Columns The MS Wire - A Column by Ed Tobias MS News that Caught My Eye Last Week: Stimulator for Spasticity, Tysabri Dosing Trial, Mobility Devices Contest, Stem Cell Phase 2 Trial MS News that Caught My Eye Last Week: Stimulator for Spasticity, Tysabri Dosing Trial, Mobility Devices Contest, Stem Cell Phase 2 Trial by Ed Tobias | January 14, 2019 Share this article: Share article via email Copy article link WeHealth, PathMaker Collaborating to Develop MyoRegulator as Noninvasive Treatment for Spasticity I’m one of the many people with multiple sclerosis (MS) for whom spasticity is a significant problem. This is a nonmedicinal approach to dealing with it. I hope it doesn’t take too long to make this electrical stimulator available and, once it is, that it doesn’t cost an arm and a (spastic) leg to buy. WeHealth by Servier and PathMaker Neurosystems have established a new partnership to develop and commercialize the first neuromodulation technology for noninvasive treatment of spasticity, the companies announced. … The MyoRegulator uses two pairs of disposable skin-surface electrodes that deliver synchronized stimulation into two sites along the neural axis, at the spinal outflow and peripheral nerve controlling the affected muscle. Join the MS News Today forums: an online community for people with MS and their caregivers. *** Biogen Starts Phase 3b Trial to Evaluate Tysabri Extended Interval Dosing in RRMS Patients One of the drawbacks of being treated with Tysabri (natalizumab) is the increased risk of contracting the brain disease progressive multifocal leukoencephalopathy (PML). The risk increases as the length of treatment extends past two years. However, some neurologists believe that the PML potential becomes less likely if the interval between doses is increased to longer than one month. (When I was treated with Tysabri my interval was increased from one month to two months after two years of treatment.) Now, Tysabri’s manufacturer is testing this concept in a clinical trial. Biogen announced the start of a global Phase 3b clinical trial to evaluate the efficacy and safety of extended interval dosing with Tysabri in patients with relapsing-remitting multiple sclerosis (RRMS). Results of the six-week dosing interval will be compared with the approved standard interval dosing regimen, which consists of intravenous injections (300 mg) every four weeks. *** Five Finalists Vie for $1 Million Prize in Mobility Unlimited Challenge Some pretty cool ideas are being worked on to help people with mobility challenges get around more easily. They include a bike-share type of service using electric scooters, an affordable electrical cuff that counters foot drop, an ultralight manual wheelchair that self-balances, and two exoskeleton projects. Five finalists remain in the running for the $1 million prize being offered in the Mobility Unlimited Challenge, a global competitionĀ to promote the development of innovative solutions for personal mobility devices. A panel of expert judges selected the finalists from among 80 applications submitted by teams from 28 countries. The projects included different technological approaches to overcome the limitations of mobility devicesĀ to help improve the mobility and independence of people with lower-limb paralysis, including multiple sclerosis patients. *** BrainStorm Expands Production of Autologous Stem Cell Therapy NurOwn for Phase 2 Trial in Multiple Sclerosis The United States needs to step on the accelerator when it comes to approving stem cell treatments for people with MS. This clinical trial, involving mesenchymal stem cells, will hopefully bring us closer to that day. BrainStorm Cell TherapeuticsĀ announced that the production of its therapyĀ NurOwn will be expanded to support upcoming clinical trials, namely a Phase 3 trial in amyotrophic lateral sclerosis (ALS) and a Phase 2 trial in progressive multiple sclerosis (MS). BrainStormās proprietary, stem cell-based technology called NurOwn consists of autologous bone marrow-derived mesenchymal stem cells, meaning cells from an individual that are reinserted into the same person. These stem cells generate molecules called growth factors that can help neurons survive longer at or near the site of injury or damage, and are being evaluated as a treatment for various neurodegenerative diseases. *** Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Multiple Sclerosis News Today or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to multiple sclerosis. Print This Page About the Author Ed Tobias People say to write what you know and Ed Tobias knows about MS. He's lived with the illness since 1980, when he was 32 years old. Ed's a retired, award-winning broadcast journalist and his column combines his four decades of MS experiences with news and comments about the latest in the MS community. In addition to writing his column, Ed is one of the patient moderators on the MS News Today Facebook, Twitter, and Instagram sites. Heās also the author of āThe Multiple Sclerosis Toolbox: Hints and Tips for Living with M.S.ā Ed and his wife split their time between the Washington, D.C. suburbs and Floridaās Gulf Coast, trying to follow the sun. Tags autologous stem cell transplant, Biogen, BrainStorm Cell Therapeutics, NurOwn, progressive multifocal leukoencephalopathy (PML), spasticity, Tysabri (natalizumab) Comments Dave When do you expect to see the myoregulator offered for sale to the public? Hopefully soon. I hope you donāt expect it to be in clinical trials for the next decade? Reply Ed Tobias Hi Dave, Unfortunately, I don't know any more than you do. If you click on the headline of this story, which will link you to the full story, you'll see that there isn't a lot of detail. In the final paragraph it says the company will "support an ongoing clinical trial underway at the Institut du Cerveau et de la Moelle EpiniĆØre in France." Sorry there isn't more. Ed Reply Vlad Kogan Hi. Very good and quality reporting. May I have your permission to use some of this content with the referral back to you on our site? https://www.usawheelchair.com/blog/ I'm sure people would like that. Thanks Reply Ed Tobias Vlad, Yes, linking to the column, with credit, is fine. Ed Reply Leave a comment Fill in the required fields to post. Your email address will not be published. Your Name Your Email Your Comment Post Comment
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