migration

3-D Structure of CCR2 Receptor, While Bound to Its Inhibitors, Captured for 1st Time

Scientists unraveled the 3-D structure of a key receptor linked to inflammation in multiple sclerosis (MS) ā€” the CC chemokine receptor 2 (CCR2) receptor ā€” when it is bound to two inhibitor molecules simultaneously. This potentially important finding, which allowsĀ scientists to see how these molecules fit together, couldĀ aid inĀ developingĀ betterĀ therapeutics that…

#ECTRIMS2016 – Protein Seen as New Target in Preventing Brain Inflammation in MS

Researchers found that blocking a protein,Ā known asĀ integrin alpha 8, may workĀ to prevent inflammation in the central nervous system of patients with multiple sclerosis (MS). The results were revealedĀ in an oral presentation, ā€œIntegrin alpha8 is a novel mediator of T lymphocyte migration across the CNS barriers,ā€ atĀ theĀ 32nd Congress of theĀ European Committee…

#ECTRIMS2016 – Benefits of Gilenya in MS Also Appear Linked to Its Effects on B-Cells

Scientists recently reported additional mechanisms of action that may underlieĀ Gilenya (fingolimod) beneficial effects in relapsing-remitting multiple sclerosis (RRMS). The results were in an oral presentation, ā€œFingolimod therapy modulates B cell functions: reduces CXCR4-mediated migration and increases B cell -mediated anti-inflammatory cytokine profile,ā€ given atĀ theĀ 32nd Congress of theĀ European Committee for Treatment…