AMPYRA® (dalfampridine) extended release tablets, 10 mg, is the only prescription medicine approved by the FDA since January 20101 to help improve walking in adults with MS2. This was demonstrated in clinical trials that patients treated with Ampyra walked faster than those treated with placebo.
Walking (gait) difficulties (is among the most common debilitating problems in people with MS, and is related to muscle weakness, spasticity, balance, sensory deficit and fatigue)
Ampira is usually taken by mouth 10 mg twice daily, approximately 12 hours apart up to a maximum dosage of 20 mg daily.4
The most common adverse events reported with this medicine in people with MS were urinary tract infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain, problems with balance, multiple sclerosis relapse, burning, tingling, or itching of the skin, irritation in the nose and throat, constipation, indigestion, and pain in the throat.3
Ampyra should not be used in people with moderate to severe kidney disease. In people taking ampyra, their blood levels are related to those associated with the occurrence of seizures.3
Ampyra is a broad spectrum potassium channel blocker and it is unknown how it works. Animal studies showed an increase of electrical signals between neurons through inhibition of the potassium channels.4
There are no generic versions of Ampyra approved.5
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