shows. The study, āGut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood,ā appeared in the journal Proceedings of the National…
October 16, 2017 News by Ana Belo van Wijk, PhD One More Small Piece of the Puzzle on the Role of Gut Micro-organisms in MS Researchers found a significant increase in some types of gut bacteria and lower levels of an anti-inflammatory factor in untreated multiple sclerosis twins. The study offered working evidence that components of gut microbiota contribute to autoimmune diseases like MS. Researchers published their articleĀ in the journal Proceedings of the National Academy of Sciences.It was titledĀ "Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice." Our gut contains millions of good bacteria, fungi, bacteria-like archaea, and viruses that we can't live without. Although there are 300 to 1,000 species of bacteria in our gut, most of our intestines is populated with 30 or 40 species. RecentĀ increases in knowledge and technical advancements have made it possible for scientists to measure the equilibrium between different species in the gut, and analyze their influence on our health. One discovery was a link between the balance of bacteria in the intestines and autoimmune diseases like MS. A team of researchers decided to see if differences in gut microbiota play a role in MS progression and perhaps its onset. They analyzedĀ the feces of 34 identical twins, one of each who had MS and one of each who didn't. They used twins to try to reduce genetic and environmental differences' influence on the onset of the disease. All of those with MS were Caucasian andĀ had grown up with their healthy twin to adulthood. Researchers analyzed the type and abundance of microorganisms in the feces of both the MS-affected and healthy twins. They found no differences in species or amount of bacteria between siblings. What they did find was a significant increase in some types of bacteria, such as Akkermansia, in untreated twins with MS. The team transplanted fecal samples from MS-affected and healthy twins into a mice model of MS called experimental autoimmune encephalomyelitis. These animals have an inflammatory myelin-destroying disease of the central nervous system that is comparable to human MS. Myelin is a protective coating around neurons whose loss is associated with MS. MS twin-derived gut microbiota caused a significantly higher amount of mice to develop a relapsingāremitting autoimmunity similar to MS than healthy twin-derived microbiota. When researchers measured the microbial profiles of the mice's feces, they found significant differences in amounts of bacteria.Ā The most important difference was inĀ Sutterella, an organism that helpsĀ protect against inflammation. SutturellaĀ levels were significantly reduced in the feces of mice transplanted with MS twin-derived microbiota compared with feces from healthy twins. The team alsoĀ measured the mice's immune cells and the proteins they release. They discovered that immune cells in mice with MS-twin feces transplants produced less of the anti-inflammatory factor IL-10 than immune cells from mice colonized with healthy-twin samples. IL-10, or interleukin 10, is an important immune protein. When researchers transplanted the feces of healthy twins into the mice, then gave them an antibody that blocks the function of IL-10, they also became sick. This indicated that IL-10 may temper autoimmunity in the central nervous system. The team then measured the twins' immune blood components. They found that the healthy twin had higher quantities of IL-10 than the MS-affected one. This isĀ a complex issue in which very subtle differences of type and amount of bacteria in the gut can have considerable consequences, they added. Ā
December 8, 2016 News by Alice MelĆ£o, MSc Imbalances in Brain Microbiota May Be Behind Demyelination in MS, Study Says Alterations in microorganisms in the brains of multiple sclerosis (MS) patients could contribute to underlying disease mechanisms, including demyelination, according to researchers. The study, āBrain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis,ā was published in the journalĀ Scientific Reports. It is widely recognized that the…
September 15, 2016 News by Patricia Silva, PhD #ECTRIMS2016 – Immune Cells Linked to Autoimmunity Found in MS Patients’ Gut Immune cells, believed to drive autoimmunity, are selectively increased in the gut of patients with multiple sclerosis (MS), along with lower numbers of cells controlling inflammation, suggesting that immune processes in the gut impact MS disease mechanisms. The study, āThe role of gut immunity in multiple sclerosis patients,ā…
May 24, 2016 News by InĆŖs Martins, PhD New Research Center at UC San Diego to Focus on Microbiome and Immunology TheĀ University of California (UC) San Diego School of Medicine and Chiba University School of Medicine, Japan, are working togetherĀ to establishĀ a newĀ center forĀ immunology research, with a particular focusĀ on the microbiome and mucosal immune responses that are knownĀ to play a crucial role in a variety of diseases, including multiple sclerosis (MS). āThis…
October 13, 2015 News by Patricia Silva, PhD Importance of Microbiota in MS Development Explored in ECTRIMS 2015 Presentation Three parallel sessions concerning multiple sclerosis (MS) prevention, clinical phenotypes and magnetic resonance imaging (MRI) were featured at the 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), recently held in Barcelona, Spain (October 7 ā 10, 2015). The first parallel session was entitled āWill…