December 5, 2023 News by Marisa Wexler, MS Trial testing metformin, alpha-lipoic acid in progressive MS set to start A new clinical trial in Australia, called PLATYPUS, will simultaneously test two medications that have already been approved for other conditions in people with progressive forms of multiple sclerosis (MS). The study, expected to launch in January, will use an adaptive design, meaning data will be analyzed as…
April 26, 2022 News by Marisa Wexler, MS Trial of Metformin-Clemastine Combo Enrolls First Patient The first participant has been enrolled in a new clinical trial that is testing whether an antihistamine in combination with a diabetes medication might promote the repair of the myelin sheath in people with multiple sclerosis (MS). The trial’s first participant, Annabelle, was diagnosed with relapsing MS over a…
August 5, 2021 News by Marisa Wexler, MS Metformin Seen to Aid Cognition, Brain Biology in MS Rat Model Treatment with the diabetes medication metformin was seen to lessen cognitive impairment, improve coordination, and normalize neuronal activity in a rat model of multiple sclerosis (MS). The study reporting these findings,Ā “Evaluation of the effects of metformin as adenosine monophosphate-activated protein kinase activator on spatial learning and…
February 5, 2021 News by Teresa Carvalho, MS MS Society of Canada Grant Supports Trial of Metformin in Young Patients Multiple Sclerosis Society of Canada have given CA$400,000 (about $312,500) to support a pilot clinical trial investigating the potential of metformin, a common diabetes therapy, to treat children and young adults with multiple sclerosis (MS). The Phase 1/2 feasibility trial (NCT04121468) is recruiting up to 30…
January 2, 2020 News by Ana Pena PhD Top 10 Multiple Sclerosis Stories of 2019 Throughout 2019, Multiple Sclerosis News Today brought you daily coverage of the latest scientific findings, treatment developments, and clinical trialsĀ related toĀ multiple sclerosis (MS). We look forward to reporting more news to patients, family members, and caregivers dealing with MS during 2020. Here are the top 10 most-read articles of…
October 14, 2019 News by Marisa Wexler, MS Metformin Works to Promote Remyelination in Ways Similar to Fasting, Study Says Metformin, a common diabetes treatment that works to mimic dietary fasting, was seen to promote remyelination in the stem cells of elderly rats, suggesting it may be useful in treating multiple sclerosis. “Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells” was published in…
October 11, 2019 News by Mary Chapman MS Society in UK Opens ‘Stop MS Appeal,’ Ā£100M Fundraiser to Better Treat Disease Through its Stop MS Appeal campaign, the United Kingdomās MS SocietyĀ seeks to raise Ā£100 million (almost $125 million) within the next decade to advance research and treatments that will stopĀ multiple sclerosis (MS) progression. Over the next three months, the organization will run an extensive advertising campaign…
August 22, 2019 News by Alejandra Viviescas, PhD Gene on X Chromosome May Be Reason Women at Higher Risk of MS, Study Says Females of certain species ā like humans and mice ā have a known ability to produce more of the geneĀ Kdm6aĀ than males because it’s located on the X chromosome, of which females have two.Ā Kdm6aĀ is also quite active in immune system T-cells, a study found, and silencingĀ it in a mice model…
March 31, 2016 News by admin Diabetic Oral Drugs Like Metformin Eased MS Symptoms in People with Both Diseases, Study Reports New research from Argentina explores the idea that controlling symptoms of type 2 diabetes (metabolic syndrome) can also beneficially impact multiple sclerosis (MS) disease progression. The study,“Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis,“ appeared March 7 in the journal…