T20K in Good Position to Become Preventive MS Treatment, Cyxone Says

T20K in Good Position to Become Preventive MS Treatment, Cyxone Says

T20K, Cyxone‘s lead compound for treating multiple sclerosis (MS), seems able to prevent or slow disease progression, according to data from preclinical studies. Based on these findings, the company is confident that T20K might become a prophylactic (preventive) medication for MS in the near future.

T20K is a unique compound derived from a plant protein. Researchers from the Medical University of Vienna (Austria) and the University Medical Center in Freiburg (Germany) were the first to show that T20K was able to block the activity of pro-inflammatory cytokines (molecules that mediate immune and inflammatory responses), such as interleukin-2 (IL-2), and reduce symptoms of MS in animal models of the disease without toxic side effects.

Preclinical studies carried out last year have shown how T20K is absorbed and distributed in the body. Based on these findings, researchers expect that the medication can be administered at low doses, every two weeks or monthly. They believe that preventive treatment with T20K may have a significant effect on the long-term quality of life for MS patients.

Results also showed that T20K is slowly eliminated from the body, meaning that at any given time very small amounts of the compound are in circulation, which reduces the risk of drug toxicity. This also means that T20K may be prescribed to patients immediately once they are diagnosed, or shortly after, to slow disease progression in such a way that the patient’s next disease flare-up would be delayed and possibly less severe.

Following this strategy, the company is confident that T20K will be in a good position to become a new prophylactic treatment designed to prevent or reduce the frequency of MS episodes, unlike other medications that are designed to treat active disease flare-ups.

“If T20K continues to demonstrate its effect in human studies, which we have no indications otherwise, we believe that this could transform the way we look at severe autoimmune diseases such as MS. Both how we treat the disease but also how patients perceive a diagnosis since their outlook would have changed,” Kjell G. Stenberg, CEO of Cyxone, said in a press release.

“We are excited to know more about [T20K] abilities in the upcoming clinical studies,” Stenberg added.

Cyxone is finishing the preparations to launch the first Phase 1 clinical trial to evaluate the effects of T20K in healthy volunteers. According to the company, the trial’s application will be submitted during the second quarter of this year. For now, current studies shall focus on determining the optimal dose regimen for T20K to halt disease progression and, at the same time, guarantee it is not dangerous to other vital body functions.

6 comments

  1. Tim C says:

    Sounds exciting! I like the terms “plant based” and “low toxicity”. My wife is taking a DMT that I will not name here, that takes years to expel from her system, and everyone I’ve seen that takes this medicine or prescribes it looks pasty skinned and unhealthy. The side effects are horrific, yet since her doctor prescribed it, and the FDA approved it, she will not entertain other treatment options. She is no longer able to open the packaging of aforementioned DMT, so as I dispense them to her at her request, I feel like I am taking part in something in her regimen that is not beneficial. This makes me sad. On a more optimistic note, Ms patients that have had fecal microbial transplants seem to show great benefits. Any one else research this? Not much of a pharmaceutical role in that, so it may never be allowed in the USA I fear. Thx for the article – this looks promising

    • MS patient x says:

      Hi Tim
      Just wanted to inform you that I have tried fecal microbial transplant or FMT in the UK in the Taymount Clinic with a terrible result. Im quite young and were actually able to walk and act without anybody knowing I had MS, but I chose FMT because it sounded so natural and harmless and I wanted to “remove” the last MS from my system since I have had great results before in taking chances with not waiting for finale approcal with methods that seemed harmless, e.g. high doses of vitamin D3 which still isnt recommended even though years of science have greencarded that and the body naturally converts 20 minutes of sun into at least 600 mcg of vitamin D3 in your body thus the recommended dosage of 5 mcg daily seems insanely low. Drifting off topic here, my point is that FMT drastically worsened my MS and walking ability making my limp know, not being able to walk and run with my son which I could before. Taymount Clinic refused to acknowledge their treatment as having anything to do with it even though I have had MS for 15 years prior to FMT with quite a stady course and just the days after treatment it drastically declined day by day. Results have also shown afterwards that we share around +60+ of our bacterias with close relatives (like blodtypes, just much more complex), so giving bacterias from coincidental, healthy donors, hardly seems like being the answer, which I am sure are the reason why it had such drastic outcome. (me being from Denmark, thus not having any relation to the UK donors) (e.g. with organ donors chances for a match is much higher if the donor have grown up in the same environment even though not being a relative, so chances are its similar with the microbiome)

      • Tim says:

        Thanks for the info! Very helpful to hear from others about these things. I am encouraged about the benefits of pre and probiotics as well as fermented foods on gut health, and it is much easier to eat some sauerkraut as opposed to flying oversees. I hope the best for your health and your family. Seems autoimmune conditions are becoming more prevalent then ever, and I hope treatments and knowledge of these challenges will increase as well!

  2. Gator2004 says:

    This sounds promising! I was diagnosed in Sept 2018 and Copaxone was helping me. My insurance switched me to generic and I have had horrible side effects and an exacerbation since. I am scared of the other DMT side effects so this sounds like a good option. I wonder if children of people with MS could take it for prevention. I am terrified my little daughter will get this and decided not to have any more children.

  3. Peggy Beeber says:

    Terry Wahls is an MD- that had gone from being a healthy, energetic MD- to doing her rounds from a tilt wheel chair over 4 year period. She decided to take charge of her own health- and, has been in remission for years now- on the plan she developed for herself, and then shared [with astounding results] with other MS patients. If you- or someone you know has MS- she has two books out- the first one:
    “The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles.” by Terry Wahls M.D. [Amazon; 4.6 out of 5 stars; 1,117 customer reviews]
    Her more recent book is her recipe book… MS is not a disease- but a reaction in the body. Which I believe we can control- and, this doctor maps out the path for those seeking- to be proactive in this process. [Whoever said that anything worthwhile would be easy.] Just knowing that there really is a way to reclaim one’s life is exciting- nothing to buy, except a book that’s inexpensive and offers a map to your own good health! [We all know someone with this diagnosis- many of us have close friends or family members with it.]

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