treatment

A pair of experts are calling for genetic tests to be developed to identify people at higher risk of developing progressive multifocal leukoencephalopathy (PML), a serious brain infection that can occur as a side effect of certain multiple sclerosis (MS) treatments. “The availability of a simple, relatively inexpensive test…

Photo courtesy of Shane Nicolich Day 21 of 31 This is Shane Nicolich’s story: I was on my first multiple sclerosis (MS) treatment for six years but experienced bad side effects. That sucked, since I’m a dishwasher at a busy restaurant and am on my feet all day.

Disease relapses are no more likely in women with multiple sclerosis (MS) after fertility treatment than they were before such treatment, a study found. Researchers also observed that almost half of the women receiving fertility treatment were on disease-modifying MS therapies, which may have helped to keep a…

Most neurologists in the U.S. are aware of the recent approval of Briumvi (ublituximab-xiiy) for the treatment of relapsing forms of multiple sclerosis (MS) and about half anticipate testing the therapy in the next six months, according to an analysis by market research company Spherix Global Insights. The therapy, developed…

Choosing the best disease-modifying therapy (DMT) to treat your multiple sclerosis (MS) can be a tough decision.  When I was diagnosed with MS way back in 1980, it was easy. There were no DMTs to choose from. The first three — Avonex (interferon beta-1a), Betaseron…

Supplementation with phosphoenolpyruvate (PEP), a molecule produced during cellular energy generation, eased the signs and symptoms of multiple sclerosis (MS) in a mouse model of the disease, a study revealed. The metabolite inhibited a protein called JunB, which blocked the production of the pro-inflammatory molecule interleukin-17 (IL-17) and suppressed…

The Kanabo Group has established what it claims is the U.K.’s first online medical cannabis clinic to help people with multiple sclerosis and other conditions manage chronic pain. Called Treat It, the clinic is expected to help those whose conventional pharmaceutical medicines are ineffective or those…

Higher blood levels of Ocrevus (ocrelizumab) is associated with a significantly lower risk of confirmed disability progression during treatment in people with relapsing and progressive forms of multiple sclerosis (MS), according to an analysis of data from three Phase 3 clinical trials. Notably, the lower disability progression rates reported in…

Nassira and her husband, Dwayne Howse. (Photo courtesy of Nassira Powell) Day 14 of 31 This is Nassira Powell’s story: I was diagnosed with multiple sclerosis (MS) in 2018. Like many, I knew nothing about the disease and was left with many questions. My first appointment with a…

Transcutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) — both interventions apply electrical stimulation through electrodes placed on the skin — can help to ease pain in people with multiple sclerosis (MS), according to results from a small clinical trial. Results suggested that, while both treatments can reduce…

Welcome to “MS News Notes,” a Monday morning column in which I comment on multiple sclerosis (MS) news stories that caught my eye last week. Here’s a look at what’s been happening: A different type of stem cell transplant When stem cell transplant is mentioned to treat someone…

Aiming to promote equitable access to multiple sclerosis (MS) treatments worldwide, an international MS alliance is asking that three disease-modifying therapies (DMTs) be added to the World Health Organization’s (WHO) list of essential medicines. Inclusion on the WHO list is considered an important if “initial” step in assuring that helpful treatments…

MSC-NP, a form of stem cell therapy that’s currently in early clinical trials for multiple sclerosis (MS), can reduce the inflammatory activity of brain immune cells called microglia, according to a new study. The therapy is known to reduce disease severity and improve myelin regeneration in animal models of…

Photo courtesy of Cassidy V. Chapman Day 10 of 31 This is Cassidy V. Chapman’s story: I was diagnosed with relapsing-remitting multiple sclerosis in January 2004 at the age of 22, the day before my 23rd birthday. It happened during my first year of law school. Still,…

Neurologists in the U.S. are generally favoring more aggressive early treatment for multiple sclerosis (MS), according to an analysis by market research company Spherix Global Insights. With over a dozen therapies available in the U.S. to treat relapsing forms of MS, patients and providers have options to…

GA Depot, an experimental long-acting version of glatiramer acetate, significantly reduced relapse rates and prevented the development of new lesions among people with relapsing forms of multiple sclerosis, according to new data from a Phase 3 clinical trial. Disability levels also were significantly reduced with the treatment, given…

New data from a Phase 2 clinical trial testing vidofludimus calcium, Immunic Therapeutics’ novel oral treatment candidate for relapsing-remitting multiple sclerosis (RRMS), show promising safety and efficacy, according to the company’s chief medical officer. The therapy was found to safely reduce brain lesions and prevent disability progression in…

Even the cold and rainy Southern California weather did little to dampen the excitement of the more than 1,800 attendees converging on the Marriott Marquis San Diego Marina. People filtered in, eager for the meeting to begin. Excitement reached a fever pitch Thursday morning as the curriculum came to life.

Briumvi (ublituximab-xiiy) recently became the third anti-CD20 monoclonal antibody to be approved by the U.S. Food and Drug Administration (FDA) as a treatment for relapsing forms of multiple sclerosis (MS). TG Therapeutics, the therapy’s developer, is now aiming to make Briumvi the most accessible therapy in its…

Want to reduce your multiple sclerosis (MS) fatigue? Maybe we should talk about it. I’m talking about a fatigue treatment called cognitive behavioral therapy (CBT), which usually involves changing a person’s thinking and behavior. By talking with a therapist, sometimes on the phone, a patient develops an…

More than half of the people with relapsing forms of multiple sclerosis (MS) who received Briumvi (ublituximab) in the ULTIMATE clinical trials had no signs of disease activity over the first six months of the trial — and over 80% of participants had no disease activity for the…

Treatment with the experimental oral suspension therapy CNM-Au8 led to improvements in measures of vision, cognitive and motor function, and brain health for people with multiple sclerosis (MS), according to data from the proof-of-concept VISIONARY-MS trial. Bolstered by these positive results, Clene Nanomedicine is planning to launch a…

Limiting calorie intake over two days of each week for three months led to beneficial immune and metabolic changes, as well as improvements in cognitive function, among people with relapsing-remitting multiple sclerosis (RRMS), a study found. A restrictive diet also promoted a better body composition, namely a reduction in…

A history of infection with Epstein-Barr virus (EBV) has been shown to be a strong risk factor for developing multiple sclerosis (MS) — but is targeting the virus a viable strategy for MS prevention or treatment? This question was the subject of a debate, “How To…

Cognitive behavioral therapy (CBT), a form of talk therapy, and medication given separately or in combination can ease fatigue significantly for people with multiple sclerosis (MS), according to new data from a clinical trial. The effect on fatigue was comparable for talk therapy, medication, or the combination in validated…

Evobrutinib, an experimental BTK inhibitor being developed for people with relapsing forms of multiple sclerosis (MS), continues to be well tolerated and is showing low relapse rates after four years of treatment. That’s according to new data spanning a Phase 2 trial (NCT02975349) that tested evobrutinib against…

A Phase 2 clinical trial evaluating whether a low dose of ketamine can ease fatigue in people with multiple sclerosis (MS) is enrolling patients at Johns Hopkins University in Baltimore. The study, called INKLING-MS (NCT05378100), is recruiting up to 110 patients, ages 18-65, who have been complaining of fatigue as…

Lawrence Steinman, MD, a professor of neurology who is leading the development of Pasithea Therapeutics‘ PAS002 for the treatment of multiple sclerosis (MS) has received the 2023 Pioneer in Medicine Award. The prize is given by the Society for Brain Mapping & Therapeutics (SBMT) and the World Brain…

Helius Medical Technologies will showcase its noninvasive Portable Neuromodulation Stimulator (PoNS) device and provide training to physical therapists who are interested in using the device for the treatment of multiple sclerosis (MS). The company will explain the benefits of PoNS…

Treatment with docosahexaenoyl ethanolamide (DHEA), an omega-3 fatty acid found in fish oil, reduced inflammation and disease severity in a mouse model of multiple sclerosis (MS). These findings suggest that “an increase of omega-3 consumption may be beneficial to patients diagnosed with MS,” researchers said. “We believe our findings…