Restoring ‘lost’ pathway of neuroprotection benefits MS mice
Treatment with the neuroprotective protein HB-EGF eased inflammation and promoted tissue recovery across various disease stages in a multiple…
Articles by Lindsey Shapiro, PhD
Eye tracking device for monitoring MS severity approved in Canada
Health Canada has approved the commercial use of ETNA-MS, a software-based medical device that uses eye tracking to noninvasively measure…
Unmet MS care needs prevalent among patients in Italy: Survey
Almost all of the nearly 700 people with multiple sclerosis (MS) in Italy who responded to a patient survey…
Astrocytes, much like immune cells, can drive inflammation in MS
A subset of astrocytes — a type of support cell for the central nervous system — has a form of immune-related…
S1PR modulators linked to seizure risk in MS trial meta-analysis
People with multiple sclerosis (MS) have a twofold higher risk of seizures compared with the general population, according to…
Antibodies against EBV viral protein help prevent infection in mice
Using antibodies against a viral protein that’s needed for the Epstein-Barr virus (EBV) to invade human cells was found…
Cell therapy using Tregs in MS headed to Phase 2 trials in Poland
The Polish biotechnology company PolTREG plans to launch Phase 2 trials testing its Tregs therapy — the T-cell-based treatment…
FDA declines to approve GA Depot as treatment for relapsing MS
The U.S. Food and Drug Administration (FDA) has decided not to approve an application seeking clearance of GA Depot…
Chronic inflammatory lesions linked to more aggressive MS in US study
The presence in the brain of chronic inflammatory lesions — called paramagnetic rim lesions (PRLs) — in people with…
Sanofi launches Phase 3 frexalimab trials after positive Phase 2 data
Bolstered by Phase 2 trial data showing that frexalimab safely reduces the number of brain lesions in people with relapsing…
Larger trials needed to evaluate intermittent fasting for MS: Review
An intermittent fasting (IF) diet may lead to immune and metabolic alterations that ease…
Nitric oxide metabolites in blood could aid diagnosis of MS: Study
Measuring levels of nitric oxide metabolites in the blood could be a diagnostic biomarker for multiple…
High-intensity interval training of similar benefit to moderate exercise
High-intensity interval training (HIIT) and a longer but more moderate exercise regimen seem to be of similar benefit to…
Access to MS care poorer for rural regions, select patient groups in US
Geographical proximity to neurologists and multiple sclerosis (MS) speciality care centers is lower for people living in rural regions…
In MS, diet low in wheat may ease inflammation, improve life quality
A diet low in wheat was linked to reductions in circulating inflammatory immune cells and improvements in pain-related life quality…
Floodlight smartphone app helps in MS but work is needed to boost use
A smartphone application called Floodlight Open may help in tracking areas of function in people with multiple sclerosis (MS),…
Synapses in CNS may be important in myelin production, per MS study
Junctions between nerve cells and certain cells called oligodendrocyte precursor cells, or OPCs, in the brain and spinal cord may…
Depression in pregnancy linked to autoimmune disease, especially MS
Women with a history of depression around the time they get pregnant are at increased risk of developing autoimmune diseases…
CNM-Au8 leads to clinical gains for RRMS patients in extension study
Daily treatment with CNM-Au8 led to sustained improvements in vision and cognition for people with relapsing-remitting multiple sclerosis (RRMS),…
FDA OKs Phase 2 clinical trial of KYV-101 for progressive MS
The U.S. Food and Drug Administration (FDA) has cleared a Phase 2 clinical trial to test Kyverna Therapeutics‘ cell-based…
Immune responses to ancient viral protein divide active, stable RRMS
Immune responses against an ancient viral protein called pHERV-W that’s encoded in the human genome are higher in relapsing-remitting…
Presence of damaged myelin may be more harmful than its loss: Study
The presence of damaged myelin — the fatty, protective substance surrounding nerve cells that’s lost in multiple sclerosis…
MRI activity, low doses linked to disease recurrence after cladribine
About three-quarters of multiple sclerosis (MS) patients given an under-the-skin formulation of cladribine had no disease activity or didn’t…
Smoking during pregnancy tied to raised MS risk in mothers, offspring
Women who smoked during pregnancy, and their offspring, showed a significantly higher risk of developing multiple sclerosis (MS) in…
Swank and Wahls diets seen to improve RRMS hand, arm dexterity
The Swank and Wahls diets — two dietary strategies often adopted by people with multiple sclerosis (MS) — were…
GlobeStar adds another partner for Project Amethyst clinical trial
Advanced Innovative Partners (AIP) has agreed to assist GlobeStar Therapeutics Corporation and SMI Healthcare in designing…
Stem cell transplant outperforms Lemtrada in MS treatment: Study
A stem cell transplant was found to be better than Lemtrada (alemtuzumab) for lowering disease activity and slowing disability…
Relapses, lesions in 1st year on oral DMT seen to help predict outcomes
A scoring system that accounts for relapses and MRI activity in multiple sclerosis (MS) patients during their first year on…
Study examines real-world side effects linked to dalfampridine
The most common real-world side effects linked to dalfampridine — sold as Ampyra and with generics available — are…
Psychological resilience found to link relapse fear, life quality in MS
A patient’s ability to cope with and recover from adversity — called psychological resilience — was found to impact the…