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RRMS Onset Taking Place at Older Ages Over Past 50 Years

The first symptoms of relapsing-remitting multiple sclerosis (RRMS) have been appearing increasingly later in life, according to a Spanish study covering nearly five decades. From the 1970s through the 2010s, the average age at disease onset rose by more than 10 years in both men and women, its researchers…

Worsening of Disability Evident in Older Patients Who Stop DMTs

While older multiple sclerosis (MS) patients whose conditions are stable commonly stop using disease-modifying therapies (DMTs), a study indicates this decision can shortly lead to a marked disease worsening in a substantial portion of them. “Our results raise important questions about the accepted practice of discontinuing medications once MS…

OTC Melatonin Improves Sleep Quality in MS Patients, Trial Finds

Taking the hormone melatonin may increase overall sleep quality in people with multiple sclerosis (MS), a clinical trial found. The compound, available as an over-the-counter dietary supplement, was particularly effective at extending sleep time in patients. Of note, sleep time decreased with age, meaning that “younger participants may have…

Lesser Right-hand Dominance May Be Linked to More Severe MS

Inconsistently switching between hands for most common manual activities — or naturally choosing the left rather than the right hand — may be associated with more severe multiple sclerosis (MS), either in the form of younger age at diagnosis or progressive type, particularly in women, a small study suggests. These…

Moderate-to-severe Bowel Problems Found in 14.5% of Patients

Moderate-to-severe bowel dysfunction was detected in 14.5% of adult people with multiple sclerosis (MS), an Italian study reports. The prevalence of bowel dysfunction was increased in women and in patients with progressive forms of MS, higher disability, older age, and longer disease duration. Despite the prevalence of bowel dysfunction…

DMTs Underutilized in Younger Patients, Study Indicates

Nearly a third of people with multiple sclerosis (MS) who are younger than 40 are not being treated with disease-modifying treatments (DMTs), even though younger individuals are expected to get the most benefit from DMTs, according to a new study. “DMTs for MS are more frequently used at…

Fatigue Prevalence Remains High in MS Patients

The prevalence of fatigue continues to be high among people with multiple sclerosis (MS) despite significant progress over the years in therapies that change the course of the disease, a large survey study in Norway found. The findings also show that the frequency of fatigue is higher in…

Certain Factors Worsen Outcomes in MS Patients With COVID-19

People with multiple sclerosis (MS) who have more extensive mobility issues are more likely to have worse outcomes from COVID-19, a new study indicates. The study findings also indicate that COVID-19-associated outcomes are worse among MS patients who are Black, older, have heart-related diseases, and who were treated with…

Immune Cells’ Ability to Clear Myelin Debris Is Potential Therapeutic Approach for MS, Mouse Study Shows

Oral administration of trehalose — a sugar molecule found in plants and fungi and reported to have neuroprotective effects — eased symptoms and halted disease progression in a mouse model of multiple sclerosis (MS). These benefits were associated with a restoration of the ability of microglia (the brain’s immune cells) to break down…