Osmotica Amends NDA for Arbaclofen ER to Treat MS Spasticity
Osmotica Pharmaceuticals has submitted an amended new drug application (NDA) to the U.S. Food and…
Articles by Joana Carvalho, PhD
Exposure to DMTs Does Not Increase Risk of Severe COVID-19 in MS Patients, Study Finds
Exposure to disease-modifying therapies does not increase multiple sclerosis (MS) patients’ risk of developing a severe form of COVID-19,…
1st Relapsing MS Patient Enrolls in Phase 3 Trial of Oral SAR442168
A first person has enrolled in Sanofi’s Phase 3 trial evaluating SAR442168, an oral BTK inhibitor intended to treat relapsing…
Adamas Stopping Further Work on ADS-5102 for Walking Problems in MS
Adamas Pharmaceuticals has decided to stop further clinical development of ADS-5102 (amantadine),…
Gilenya May Help Control Severe Respiratory Disease in COVID-19
Gilenya (fingolimod), which works to modulate immune system activity in multiple sclerosis (MS), may benefit people with severe…
Depression 2 to 3 Times More Likely in MS Patients Than Others, Study Finds
A likelihood of depression is two to three times higher in multiple sclerosis (MS) patients in the U.S. and…
Phase 3 Trial of GA Depot for Relapsing MS Advances With $20M Support
Mapi Pharma, supported by an additional $20 million investment from its partner Mylan, will continue a Phase…
ERT Acquires APDM With Goal of Better Data for Movement Disorder Trials
ERT, which specializes in clinical trial data collection, announced it has acquired APDM Wearable Technologies (APDM), a provider…
Switch From Tysabri to Other DMT Raises Relapse Risk, Study Finds
The risk of a relapse is two to three times higher in relapsing-remitting multiple sclerosis…
Prime Signs Agreement With EMD Serono to Improve Mavenclad’s Cost-benefit Value
Note: This story was updated on June 15, 2020, to clarify that the agreement allows for possible reimbursement for Prime’s…
2 Exercise Rehab Aids Soon Available to Patients in US via ReWalk Robotics
ReWalk Robotics is preparing to implement agreements allowing it to distribute in the U.S. two new neuro-rehabilitation devices…
Ofatumumab Lowers B-cell Counts and Helps Relapsing MS Patients Reach NEDA, Data Show
Ofatumumab (OMB157) elicits a strong and fast reduction in the levels of circulating immune cells in people with relapsing…
MS Diagnostic Criteria Should Be Changed to First Rule Out NMOSD, Study Says
Diagnostic guidelines for multiple sclerosis (MS) should be amended to first rule out the presence of neuromyelitis optica…
Cell Transplant Restores Myelin Production in Brains of Adult Mice in MS Model
Human glial progenitor cells — forerunners of nerve cells that protect and support neurons — transplanted into adult mice in…
FDA Grants Breakthrough Device Designation to Helius’ PoNS Device
The U.S. Food and Drug Administration (FDA) has granted breakthrough device designation to Helius Medical…
MMJ Can Ship Cannabis Products to US for Clinical Testing, Agencies Say
MMJ International Holdings announced that it has been given clearance to ship its cannabis-based products to the U.S. for use…
US Grants Patent to MedRhythms’ Proprietary Audio Engine Used in Walking Therapy Products
The United States Patent and Trademark Office has issued a patent covering the intellectual rights to MedRhythms’ proprietary…
Nimodipine Can Prevent Spasticity Following Spinal Cord Injury, Mouse Study Shows
Nimodipine, an approved medication to prevent brain damage caused by hemorrhage, can be used to prevent spasticity following a…
Scientists Build Map of Toxic Immune Cells Contributing to Neurodegeneration in MS
Scientists have built a map of the toxic immune cells that contribute to neurodegeneration in multiple sclerosis (MS). Their findings…
Tysabri Shows Safety, Effectiveness in Real-world RRMS Use: 10-year TOP Data
Tysabri (natalizumab) is safe and shows robust, real-world effectiveness at reducing the frequency of relapses in people  with…
Ursolic Acid, Compound in Fruit Peels, Promotes Myelin Repair, Early Study Finds
Ursolic acid, a compound found in some herbs and in the peels of certain fruits, promoted nerve cell repair…
Specialist Inpatient Rehabilitation Cost-effective for MS Patients in UK, Particularly in Advanced Disease
Specialist inpatient rehabilitation is a cost-effective strategy that can improve the clinical outcomes of patients with multiple sclerosis (MS),…
Ocrevus Lowers Progression Risk in More Disabled MS Patients, Study Suggests
For multiple sclerosis (MS) patients with considerable disability, Ocrevus (ocrelizumab) appears to lower the risk of continued progression…
Mix of Broad and Specific Language May Help in Talking About MS
Using a mix of broad diagnostic terms and more disease-specific ones may help physicians and patients to better communicate symptoms of…
Myelin Health Depends on Steady Supply of Lipids, Study Suggests
Continuous production of fatty molecules (lipids) is crucial to the maintenance of the myelin sheath that wraps nerve fibers…
Bone Marrow Transplant Can Replace Overactive Immune Cells, Preventing Inflammation in MS, Study Says
A bone marrow transplant can remove the majority of overactive immune T cells from the central nervous system…
Language Classes Promote Brain Health and Life Quality in RRMS Patients, Study Finds
Learning a second language can bolster the health-related quality of life and mental well-being of people with multiple sclerosis…
Tysabri May Promote Inflammatory B-Cell Activation in MS Patients, Study Says
Tysabri (natalizumab), an effective T-cell targeting treatment for multiple sclerosis (MS), seems to also promote the activation of pro-inflammatory immune…
FDA Approves Three Generic Versions of Novartis’ Gilenya for Treating Relapsing MS
The U.S. Food and Drug Administration (FDA) approved three generic versions of Gilenya (fingolimod) for the treatment of…
Signaling Protein of Intestines May Trigger Nervous System Inflammation in MS, Study Says
A signaling protein (Smad7) that usually blocks the activity of a molecule called transforming growth factor-beta (TGF-β) appears to be…