Amitriptyline for Pain Management in Multiple Sclerosis

Elavil (amitriptyline) is a tricyclic antidepressant. It is frequently used in low doses for multiple sclerosis to treat neuropathic or nerve pain in the arms and legs (burning sensations, pins and needles, stabbing pains) caused by damage to pain regulating pathways in the brain and spinal cord. Amitriptyline works by changing the way nerves react to pain in the central nervous system.

Amitriptyline comes in pill form and is ingested by mouth. It is usually taken one to four times a day, at around the same time every day.

Common amitriptyline side effects may include gastric disorders, mouth pain, unusual taste, black tongue, appetite or weight changes, urinating less than usual, itching or rash, breast swelling (in men or women), decreased sex drive, impotence, or difficulty having an orgasm.

This medicine comes with a black box warning (information that appears on a prescription drug’s label to call attention to serious or life-threatening risks) about increased risk of suicidal thinking and behavior in children, teenagers, and young adults with major depressive and other psychiatric disorders, especially during the first months of therapy or following changes in dosage.

Read the latest news about pain and multiple sclerosis.

Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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