March 3, 2020 News by Ana Pena PhD #ACTRIMS2020 – IL-13 May Be ‘Attractive’ Target for Easing Inflammation in MS A signaling molecule of the immune system called interleukin 13 (IL-13) may modulate the function of key immune cells involved in multiple sclerosis (MS), and their migration through the barrier that protects the brain and spinal cord. IL-13 is an “attractive molecule” and a potential avenue for treating MS,…
September 19, 2018 News by Iqra Mumal, MSc Ceramides Play Role in White Blood Cell Infiltration of Central Nervous System in MS The synthesis and metabolism of fat molecules known as ceramides is linked to G-CSF signaling, which increases white blood cell infiltration into the central nervous system and results in inflammation in patients with multiple sclerosis (MS), a new study shows. The study titled, āThe relevance of ceramides and their…
May 17, 2018 News by Patricia Inacio, PhD Viral Infection Promotes Factor in T-cells Leading to Brain Tissue Destruction Infection with lymphocytic choriomeningitis virus triggers expression of a factor called TOX in immune cells strengthening their migration into the brain and promoting damaging effects, including inflammation and tissue destruction. These findings represent a new piece of the puzzle about the mechanism underlying autoimmune diseases Ā like multiple sclerosis (MS).
November 8, 2017 News by Iqra Mumal, MSc Blocking CXCR7 Receptor of Mature Monocytes Could Be New Therapeutic Strategy in MS The CXCR7 receptor present on mature monocytes ā a type of white blood cell ā may be a therapeutic target to alleviate the inflammation seen inĀ multiple sclerosis (MS) and similar disorders, a new study shows. The study, āFrontline Science: CXCR7 mediates CD14+CD16+ monocyte transmigration across the blood…
December 12, 2016 News by Patricia Inacio, PhD 3-D Structure of CCR2 Receptor, While Bound to Its Inhibitors, Captured for 1st Time Scientists unraveled the 3-D structure of a key receptor linked to inflammation in multiple sclerosis (MS) ā the CC chemokine receptor 2 (CCR2) receptor ā when it is bound to two inhibitor molecules simultaneously. This potentially important finding, which allowsĀ scientists to see how these molecules fit together, couldĀ aid inĀ developingĀ betterĀ therapeutics that…
September 16, 2016 News by Patricia Inacio, PhD #ECTRIMS2016 – Protein Seen as New Target in Preventing Brain Inflammation in MS Researchers found that blocking a protein,Ā known asĀ integrin alpha 8, may workĀ to prevent inflammation in the central nervous system of patients with multiple sclerosis (MS). The results were revealedĀ in an oral presentation, āIntegrin alpha8 is a novel mediator of T lymphocyte migration across the CNS barriers,ā atĀ theĀ 32nd Congress of theĀ European Committee…
September 14, 2016 News by Patricia Inacio, PhD #ECTRIMS2016 – Benefits of Gilenya in MS Also Appear Linked to Its Effects on B-Cells Scientists recently reported additional mechanisms of action that may underlieĀ Gilenya (fingolimod) beneficial effects in relapsing-remitting multiple sclerosis (RRMS). The results were in an oral presentation, āFingolimod therapy modulates B cell functions: reduces CXCR4-mediated migration and increases B cell -mediated anti-inflammatory cytokine profile,ā given atĀ theĀ 32nd Congress of theĀ European Committee for Treatment…