Multiple sclerosis (MS) is a pain in my butt — and other places, too. It hasn’t always been that way. For many years post-diagnosis, I didn’t notice much pain. But of the 43 years I’ve lived with MS, it’s hurt for the past 15. Usually, it’s just…
symptoms
An antibody biomarker may help to distinguish people with a disease that resembles multiple sclerosis (MS), but may actually be its own clinical disorder, according to a new study. The biomarker was present in about 1% of MS patients and in 6% of those with a related demyelinating condition…
I like to look up. No, I’m not referring to my disposition, although I do consider it to be an improvement over what it once was. I’m actually pretty sunny, if you happen to think of “sunny” as burning, harsh, and damaging when you’re exposed to it. What I…
Estimates of the prevalence of sexual dysfunction with multiple sclerosis (MS), as well of its risk factors, differ depending on the specific cutoffs used to assess sexual health on a standardized test, a study highlights. Regardless of the cutoff given, however, findings suggest that patients with poorer cognition tend…
A significantly higher immune response against proteins found in cow milk is evident in people with multiple sclerosis (MS), likely because of similarities between milk proteins and proteins in the human central nervous system (CNS, the brain and spinal cord), a study reported. No such differences were seen between…
I was never a hypochondriac until multiple sclerosis (MS) whacked me. A catastrophic fall while playing tennis in 2007 resulted in a shoulder separation that took two operations to fix. The pain was so bad that, at the time, MS was just something else I had. To be accurate,…
Neurofilament light chain (NfL) protein levels can be used to assess neurodegeneration in children and adolescents with neurological disease, including multiple sclerosis (MS), even when they are not experiencing any symptoms, a study has found. The protein already had been established as a biomarker of disease activity and poor…
Following a ketogenic diet — one that’s low in carbohydrates and rich in fat — for six months significantly reduced measures of body fat and fatigue, eased disease symptoms, and improved exercise capacity, cognition, and arm and hand dexterity in people with relapsing-remitting multiple sclerosis (RRMS), a study showed.
In people with relapsing forms of multiple sclerosis (MS), relapses that occur in the first few years after the disease develops have a strong impact on rates of disability worsening — but after about 2.5 years, more relapses don’t consistently result in a greater worsening of disability, according to…
Pro-inflammatory immune cells that can target the brain may be activated in a specific region of the intestine by certain gut bacteria before migrating to the brain, according to a new study done in mice. Researchers say these findings provide a proof of concept for how some immune cells may…
Dawn Health, a Danish digital health company, has developed a smartphone app to support and empower people living with multiple sclerosis (MS) as they navigate their chronic disease care. Launched this week in Germany, the free Ekiva-MS app is designed to help patients better track their symptoms…
In multiple sclerosis (MS), inflammation leads to less energy production in nerve fibers by reducing the levels of enzymes in a key molecular pathway, called the TCA cycle, that cells use to generate energy, a new study shows. These findings imply that boosting activity of the TCA cycle might…
Primary progressive multiple sclerosis (PPMS) can greatly reduce quality of life for patients and affect their ability to work, according to real-world data collected from a German MS registry. These results “confirm the steadily deteriorating course of PPMS accompanied by increasingly limited quality of life,” researchers wrote. The study,…
As last week’s column ended, I’d just negotiated with my ambulance driver and paramedics to take me to any London hospital other than the one where I’d spent the Christmas months. They offered me St George’s Hospital, which I knew to be the major trauma center ’round these…
Experiencing disability in the early stages of multiple sclerosis (MS), even without relapses, increases the risk of progression to secondary progressive MS (SPMS), a more severe form of the disease, a large study finds. Starting a disease-modifying therapy early on in the disease may decrease the SPMS…
The presence of spinal cord lesions — alone or with brain lesions — on MRI scans was associated with a higher risk of clinical relapse for multiple sclerosis (MS) patients over those with just brain lesions, according to a recent study. Spinal and brain lesions together were also predictive…
Editor’s note: “MS News Notes” will return to its regular Monday morning schedule next week. Welcome to “MS News Notes,” a column where I comment on multiple sclerosis (MS) news stories that caught my eye last week. Here’s a look at what’s been happening: A 10-minute injection of…
Relapsing-remitting multiple sclerosis (RRMS) patients with elevated levels of chloride in their cerebrospinal fluid (CSF), the fluid that bathes the central nervous system, may be at a higher risk of relapse, according to a study from China. Researchers propose that CSF chloride levels equal to or higher than 123.2…
There was no column from me last week, and here follows the reason why: “In the wee small hours,” as Frank Sinatra so eloquently crooned, I, too, was abruptly awake. Only I hadn’t drunk my way there. Instead, my wee was indeed a real one, though painfully…
I’m drinking again, more than I have in years. It’s not the hard stuff, though; not even beer or wine. It’s just plain water. That may sound crazy for someone like me who has bladder problems due to multiple sclerosis (MS). For many of us with MS, we…
Inflammation in the membranes around the brain may trigger an inflammatory response that can spread into nearby brain tissue, a new study in a mouse model of multiple sclerosis (MS) shows. Researchers say these findings may help to advance scientists’ understanding of the mechanisms that underlie brain damage in…
I am not left-handed! No, I’m not channeling Westley or Inigo from “The Princess Bride,” just clarifying a common — and fair — assumption. While I now do nearly everything left-handed, including eating, drinking, and even typing this column, my right hand was dominant for most of…
Elevated blood levels of neurofilament light chain (NfL), a marker of nerve damage, are associated with long-term disability progression in people with multiple sclerosis (MS) — even among those without acute relapses or MRI disease activity — a study revealed. The results demonstrate the potential utility of NfL blood…
Adding optic nerve damage — reflected by a thinning of the nerve layer in the eye’s retina — to the existing diagnostic criteria for multiple sclerosis (MS) was found to enhance diagnostic accuracy among people who had a single, MS-like event, according to a new study. The study “demonstrated…
Welcome to “MS News Notes,” a Monday morning column where I comment on multiple sclerosis (MS) news stories that caught my eye last week. Here’s a look at what’s been happening: Testing a new MRI contrast agent One concern that some people with MS have when getting an MRI…
Women with multiple sclerosis (MS) are three times more likely to face problems with sexual intimacy than are their healthy counterparts, according to a recent meta-analysis. About 61% of women with MS were estimated to have some degree of sexual dysfunction, with the most common being low…
Nerve cells coated with myelin — the fatty substance that’s lost in multiple sclerosis (MS) — may be more vulnerable to degeneration in an inflammatory environment than cells lacking myelin, researchers working in MS patient tissues and mouse models report. The scientists believe the phenomenon arises when certain…
Gadoquatrane, a gadolinium-based contrast agent (GBCA) that may be safer than current agents for people undergoing MRI scans, has entered a Phase 3 clinical testing program. Quanti CNS (NCT05915702), one of the three global trials in Bayer‘s development program, will assess gadoquatrane against an…
Cigarette smoking significantly slows recovery time from a relapse for people with relapsing-remitting multiple sclerosis (RRMS), according to a pilot study in Iran. Similar links with relapse recovery were not seen for tobacco use with water pipes or exposure through second-hand smoke, also known as passive smoking. Findings add…
It’s only day one, but my eyesight has already improved. It may not be that of a hawk’s, but at least I can tell the difference between a lumbering pigeon and a bird of prey. The world seems brighter — and not just because of that vision thang, peeps. If…