Gilenya Could Help Treat SPMS by Countering Astrocytes, Study Says

Gilenya Could Help Treat SPMS by Countering Astrocytes, Study Says

Gilenya (fingolimod) a multiple sclerosis (MS) drug developed to target the immune system and control inflammation, can also reduce the negative action of astrocytes, further controlling inflammation, says a new study.

The article, “Sphingosine 1-Phosphate Receptor Modulation Suppresses Pathogenic Astrocyte Activation and Chronic Progressive CNS Inflammation,” appeared in the journal PNAS.  It brings new insight into the pathology of MS and may help in the design of novel anti-inflammatory therapies to treat the disease.

Astrocytes are brain cells usually known for their protective role toward neurons following a stroke and spinal cord injury. However, these cells can also damage neurons when in the presence of certain factors released by microglia (inflammation mediators in the brain).

Astrocytes are believed to help trigger secondary progressive multiple sclerosis (SPMS), a second stage of MS that follows relapsing-remitting multiple sclerosis (RRMS) and is characterized by neuronal loss and disease progression. Treatments for RRMS are ineffective against SPMS, and only a few existing therapies can target this form of the disease.

“One of the most important unmet clinical needs in MS is to design therapeutic approaches for the progressive phase of the disease,” Francisco Quintana, PhD, the study’s lead author and a researcher in the Ann Romney Center for Neurologic Diseases at Boston’s Brigham and Women’s Hospital, said in a news release. “And a key unanswered question related to that is, what are the biological processes that drive disease pathogenesis at this stage?”

Using a mouse model of SPMS and mouse and human astrocytes, researchers observed that Gilenya blocks the activity of a group of proteins called sphingosine-1-phosphate receptors (S1PRs), thereby suppressing inflammatory processes and neuronal death mediated by astrocytes, microglia, and other immune system cells.

Although Gilenya’s neuroprotective effect was not as strong as that reported for other drugs, the team believes its results indicate that this drug may at least improve certain aspects of SPMS.

Novartis, the maker of Gilenya, is currently carrying out a Phase 3 clinical trial (NCT01665144) that is investigating the effectiveness and safety of siponimod (BAF-312)  in SPMS patients. The treatment is an experimental immune system-modulating therapy designed to be a more selective sphingosine 1-phosphate receptor modulator than Gilenya, and is reported to be showing promising results so far. The study involves more than 1,600 patients in 31 countries, and is expected to conclude in late 2020.

Joana brings more than 8 years of academic research and experience as well as Scientific writing and editing to her role as a Science and Research writer. She also served as a Postdoctoral Researcher at the Center for Neuroscience and Cell Biology in Coimbra, Portugal, where she also received her PhD in Health Science and Technologies, with a specialty in Molecular and Cellular Biology.
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Joana brings more than 8 years of academic research and experience as well as Scientific writing and editing to her role as a Science and Research writer. She also served as a Postdoctoral Researcher at the Center for Neuroscience and Cell Biology in Coimbra, Portugal, where she also received her PhD in Health Science and Technologies, with a specialty in Molecular and Cellular Biology.

3 comments

  1. Mish says:

    On this drug now, because Tecfidera played havoc with my white blood cell count. But it makes my skin itch. Uncontrollably. Does anyone else have this problem??

  2. Stacy says:

    Have SPMS – been on G for 6 1/2 years with super low WBC counts – otherwise no other adverse side effects.
    Also – annual MRI’s have shown no new dz activity or progression. ?
    However, living in complete DENIAL for 25 yrs., resulted in a lot of collateral damage (innumerable brain lesions, a thumb sized black hole top of brain) that present themselves every day physically and cognitively.
    I count myself super-blessed to be living in these days when MS research is culminating at warp speed!

  3. Steve says:

    Been on Gilenya for about 4 years now and have leveled out on progression, no new lesions, a couple of minor relapses with not much effect. Very pleased with the drug

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