The levels of three small, regulatory RNA molecules — long non-coding RNAs — are deregulated in blood samples of patients with relapsing-remitting multiple sclerosis (RRMS), a study reports.
The long non-coding RNAs are involved in the regulation of the natural immune response and DNA-damage response, supporting the theory that these pathways may be potential contributors for MS.
The study “Dysregulation of long non-coding RNA profile in peripheral blood of multiple sclerosis patients” was published in the journal Multiple Sclerosis and Related Disorders.
Long non-coding RNAs regulate the activity (expression) of genes involved in several biological functions, including the immune response.
Increasing evidence shows long non-coding RNAs in various immune cells — T-cells, B-cells, macrophages, and natural killer cells — are linked in autoimmune diseases like MS.
Previous studies have found increased levels of various immune-related long non-coding RNAs in the blood of RRMS patients compared to healthy controls.
For this study, researchers measured the levels of three specific long non-coding RNAs — the nuclear paraspeckle assembly transcript 1 (NEAT1), P21 associated ncRNA DNA damage activated (PANDA), and taurine-up-regulated gene 1 (TUG1) — in blood samples of 50 RRMS patients, and compared it to 50 age-matched healthy people with no history or clinical signs of neurologic or autoimmune disorders. All MS patients underwent treatment with interferon-beta.
Researchers looked specifically at how the levels of the three RNA molecules might correlate with MS features.
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?