April 14, 2020 News by Marta Figueiredo, PhD Ocrevus Use Still Growing in Europe But Challenges on Horizon, Spherix Reports Prescriptions of Roche’s Ocrevus (ocrelizumab) among multiple sclerosis (MS) patients initiating or switching a disease-modifying therapy (DMT) continue to rise in Europe, according to a survey conducted by Spherix Global Insights. Ocrevus, an anti-CD20 monoclonal antibody administered directly into a vein, was approved in the European Union to treat active forms…
April 8, 2020 News by Marta Figueiredo, PhD Altering Gut Microbiota May Be Beneficial Prior to MS Onset, But Not After, Mouse Study Indicates Changing the gut’s microbial community (microbiota) with antibiotics prevented the development of multiple sclerosis (MS), but not its progression after the disease was established, data from a mouse model of the disease show. These findings support evidence that microbiota manipulations affect inflammatory immune responses involved in MS development, but…
April 6, 2020 News by Marta Figueiredo, PhD Biogen’s Plegridy or Avonex Use Possible in Pregnancy, Breastfeeding, FDA Says Plegridy (peginterferon beta-1a) and Avonex (interferon beta-1a), both by Biogen, may be used — if necessary — by women with relapsing multiple sclerosis who are pregnant or breastfeeding, the U.S. Food and Drug Administration (FDA) announced in updating prescribing information for these MS treatments. Due to the limited…
March 30, 2020 News by Marta Figueiredo, PhD CHMP Favors Zeposia (Ozanimod) as Oral Treatment for Active RRMS in EU The Committee for Medicinal Products for Human Use (CHMP) has recommended Zeposia (ozanimod) oral capsules to be approved in the European Union (EU) to treat adults with active relapsing-remitting multiple sclerosis (RRMS). Opinions released by CHMP, an arm of the European Medicines Agency (EMA), are generally accepted by the European Commission,…
March 30, 2020 News by Marta Figueiredo, PhD Way of Getting Nerve Cells to Restore Myelin-like Abilities Seen as Possible Researchers developed a way of reprograming cells to use synthetic materials — provided by the team — to create artificial, working structures within or about the cells. This approach may be a way to reprogram nerve cells to produce myelin-like protective polymers — large molecules made of many repeating…
March 26, 2020 News by Marta Figueiredo, PhD FDA Approves Zeposia (Ozanimod), Oral Therapy for All with Relapsing MS The U.S. Food and Drug Administration (FDA) has approved Zeposia (ozanimod) oral capsules to treat adults with relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS (RRMS), active secondary progressive MS (SPMS), and clinically isolated syndrome (CIS). Due to the COVID-19 pandemic, however, when it will arrive in clinics…
March 24, 2020 News by Marta Figueiredo, PhD Risk of Faster Progression in PPMS Tied to Older Age and Active Disease Older age at onset and evidence of active disease, like clinical relapses or inflammatory brain lesions, significantly increase the likelihood of faster disability progression in primary progressive multiple sclerosis (PPMS), a natural history study suggests. These findings — which included active disease being seen in 31% of the 178…
March 13, 2020 News by Marta Figueiredo, PhD #ACTRIMS2020 – Ofatumumab Self-injection Pen May Be ‘Very Attractive’ Option for Relapsing MS Monthly under-the-skin injections of Novartis’ investigational candidate ofatumumab show promise as a convenient, effective, and safe therapeutic option for people with relapsing multiple sclerosis (MS). Data from the ASCLEPIOS and APLIOS clinical trials showed that ofatumumab — currently under regulatory review for possible approval in the U.S. and Europe…
March 3, 2020 News by Marta Figueiredo, PhD #ACTRIMS2020 – EHP-101 Shows Promise in Early Studies; Phase 2 Trial Ahead Emerald Health Pharmaceuticals’ investigational cannabidiol-derived EHP-101 continues to show potential to ease inflammation and myelin loss (demyelination) — a hallmark of multiple sclerosis (MS) — according to data from healthy volunteers and a mouse model of MS. The data support the advance of EHP-101’s clinical development into…
February 13, 2020 News by Marta Figueiredo, PhD MS Patients Needing Feeding Tubes May Live Longer if Given Before Age 50, Study Finds Placing a feeding tube before age 50 in multiple sclerosis (MS) patients with dysphagia, or difficulties swallowing, may extent their life by more than two years, a study suggests. These findings may help doctors and patients with decisions about feeding tube use, but more work is needed to better understand…
January 29, 2020 News by Marta Figueiredo, PhD New Imaging Agent of Myelin for Earlier MS Diagnosis, Myeliviz, Entering Clinical Testing The U.S. Food and Drug Administration (FDA) has agreed to allow Myeliviz, an imaging agent of myelin — the protective layer that covers nerve fibers and is damaged in multiple sclerosis (MS) — to be evaluated in a clinical trial with healthy volunteers. Myeliviz, created by Case Western Reserve University researchers, has the potential…
January 21, 2020 News by Marta Figueiredo, PhD Mayzent Approved in Europe as First Oral Treatment for Active Secondary Progressive MS The European Commission has approved Novartis‘s Mayzent (siponimod) as the first oral treatment for adults with active secondary progressive multiple sclerosis (SPMS). Active SPMS is defined by the presence of evident relapses or the detection of inflammatory activity in brain lesions on imaging scans. “As the only indicated oral therapy proven for…
January 15, 2020 News by Marta Figueiredo, PhD Almost Half of MS Patients Change or Stop DMT Due to High Financial Burden, Survey Shows The high cost of disease-modifying therapies (DMTs) for multiple sclerosis (MS), and the challenging process of insurance approval, lead to treatment gaps or alterations, increased symptoms, and sacrifices in lifestyle, a survey from the National Multiple Sclerosis Society (NMSS) shows. “People with MS are paying the price, not…
January 14, 2020 News by Marta Figueiredo, PhD MS Progression Affected by Degree of Relapse Recovery and Timing of DMT Use, Study Says Recovering well after a first relapse and starting a disease-modifying therapy (DMT) immediately afterward considerably increases the likelihood of slowing progression in multiple sclerosis (MS), a study suggests. Its findings support relapse recovery as a critical factor for DMT initiation, and one that should be assessed routinely in MS…
January 8, 2020 News by Marta Figueiredo, PhD Study Links FTO Gene Mutation to Obesity, Increased Disability in MS Patients A common mutation in the fat-mass obesity (FTO) gene is associated with obesity and increased disability in people with multiple sclerosis (MS), according to a Kuwaiti study. The data, which showed no link between this mutation and an increased risk of MS, highlights the need for more studies about…
January 7, 2020 News by Marta Figueiredo, PhD Probiotics Show Potential to Prevent, Delay Development of MS, Study Finds Probiotics show potential to prevent and delay the development of multiple sclerosis (MS) by changing immune and inflammatory responses, according to a review study. Data further support the link between the gut’s microbial community (microbiota) and the central nervous system (brain and spinal cord), and neurodegenerative diseases. However, large-scale clinical…
November 20, 2019 News by Marta Figueiredo, PhD Pregnancy Does Not Change Long-term Course of MS, New Data Suggest Pregnancy does not lead to long-term changes in the disease course of multiple sclerosis (MS), new research suggests. This work, which emphasizes the importance of careful data analysis, supports studies disputing previous beliefs that pregnancy worsened or lessened the long-term disease course of MS. The findings were presented by Mar Tintore,…
November 12, 2019 News by Marta Figueiredo, PhD Long-term IFN-Beta Treatment Normalizes Immune Balance in RRMS, Study Shows Long-term treatment with interferon beta (IFN-beta) corrects the defective immune balance characteristic of people with relapsing-remitting multiple sclerosis (RRMS), a study has found. The study also identified more than 200 genes with significantly different activity between complete and partial responders to IFN-beta treatment, which could be used to identify which…
November 6, 2019 News by Marta Figueiredo, PhD Specific FOXP3 Mutation Linked to Greater Likelihood of MS in Brazilian Women, Study Reports A specific mutation in the FOXP3 gene, one already linked to multiple sclerosis in the Iranian population, was now also seen to increase the risk of MS in Brazilian women, a study reports. This mutation is also associated with higher-than-normal levels of TGF-β1, an anti-inflammatory molecule, a finding that requires…
October 30, 2019 News by Marta Figueiredo, PhD Unemployment Risk Factors in MS Vary with Age, Study Suggests Physical symptoms and poorer coping mechanisms are major risk factors for unemployment in younger and older people with multiple sclerosis (MS), while psychological problems have the greatest impact in middle-aged patients’ unemployment, a study suggests. These findings highlight that unemployment risk factors vary with age and call for interventions…
October 25, 2019 News by Marta Figueiredo, PhD Higher Intellectual Ability, Early-life Physical Activity May Protect Against Cognitive Impairment in MS, Study Suggests Higher intellectual ability and physical activity during childhood and adolescence may help protect against the development of cognitive impairment in people with multiple sclerosis (MS), an Italian study suggests. These findings, though preliminary, suggest that intellectual enrichment and early-life physical activity may reduce the likelihood of developing cognitive deficits…
October 22, 2019 News by Marta Figueiredo, PhD Endothelin-1 a Potential Biomarker of Severity and Recovery from Optic Neuritis in MS, Study Suggests Endothelin-1 (ET-1) — a molecule with potent blood vessel-narrowing (vasoconstrictive) properties — may be used as a biomarker of severity for optic neuritis in people with multiple sclerosis (MS), a small Italian study suggests. The molecule also may be a potential indicator of patients’ failure to recover…
October 10, 2019 News by Marta Figueiredo, PhD Blocking LRP1 May Halt Inflammation, Promote Remyelination, Mouse Study Suggests Blocking production of the low-density lipoprotein receptor-related protein 1 (LRP1) — involved in inflammatory and immune responses — specifically in myelin repair cells halts neuroinflammation and promotes myelin repair, a preclinical study shows. These results, from two mouse models of multiple sclerosis (MS), shed light on the underlying mechanisms…
September 9, 2019 News by Marta Figueiredo, PhD Inflammation Hijacks Myelin Repair Cells to Promote Immune Attacks, Study Shows Brain inflammation in multiple sclerosis (MS) hijacks immature myelin repair cells, not only preventing myelin restoration but also promoting sustained inflammation and immune attacks against myelin, a preclinical study shows.
September 4, 2019 News by Marta Figueiredo, PhD Targeting Inflammatory Th17 Cells to Slow MS Disability Possible with Fewer Side Effects, Study Suggests Scientists may have found a way to manipulate T-helper 17 (Th17) cells so as to lower their ability to trigger inflammation, delaying the onset of multiple sclerosis (MS) in a mouse model and slowing its progression without affecting the entire immune system. Their findings may lead to new treatments with fewer…
August 26, 2019 News by Marta Figueiredo, PhD Persistent MS-related Fatigue Linked to Damage in Specific Brain Regions, Study Finds Persistent fatigue in people with multiple sclerosis (MS) is associated with damage in specific areas of the brain, regardless of depression symptoms, a study shows. The study, “Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white…
August 6, 2019 News by Marta Figueiredo, PhD Phase 1 Study Finds T20K, Plant Protein-derived Compound for MS, Safe and Tolerable, Cyxone Says A Phase 1 clinical trial found T20K, Cyxone’s investigational plant protein-derived treatment for multiple sclerosis (MS), to be safe and well-tolerated in healthy men, and raising the possibility that it might work at low doses, the company announced. A next step is to develop an oral formulation for the…
September 6, 2018 News by Marta Figueiredo, PhD Tysabri Seen to Improve Cognition in RRMS Patients Over 2 Years in Retrospective Study Tysabri (natalizumab) was reported in a small retrospective study to significantly improve cognitive abilities in people with relapsing-remitting MS patients (RRMS) over two years of use. The study, “Improvement in Cognitive Function as Measured by NeuroTrax in Patients with Relapsing Multiple Sclerosis Treated with Natalizumab: A 2-Year…
September 4, 2018 News by Marta Figueiredo, PhD Spasticity Scales May Not Be Sufficiently Informative of Sativex Benefits in MS Patients, Small Study Suggests Spasticity scales may be insufficient to reflect the actual benefits of Sativex (nabiximols) treatment on spasticity symptoms in people with multiple sclerosis (MS), according to a small case series study. The results support the need to conduct a more extensive and functional examination to clarify treatment responses and help…
August 30, 2018 News by Marta Figueiredo, PhD Tecfidera, Gilenya Equally Effective, But More MS Patients Stop Tecfidera, Real-World Study Shows Tecfidera (dimethyl fumarate) and Gilenya (fingolimod) are equally effective in treating multiple sclerosis (MS), but Tecfidera shows higher rates of discontinuation, according to a real-world study. The study, “Discontinuation and comparative effectiveness of dimethyl fumarate and fingolimod in 2 centers,” was published in the journal Neurology Clinical…