MS lesions

The online community for neurologists Neurology Times will feature special coverage focused on multiple sclerosis (MS) in celebration of MS Awareness Month, which is currently taking place in March. The online platform was designed to provide healthcare professionals with informational resources about several hard…

Researchers at the University of Copenhagen and Rigshospitalet in Denmark have for the first time developed an accurate method to measure apolipoprotein M (apoM), a protein that is involved in several diseases like diabetes but also arteriosclerosis and sclerosis, disorders characterized by the stiffening of structures usually by…

Image credit: Yaming Wang/Bernd Zinselmeyer A new study has shown that a protein called TREM2 may inhibit microglial repair of damaged myelin in multiple sclerosis. The study appeared in the Jan. 29 issue of Acta Neuropathologica. MS is characterized by the degeneration of myelin, a fatty…

The Strategic Pharma-Academic Research Consortium for Translational Medicine has awarded its first grants totaling more than $1.9 million to support research projects dedicated to autoimmune diseases. Among the recipients is researcher Yanjiao Zhou, Ph.D., who is leading a study at Washington University in St. Louis (WUSTL) focused on multiple sclerosis (MS), as…

A study from German researchers might help to determine how multiple sclerosis is assessed in treatment trials. Published February 6 in the journal PLoS ONE, the study is titled “Regression to the Mean and Predictors of MRI Disease Activity in RRMS Placebo Cohorts –…

Several renowned scientists working on multiple sclerosis (MS) recently joined forces to discuss and highlight the progress and knowledge gaps related to MS research, the prospects of finding a cure for the disease, and a strategy to reduce the burden the disease places on patients. A series of articles was published by the researchers in the…

Icometrix, a biotechnology company focused on unique projects for diagnosing and treating multiple sclerosis (MS) patients, has designed new software for the measurement of brain lesions and brain volumes and their changes over time. MS, a chronic and neurological condition that affects about 2.5 million people throughout the world, is often first detected in patients at…

Researchers have uncovered new information about myelin, a fatty substance that wraps around the axons of brain cells (neurons) allowing them to transmit information quickly from one cell to another. De-myelinating diseases in which the insulating wrap is damaged include multiple sclerosis, in which unpredictable loss of myelin causes…

Researchers from Canada and the U.S. have found that brains of young people with multiple sclerosis fail to develop fully. The article appeared November 5, 2014 in the journal Neurology entitled, “Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth.” Multiple sclerosis is caused…

What may be overlooked in relating to and caring for patients with multiple sclerosis is the fact that the neurodegenerative disease sometimes affects a person’s ability to properly convey and perceive emotion. According to the National Multiple Sclerosis Society (NMSS), while there is not…

A study entitled “Longitudinal Follow-up of a Cohort of Patients with Incidental Abnormal Magnetic Resonance Imaging Findings at Presentation and Their Risk of Developing Multiple Sclerosis” published in the International Journal of MS Care reports that asymptomatic patients accompanied by Magnetic Resonance Images suggestive of…

The National Multiple Sclerosis Society granted the 2014 Barancik Prize for Innovation in MS Research to Philip Laurence De Jager, MD, PhD, who is a neurologist at Brigham and Women’s Hospital, as well as an associate professor of neurology at the Harvard Medical School. The award, meant to…

For the first time, an antisense oligonucleotide has been shown to be effective in treating relapse-remitting multiple sclerosis. A phase 2a clinical trial of Antisense Therapeutics Limited’s ATL1102, a CD49d antisense drug, showed that the treatment quickly reduced brain lesions in RRMS patients following the start of therapy.

Researchers are continuing to make headway in discovering new insights into how MS works, which in turn could lead to next-generation therapies. A new study shows that in the early stages of multiple sclerosis (MS), plasma micro particles act as biomarkers as well as pathological factors that induce endothelial permeability and…

Any intervention that could help multiple sclerosis patients preserve long-term memory would likely be well-received. As suggested by a recent study from the Kessler Foundation, “Working Memory Mediates the Relationship Between Intellectual Enrichment and Long-term Memory in Multiple Sclerosis: An Exploratory Analysis of Cognitive Reserve,” one…

Loss of myelin, the fatty protective sheath around nerve fibers, is a characteristic of multiple sclerosis (MS). A new magnetic resonance imaging (MRI) study by a team of researchers has determined that people with MS lose myelin in the gray matter of their brains, and that the amount of loss…

A new study, entitled, “Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells” conducted at University of Lund, Sweden, published on PlosOne by the research group of Dr. Shahram Lavasani in collaboration with…

A dynamic research team composed of doctors and scientists recently completed and published a study that sought to gain a better understanding of walking impairment, as it is manifested in patients living with multiple sclerosis (MS), a neurodegenerative disease wherein the impulse-conducting myelin sheath is attacked by the body’s own…

Novartis has announced that it will present new analyses and redefined treatment goals for multiple sclerosis (MS) at the 2014 Joint Americas and European Committees for Treatment and Research in Multiple Sclerosis Meeting (ACTRIMS-ECTRIMS), which is taking place in Boston, between September 10 and 13. Novartis claims to have…

Fingolimod is a disease modifying therapy (DMT) used to treat relapsing remitting multiple sclerosis (RRMS) patients as well as patients who continue to present with relapses despite treatment with beta interferon drugs, and is the first oral medication to be approved by the U.S. Food and Drug…

The common symptom of fatigue experienced by multiple sclerosis (MS) patients may be caused by regional damage in the brain, according to research conducted at the Vita-Salute San Raffaele University in Italy and published in the journal Radiology. Scientists analyzed atrophies and lesions in the white matter and grey matter of 65…

Eight new drugs that are able to stimulate the nervous system were discovered by a research team at UC San Francisco recently. The team utilized a novel screening platform and examined the cellular effects of 1,000 chemical compounds. The scientists believe the discovery may impact the treatment of the tissue…

A new study may offer new insight on beneficial effects of “chronic cerebrospinal venous insufficiency” (CCSVI or CCVI) treatment for Multiple Sclerosis (MS) and certain other disease conditions. CCSVI is the controversial theory that blocked neck veins are a major factor in many MS cases proposed by Italian physician…

A team of magnetic imaging scientists led by Dr. Ravi Menon, PhD, at the University of Western Ontario’s Robarts Research Institute have developed a better way to track the progression of Multiple Sclerosis (MS) from its very early stages. The Robarts researchers used a technique called Quantitative Susceptibility…

Following the promising results of prior trials, Receptos, Inc., a biopharmaceutical company engaged in the treatment of immune and metabolic diseases, announced that the Phase 2 portion of the RADIANCE trial has met the primary endpoint, a reduction in MRI brain lesion activity in patients with relapsing multiple sclerosis…

snig / Shutterstock.com Following yesterday’s publication of “Multiple Sclerosis Management – A Changing Landscape 2013,” a report outlining ongoing goals and focus points for advancing MS drugs and treatments, as a result of a meeting of specialists in Vienna, Austria, a new article…

Another study, in what has become a succession of Canadian studies, has failed to detect a link between blocked neck veins and multiple sclerosis proposed by Italian physician and researcher Dr. Paolo Zamboni in 2008 (a report in the Lancet noted that this hypothesis was originally posed by…

A new study published this week in the Journal of the American Medical Association Neurology says that predicting disease evolution is becoming essential for optimizing treatment decision-making in multiple sclerosis (MS), in which pathologic damage typically includes demyelination, neuro-axonal loss, and astrogliosis. The study, entitled “Magnetic Resonance Spectroscopy…

Scientists at the Scripps Research Institute (TSRI), the University of California (UC), Irvine and The University of Utah report that mice crippled by an autoimmune disease similar to multiple sclerosis (MS) regained the ability to walk and run after a team of researchers implanted human stem cells…

New research work from GlaxoSmithKline presented by Daren Ausin, PhD, at the American Academy of Neurology’s 66th Annual Meeting has implications for individuals with relapsinig-remitting multiple sclerosis. The presentation detailed a study that used GlaxoSmithKline’s ofatumumab in 231 patients with relapse-remitting multiple sclerosis. Ofatumumab is an anti-B-cell antibody, and it…