June 21, 2022 News by Marisa Wexler, MS T-cells in Bone Marrow Work to Drive Inflammatory MS Attacks Unusual growth in anĀ immune cell classĀ called myeloid cells is evident in the bone marrow of people with multiple sclerosis (MS), and these cells likely contribute to the inflammation that drives the disease, according to a new study. Experiments in mice suggest that myelin-reactive T-cells can migrate to the bone…
February 11, 2022 News by Marisa Wexler, MS Bacteria-fighting White Blood Cell ‘Traps’ Tied to T-cell Inflammation Molecular “traps” made by neutrophils, a type of white blood cell, to fight bacteria may contribute to the excessive inflammatory activity of T-helper 17 immune T-cells, which are known to play a role in autoimmune diseases like multiple sclerosis (MS). Neutrophils are equipped with a number of biochemical tools…
October 29, 2020 News by Teresa Carvalho, MS Newly Discovered Type of Immune Cells May Be Key in Treating MS A recently identified group of immune cells saved damaged nerve cells from death and promoted nervous system repair, a new study suggests. This finding may represent new promise for treating neurodegenerative diseases such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). The study, “A new neutrophil…
February 25, 2020 News by Steve Bryson, PhD Age, Gender, Blood Glucose Affect Immune Cells’ Response to Tecfidera in RRMS Patients, Study Reports Immune cells from patients withĀ relapsing-remitting multiple sclerosis (RRMS) respond differently to Tecfidera (dimethyl fumarate) based on age, gender, and serum blood glucose levels, a study found.Ā The results suggest these patient-specific factors can modulate the response of immune cells, and should be…
May 31, 2019 News by Jose Marques Lopes, PhD Abnormal Activation of Neutrophils a Potential Therapeutic Target in MS, Mouse Study Suggests Targeting the excessive activation of immune cells called neutrophils, and the associated oxidative stress, may be a therapeutic strategy in patients with multiple sclerosis (MS), according to a mouse study. TheĀ study, āDeficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production,ā was…
September 19, 2018 News by Iqra Mumal, MSc Ceramides Play Role in White Blood Cell Infiltration of Central Nervous System in MS The synthesis and metabolism of fat molecules known as ceramides is linked to G-CSF signaling, which increases white blood cell infiltration into the central nervous system and results in inflammation in patients with multiple sclerosis (MS), a new study shows. The study titled, āThe relevance of ceramides and their…
September 2, 2016 News by InĆŖs Martins, PhD Inflammation Fighters in Blood Cells Seen to Attack in Entirely New Way To reach tissues infected with foreign agents, neutrophils, the body’s first line of defense, need toĀ travel through vessel walls ā and do so by switching on a class of adhesion receptors, called integrins, that bind to other adhesionĀ molecules at the surface of the capillary walls.Ā Now, in a recent paper published…
September 9, 2015 News by Patricia Inacio, PhD Discovery of Mechanism That “Guides” Immune System Cells to Injury Sites Could Benefit MS Research In a new study entitled āNeutrophil trails guide influenza-specific CD8+ T cells in the airways,ā researchers uncovered a key mechanism mediated by neutrophils that guides immune system cells to the site of an injury or infection. Moreover, this mechanism is crucial for immune cells to function properly…