Novartis‘ ofatumumab outperformed Aubagio (teriflunomide) at lowering the frequency of relapses and preventing disability progression among people with relapsing forms of multiple sclerosis (MS), a study based on clinical trial data reports.
The study, “Ofatumumab versus Teriflunomide in Multiple Sclerosis,” was published in The New England Journal Of Medicine.
Ofatumumab is an antibody therapy that works by targeting CD20, a protein found on the surface of B-cells, a type of immune cell. By binding to CD20, ofatumumab is thought to lead to the destruction of B-cells, which is thought to reduce inflammation in the central nervous system (the brain and spinal cord).
In the U.S., ofatumumab is approved to treat certain blood cancers under the brand name Arzerra. The medication is currently being reviewed by both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as a possible treatment for relapsing forms of MS.
Decisions are expected in September from the FDA and early next year from the EMA.
This study reports the results of two Phase 3 clinical trials — ASCLEPIOS I (NCT02792218) and ASCLEPIOS II (NCT02792231) — which directly compared ofatumumab (20 mg subcutaneous injections once a month) with Aubagio (14 mg oral tablets taken once daily).
Collectively, the trials enrolled 1,882 people with relapsing MS, which includes relapsing-remitting MS (RRMS) and active secondary progressive MS (SPMS). They were conducted at 385 sites in 37 countries; 946 patients were treated with ofatumumab, and 936 with Aubagio.
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?