Vatelizumab (GBR 500) is a humanized monoclonal antibody antagonist of the VLA-2 (alpha2-beta1) integrin (a collagen-binding molecule expressed on activated lymphocytes).1 Vatelizumab was licensed to Sanofi for two Phase 2 clinical trials on multiple sclerosis (NCT02222948) (NCT02306811) but Sanofi decided not to pursue further vatelizumab as a potential therapy for relapsing-remitting multiple sclerosis (RRMS), following the results of a pre-planned interim analysis that revealed that the primary efficacy endpoint was not met. This decision was not due to safety concerns.
Glenmark decided to continue relicensing of GBR 500 after it is returned from Sanofi.
Vatelizumab’s mechanism of action is not known, but it is believed that it blocks the VLA-2 integrin on activated immune cells, leading to an interference with collagen-binding in inflammation sites, preventing them from entering the brain and spinal cord and thus stopping them from attacking and damaging myelin3, reducing the inflammatory cascade in multiple sclerosis process.
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