research

Increased activation of microglia, the resident immune cells in the brain that contribute to chronic inflammation in multiple sclerosis (MS), is significantly associated with higher levels of neurofilament light chain (NfL) protein, indicating more nerve damage, a study found. Researchers particularly identified strong links between…

The rate of multiple sclerosis (MS) diagnoses have remained relatively constant for almost 20 years in the U.K., according to a population-based study involving more than 22 million people. Most MS diagnoses occurred during middle age, with women being more likely than men to receive a…

Modified nanocapsules containing retinoic acid can suppress inflammation and prompt the growth of cells that produce nerve fibers’ myelin coating, which is lost in multiple sclerosis (MS), a cell-based study shows. The results demonstrated how lipid (fat) nanocapsules that contain medicines can access the brain and treat the two…

Interleukin-3 (IL-3), an inflammatory signaling protein, seems to coordinate the recruitment of immune cells from the blood into the brain, leading to worsening inflammation and symptoms related to multiple sclerosis (MS), a study revealed. Targeting IL-3-mediated communication may be an effective therapeutic strategy for MS and other brain disorders,…

A protein called Mfsd2a, which transports molecules that contain omega-3 fatty acids, is essential for regulating cells that make the fatty coating on nerve fibers, or myelin sheath, that’s damaged in multiple sclerosis (MS), a study indicates. In mice lacking Mfsd2a, the cells that make myelin, or oligodendrocytes, fail…

Neurologist Robert Lisak, MD, has been named a 2023 Giant of Multiple Sclerosis for his work in understanding the mechanisms of multiple sclerosis (MS) and improving care for people with the condition. Lisak, MD, a professor of neurology and former chair of the Wayne State University Department of Neurology,…

Attaching a kind of molecule backpack to myeloid cells — a type of immune cells involved in the inflammatory attack that drives multiple sclerosis (MS) — may help to halt inflammation and damage in the brain in MS by modulating immune cell activity, a study…

A four-month home-based aerobic walking program was feasible and may help improve cognitive function for multiple sclerosis (MS) patients, according to data from a recent pilot study funded by the Kessler Foundation. Findings from this small study support the design of a randomized, controlled clinical trial to evaluate…

The Multiple Sclerosis Association of America (MSAA) is collaborating with Novartis and the Chronic Health Improvement Research Program (CHIRP) at Dartmouth Health to establish a multicenter learning health network for providers to drive better outcomes for multiple sclerosis (MS) patients. Called the Multiple Sclerosis Implementation Network…

A newly developed laboratory model using tadpoles can help determine the remyelinating potential of new multiple sclerosis (MS) therapies via specific changes in behavior and vision tests, a new study suggests. The model may help accelerate the discovery of potential MS remyelinating therapies, and reduce the use of resources…

Blood levels of the nerve damage marker NfL seem to spike to very high levels around times of disease activity in children with multiple sclerosis (MS), a new study reports. The findings support using NfL as a biomarker of disease activity, in the form of relapses or lesions, in…

Tysabri (natalizumab) is generally safe and effectively lowers disease activity in people with multiple sclerosis (MS), according to a real-world study of patients over a 13-year period in Denmark. “Most patients treated with [Tysabri] are clinically stable with few adverse events,” researchers wrote. In more recent years, doctors…

Jonathan Allenger, diagnosed with multiple sclerosis (MS) a decade ago, is planning to bike more than 6,000 kilometers (3,700 miles) across Canada to raise awareness and CA$1 million for MS research and patient support services. Proceeds from the journey — set to begin on May 7 and conclude by…

Clusters of immunoglobulin G (IgG) antibodies in the blood of multiple sclerosis (MS) patients appear to contribute to the nerve cell death that marks the neurodegenerative disease, according to a recent study. IgG antibodies harvested from the blood of MS patients drove nerve cell death in cell cultures, whereas antibodies…

Rehabilitation therapy that utilizes virtual reality can help to improve balance and reduce the fear of falling for people with multiple sclerosis (MS), a new analysis shows. “Our findings provide support to the use of [virtual reality-based therapy] to recover balance in neurological diseases such as MS,” researchers wrote.

Use of the cell therapy MSC-NP failed to show a significant effect on overall disability scores among people with progressive forms of multiple sclerosis (MS), according to data from a Phase 2 clinical trial. Results, however, indicated that MSC-NP improved walking ability for people with more advanced disease —…

Damage to the myelin sheath, a hallmark feature of multiple sclerosis (MS), leads to increased levels of fatty molecules called VLCFAs, which are converted by brain cells into an inflammation-driving signaling molecule called S1P, a study suggests. The discovery of this novel molecular pathway may open up new avenues…

Tokachi, a region in northern Japan, has seen a steady increase in the prevalence or proportion of people in the population living with multiple sclerosis (MS) over the past two decades, a recent study found. Data show the disease has also become more common in women in northern…

People with secondary progressive multiple sclerosis (SPMS) seem to experience slower worsening of their disabilities than those with the primary progressive form of the disease (PPMS), a new study reports. However, SPMS patients tend to be older and have more advanced disability when they enter the progressive stage…

Multiple sclerosis (MS) patients with greater psychological resilience — a better ability to cope with and recover quickly from problems and difficulties — tend to have higher levels of social and occupational functioning, a new study found. Resilience was linked to a number of functions, including relationships, communication, social…

A novel formulation of ibudilast, delivered into the nose, was able to reduce inflammation and prevent nerve damage in a mouse model of multiple sclerosis (MS), a study found. The nasal formulation also improved regeneration of myelin, the protective sheath around nerve fibers that is progressively lost…

A three-month yoga program was significantly better than physical therapy at improving quality of life in people with multiple sclerosis (MS), a Russian study reports. Significant effects were observed in patients’ physical and social functioning, life activity, and mental health, researchers found. “Regular yoga classes under the guidance of…

Abnormal perceptions of discomfort and fatigue likely play a role in causing increased heat and cold sensitivity to extreme temperatures among people with multiple sclerosis (MS), a new study shows. However, the results suggest that MS does not generally affect how the body regulates its own temperature. “Our findings…

The U.S. Food and Drug Administration (FDA) has placed a partial clinical hold on ongoing trials of evobrutinib, Merck KGaA’s experimental BTK inhibitor for relapsing forms of multiple sclerosis (MS). The decision was based on two cases of patients in Phase 3 clinical trials of evobrutinib who were…

The benefits of Mavenclad (cladribine) were sustained for up to 15 years after its last treatment course in people with relapsing multiple sclerosis (MS), according to real-world data from the CLASSIC-MS study. More than half of those who received the oral therapy in the clinical trials that supported…

One year of treatment with Lemtrada (alemtuzumab) significantly improved cognitive abilities, particularly with processing speed, and eased depression in people with relapsing forms of multiple sclerosis (MS), a small real-world study reported. Most of the 39 patients (92%) evaluated after that treatment year showed either stable or improved…

OCH, a molecule designed to have beneficial effects on immune regulation in multiple sclerosis (MS), led to increases in regulatory immune cell subsets and immunomodulatory gene activity in healthy volunteers and MS patients. That’s according to data from a first-in-human study of the compound, which also found the immune…

EBViously announced that it has developed a candidate vaccine against the Epstein-Barr virus and plans to bring it into clinical trials starting in 2024. The company is a spinoff of Helmholtz Munich, part of a German government research network. It is led by scientists with expertise in EBV…

OCS-05, a neuroprotective treatment candidate being developed by Oculis for multiple sclerosis (MS) or other causes of optic nerve inflammation, demonstrated a favorable safety and pharmacological profile in healthy volunteers, according to Phase 1 trial data. A Phase 2 trial (NCT04762017), called ACUITY, is now evaluating OCS-05’s…

Early treatment with Mavenclad (cladribine) or monoclonal antibodies is more likely to control symptoms in people with highly active multiple sclerosis (MS), a study in Argentina suggests. Highly active disease usually is considered when frequent relapses occur and there is an increasing burden of brain magnetic resonance imaging…