Cannabidiol Compound, EHP-101, Seen to Prevent Nerve Cell Damage in MS Mouse Model

Cannabidiol Compound, EHP-101, Seen to Prevent Nerve Cell Damage in MS Mouse Model

An investigational cannabidiol-derived compound called EHP-101 may help to boost remyelination, prevent nerve cell damage and lower the reactivity of microglia cells — immune cells of the brain and spinal cord — a  study in mouse models of multiple sclerosis (MS) reports.

EHP-101, being developed by Emerald Health Pharmaceuticals, was also reported to be of benefit in a model of scleroderma.

Emerald plans to start a Phase 1 clinical trial of the oral, cannabidiol (CDB)-derived potential treatment later this year.

These findings were presented at the recent 28th Annual Symposium of the International Cannabinoid Research Society (ICRS), held in Leiden, The Netherlands.

CBD is one of the more than 100 pharmacologically active compounds (cannabinoids) found in the cannabis plant.

Researchers investigated the effects of EHP-101 (previously known as VCE-004.8) in two mouse models of MS, the experimental autoimmune encephalomyelitis (EAE) and the Theiler’s virus-induced encephalopathy (TMEV) models.

In the TMEV model, treatment with EHP-101 — which is based on a new, synthetic cannabidiol — prevented such MS hallmark alterations as demyelination (the loss of the protective layer of nerve fibers, or axons, called myelin) and nerve cell damage. Its use also suggested an increase in remyelination.

In the widely used EAE mouse model, EHP-101 demonstrated marked dose-dependent benefits. In the spinal cord, it reduced the expression of diverse genes involved in MS, including inflammatory molecules and proteins implicated in cellular adhesion to other cells or the extracellular matrix — which provides structural and biochemical support to cells.

Join the discussion about medicinal cannabis and CBD in our MS News Today FORUMS!

Data also revealed lesser microgliosis, which is a nonspecific and intense reaction by microglia — a cell of the central nervous system — in response to damage. These effects were mediated through activation of the hypoxia inducible factor (HIF)-dependent neuroprotective pathway, known to play a role in immunological responses and the formation of blood vessels.

The MS-related study, “Effect of Oral VCE-004.8, A Cannabidiol Quinol Derivative On Experimental Autoimmune Encephalomyelitis,” was presented by Carmen Navarrete, PhD.

Results of these preclinical EHP-101 studies in MS mice were also published in the Journal of Neuroinflammation in March.

“The development of novel treatments aimed at axonal repair and remyelination remains a key objective in the treatment of MS,” Jim DeMesa, MD, CEO at Emerald, said in a press release. “Our scientists have demonstrated EHP-101’s potential to address this significant unmet medical need and possibly transform the treatment of MS, in addition to its potential as a disease-modifying treatment for scleroderma.”

Emerald’s study in scleroderma, Oral EHP-101 Alleviates Skin and Lung Fibrosis in Bleomycin Model of Scleroderma,“presented by Adela Garcia, expanded on previous research in showing that EHP-101 worked to prevent skin and lung fibrosis (scarring) in mice, with efficacy comparable to another synthetic cannabinoid derivative called ajulemic acid.

However, unlike ajulemic acid, EHP-101 was seen by researchers to lessened vascular damage. EHP-101 was also reported to decrease skin thickness and inhibit the infiltration of inflammatory cells, and further reduced the expression of genes and biomarkers associated with inflammation and fibrosis.

The scientists believe these results suggest that EHP-101 is a potential new way to manage and treat scleroderma and other fibrotic diseases.

According to Emerald,  EHP-101’s potential benefits are superior to other CBD products in development because of its greater  agonist activity via the cannabinoid receptors CB2 and PPAR-gamma. Prior research showed that these receptors help prevent inflammation and demyelination in the central nervous system, and the proliferation of fibers in the periphery.

16 comments

    • Libbie Frank says:

      I would suggest clicking on the link for Emerald Health Pharmaceuticals. You can contact them about the trial. I’m in California and can get CBD legally now without a doctor’s endorsement. I find it does help with some of my MS symptoms.

  1. Rosanne Costain says:

    If this study would include the greater Vancouver B.C. area I would love to try.
    The university of British Columbia says I am too old for their studies as I am 64.
    I have had obvious symptoms since 1987 and was diagnosed in 1994.
    I had angioplastyabout 3 yrs ago.
    It halped,but, now some symptoms are starting to re-surface.

  2. Iwould like to start using this EHP-101immediately if possible, include me as a special human trial. I have Secondary MS already due to accelerated brain atropy and since one year ago got contaminated with HIV, completely uncommon among MS patient aggravating my inflammation brain process. I was virus supressed for over one year with the Infecto Disease doctor refused to give to me ART. I started one month ago by my option one with new integrase Biktarvy that works well in the brain. I am searching for more help in my double autoimmune conditions.

  3. Mary Bozych says:

    Would be honored and most grateful to partake in any clinical
    trials. Diagnosed in 1996 with RRMS. Have now advanced to SPMS.
    Using medical cannabis now and it’s remarkable! CBD has become my new best friend!

Leave a Comment

Your email address will not be published. Required fields are marked *