AMPYRA®  (dalfampridine) extended release tablets, 10 mg, is the only prescription medicine approved by the FDA since January 20101 to help improve walking in adults with MS2. This was demonstrated in clinical trials that patients treated with Ampyra walked faster than those treated with placebo.

Walking (gait) difficulties (is among the most common debilitating problems in people with MS, and is related to muscle weakness, spasticity, balance, sensory deficit and fatigue)

Ampira is usually taken by mouth 10 mg twice daily, approximately 12 hours apart up to a maximum dosage of  20 mg daily.4

The most common adverse events reported with this medicine in people with MS were urinary tract infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain, problems with balance, multiple sclerosis relapse, burning, tingling, or itching of the skin, irritation in the nose and throat, constipation, indigestion, and pain in the throat.3

Ampyra should not be used in people with moderate to severe kidney disease. In people taking ampyra, their blood levels are related to those associated with the occurrence of seizures.3

Ampyra is a broad spectrum potassium channel blocker and it is unknown how it works. Animal studies showed an increase of electrical signals between neurons through inhibition of the potassium channels.4

There are no generic versions of Ampyra approved.5

Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.