People with multiple sclerosis have high levels of pro-inflammatory TH17 immune cells in their intestines that correlate with change in the micro-organism mix in their gut and the levels of their disease activity, a study reports.
Researchers said the findings suggest that diet, probiotics and therapies that regulate TH17 cells could help treat MS. Probiotics are supplements containing beneficial bacteria.
The study, “High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis,” was published in the journal Science.
Research has shown that TH17 cells, also known as T helper 17 cells, play a role in the development of MS. In fact, they were the first harmful immune T-cells to infiltrate the central nervous system, according to studies in animals
Where TH17 cells become activated has been unclear, however. Studies in mice suggested it was mainly in the small intestine. Research has also indicated that their activation increases the potential for a person to develop an autoimmune brain disease like multiple sclerosis.
An autoimmune disease occurs when the immune system, which defends the body against disease, decides that a person’s healthy cells are foreign, and attacks those cells.
Researchers decided to see if the findings in mouse models of MS applied to people with the disease.
They discovered a link between higher levels of TH17 cells in MS patients’ intestines and autoimmune brain problems. They also found a correlation between higher levels of TH17 cells and changes in patients’ gut microbiome.
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