Throughout 2019, Multiple Sclerosis News Today brought you daily coverage of the latest scientific findings, treatment developments, and clinical trials related to multiple sclerosis (MS).
We look forward to reporting more news to patients, family members, and caregivers dealing with MS during 2020.
Here are the top 10 most-read articles of 2019, with a brief description of what made them relevant for the MS community.
A single dose of CD45-ADC, an investigational targeted therapy being developed by Magenta Therapeutics and Heidelberg Pharma for different autoimmune diseases, was capable of restoring the normal function of the immune system in mice models of MS, according to a study presented at the American College of Rheumatology (ACR) Annual Meeting. Combined with a transplant of a healthy immune system, the treatment delayed disease onset and halted progression. The potential treatment works by delivering amanitin — a natural poison — to overactive immune cells by targeting the protein CD45, which is found on these cells’ surface. By doing so, the compound specifically depletes the body of abnormally active immune cells. The plan is to gather more data to be able to move CD45-ADC into clinical trials. In the future, this potential treatment may deliver a “one-time, curative immune reset” to patients, company executives say.
Viral infections affecting the brain of mice early in life could worsen classic symptoms of MS, including brain lesions, later in life and at sites where the virus had resided before being cleared. Those early infections ‘imprinted’ a chronic inflammatory signature made of brain-resident immune T-cells, which produced a signaling molecule called CCL5. Blocking CCL5 using OB-002, an experimental treatment by Orion Biotechnology Canada, prevented the formation of brain lesions in a mice models of MS. The study provides clues on the potential link between viral infections in childhood and the risk of later developing MS, and offers “a clear rationale” to move OB-002 forward as a candidate therapy for the disease, researchers said.
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