Amitriptyline as a Treatment for Pain Management in Multiple Sclerosis
Aside from treating depression, some antidepressants can be used for pain management in multiple sclerosis (MS). Amitriptyline (Elavil) is a tricyclic antidepressant which works by blocking the effects of two neurotransmitters called noradrenaline and serotonin. Source: patient.info
Amitriptyline is taken orally and is used to treat multiple sclerosis patients who may be suffering from nerve pain in the limbs such as pins and needles, stabbing pains, or burning sensations. The drug changes the way that nerves in the central nervous system react to pain.
Possible side effects of the drug include a black tongue, mouth pain, strange taste in the mouth, appetite or weight changes, gastric disorders, less frequent urination, and sexual changes such as decreased sex drive, difficulty in orgasming, and impotence.
Less common but more serious side effects include the risk of suicidal thoughts in children, teenager and young adults who also suffer from depression or psychiatric problems. These usually occur during the first few months of treatment or after a change in dosage.
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