An extension of a Phase 3 clinical trial has shown that early treatment with Rebif (interferon beta-1a) in patients with initial manifestations of multiple sclerosis (MS) can prolong the time to a clinically definite multiple sclerosis (CDMS) diagnosis over five years.
The study, “Subcutaneous interferon β-1a in the treatment of clinically isolated syndromes: 3-year and 5-year results of the phase III dosing frequency-blind multicentre REFLEXION study,” reports the findings of the REFLEXION clinical trial (NCT00813709) conducted in 24 countries. The article was published in the Journal of Neurology, Neurosurgery, and Psychiatry.
MS often presents with a first clinical demyelinating event (FCDE) that affects the optic nerve, brain stem, or spinal cord. Studies have shown that 38% to 45% of untreated patients will progress to CDMS within two years.
CDMS can be diagnosed based on a new attack or a sustained increase in disability. Alternatively, the McDonald approach uses magnetic resonance imaging (MRI), which takes into account the presence and extent of identified lesions to diagnose and monitor CDMS.
REFLEXION was an extension study of the multi-center double-blind REFLEX (NCT00404352) Phase 3 study. Results from REFLEX showed that early treatment with Rebif 44 micrograms, initiated after FCDE and administered subcutaneously (beneath the skin) three times a week or once weekly over 24 months delayed conversion to CDMS compared with placebo.
The REFLEXION study evaluated the benefits of more frequent and early dosing vs. delayed treatment on the course of the disease over 60 months. Patients who received Rebif 44 micrograms three times or once weekly in the REFLEX trial and who had not progressed to CDMS continued with their original treatment regimen. Patients who originally received a placebo who had not converted to CDMS were switched to Rebif three times a week and formed the delayed treatment group.
In total, 402 patients continued in the REFLEXION trial.
After 36 months, patients with delayed treatment had a 41.3% cumulative probability of progressing to CDMS compared to approximately 27% for patients who received either dose of Rebif. In all groups the number of patients who converted to CDMS had increased at month 60. However, patients receiving early treatment were still less likely to progress than patients with a delayed treatment. There was no observed difference between the different dose frequencies (three times weekly vs. once a week).
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