Columns The MS Wire - A Column by Ed Tobias MS News that Caught My Eye Last Week: Treating MS with a Statin, Ocrevus, Remyelination MS News that Caught My Eye Last Week: Treating MS with a Statin, Ocrevus, Remyelination by Ed Tobias | September 24, 2018 Share this article: Share article via email Copy article link Phase 3 Trial in the UK Soon to Test Statin, Simvastatin, in Slowing SPMS Progression I’ve taken a statin medication for years to keep my cholesterol in check. Now, a study is getting underway to see if one statin pill can also be used to treat MS. It’s particularly encouraging that this med is being studied as a potential treatment for secondary progressive MS, a form of our disease for which treatments are very limited. Enrollment in the U.K. will continue into next year, and enrollment information is included in this article. A large Phase 3 trial getting underway at sites across the U.K. willĀ test the effectiveness of simvastatin, a widely used oral statin, in possibly treating secondary progressive multiple sclerosis (SPMS), the studyās sponsor,Ā University College London Hospitals (UCLH), announced. Discuss the latest research and news about MS in our forums! The study, the largest ever undertaken for SPMS in the U.K., is named MS-STAT2 (NCT03387670). Its researchers will investigate simvastatinās abilityĀ to slow or stop disability progression in 1,180 SPMS patients treated daily with the cholesterol-lowering medication,Ā or placebo, for three years. *** NICE Rules Against Bringing Ocrevus into NHS for Primary Progressive Patients in UK This story, out of the U.K., contains news that’s not good. The group that advises the National Health Service on which medications it can prescribe has decided that Ocrevus isn’t cost-effective. That’s a blow to people who are battlingĀ primary progressive multiple sclerosis and need every tool they can find to limit their progression. The National Institute for Health and Care Excellence, better known as NICE, issued a final decision against includingĀ Ocrevus (ocrelizumab) as a treatment for primary progressive multiple sclerosis (PPMS) in the subsidized public health system for England and Wales. The agencyās āfinal appraisal,ā which mirrors its draft June ruling, is based on the cost-effectiveness of theĀ GenentechĀ therapy ā its price versus its benefits as a PPMS treatment offered to patients using the publicly fundedĀ National Health ServiceĀ (NHS). *** Ocrevus Climbing as First-line DMT for RRMS Among Neurologists Surveyed in Spherix Report This report samples only a small group of neurologists, but it backs up what I’ve been seeing MS patients report on social media groups: Ocrevus is becoming a very popular disease-modifying therapy (DMT). That may be because it’s the only DMT approved in the U.S. to treat both RRMS and PPMS. It may also be because some patients are reporting a reversal of some symptoms. This report adds to my amazement at the decision in the U.K. not to make Ocrevus available to PPMS patients (as reported in the previous story). Eighteen months after its entrance into the U.S. market,Ā Genentechās Ocrevus (ocrelizumab) has become the monoclonal antibody of choice to treat patients with multiple sclerosis (MS), according to a survey of nearly 100 neurologists across the U.S. Self-reported use of Ocrevus for theĀ third quarter of 2018 surpassed Biogenās Tysabri (natalizumab) in this class of MS therapies for a first time, exceeding neurologistsā expectations of six months ago by 7.4 percent for this quarter, it reports. *** Fat Carrier Protein May Protect Nerve Cells, Help Myelin Regrow During MS, Research Suggests Is it possible that there’s a substance that can help regenerate the nerve fibers of the myelin sheath and also control brain inflammation? These researchers think so. But they also caution that they’re just beginning to study this. So, it’s an interesting read but nothing to get very excited about, yet. Apolipoprotein D (ApoD), a brain-produced carrier of fat molecules, seems to have a neuroprotective role and helps in the regrowth of myelin during multiple sclerosis (MS), a finding that may help develop new therapeutic approaches to fight the disease, new research shows. The study, āExpression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions,ā was published in the journal Frontiers in Aging Neuroscience. *** Print This Page About the Author Ed Tobias People say to write what you know and Ed Tobias knows about MS. He's lived with the illness since 1980, when he was 32 years old. Ed's a retired, award-winning broadcast journalist and his column combines his four decades of MS experiences with news and comments about the latest in the MS community. In addition to writing his column, Ed is one of the patient moderators on the MS News Today Facebook, Twitter, and Instagram sites. Heās also the author of āThe Multiple Sclerosis Toolbox: Hints and Tips for Living with M.S.ā Ed and his wife split their time between the Washington, D.C. suburbs and Floridaās Gulf Coast, trying to follow the sun. Tags Genentech, myelin, ocrelizumab, Ocrevus, PPMS, SPMS Comments Dorothy Levinson I would Iike to see a survey geared to MS patients receiving Ocrevus to determine how they feel about having the treatment. Reply Ed Tobias Thanks for the comment, Dorothy. Though it's not a survey you can read some of the experiences of people who are using Ocrevus in our MS forums area. There are also some Facebook groups of Ocrevus users where you can read a lot of first-person comments about this med. Ed Reply Dorothy Leviinson My husband, who was diagnosed sept 6, 1969, received his first, half dose infusions of Ocrevus past May/june. A few days after the second half dose he developed a very bad UTI and had to be hospitalized and given IV antiobiotics. Killing off part of his immune system made me very nervous. Why is it that this country seems to prefer administering medications that "treat" diseases instead of trying to cure diseases? And, the cost of these odrugs are exorbitant! So far I am not impressed with what I see. Dr. Terry Wahls' MS diet works better Reply Leave a comment Fill in the required fields to post. Your email address will not be published. Your Name Your Email Your Comment Post Comment
Apolipoprotein D (ApoD), a brain-produced carrier of fat molecules, seems to have a neuroprotective role and helps in the regrowth of myelin during multiple sclerosis (MS), a finding that may help develop new therapeutic approaches to fight the disease, new research shows. The study, āExpression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions,ā was published in the journal Frontiers in Aging Neuroscience. ***
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