News

MS cell-based therapy PTG-007 wins patent protection in China

Poltreg will receive a patent in China that covers the administration of its cell-based therapy PTG-007 for multiple sclerosis (MS) via an injection into the spinal canal, or intrathecally. The method showed superior benefits compared with PTG-007’s intravenous infusion into the bloodstream in a Phase 1b/2a study of people…

ECTRIMS 2024: Tolebrutinib may target smoldering inflammation

Sanofi’s tolebrutinib significantly delayed disability progression, by 31%, and increased the rates of disability improvement compared with a placebo in people with nonrelapsing secondary progressive multiple sclerosis (SPMS), according to new data from the HERCULES Phase 3 clinical trial. The investigational BTK inhibitor also was found to significantly…

ECTRIMS 2024: MS relapse rates fall with 5 years on Briumvi

Continuous treatment with Briumvi (ublituximab) over five years was associated with low rates of relapses and confirmed disability progression among people with relapsing forms of multiple sclerosis (MS), according to analyses from the open-label extension (OLE) phase of the treatment’s ULTIMATE Phase 3 trials. Relative to patients who…

ECTRIMS 2024: Mavenclad sustains benefits in relapsing MS

A short course of treatment with Mavenclad (cladribine) can provide long-term reductions in disease activity and disability progression for as long as four years in adults with highly active, relapsing forms of multiple sclerosis (MS), according to new data from the MAGNIFY-MS studies. The majority of patients had…

‘Eating Well with MS’ program improves dietary behavior: Study

An online education program called “Eating Well with MS” improved the dietary behavior of adults with multiple sclerosis (MS), and was deemed in a study to be practical to complete, interesting, and valuable for patients. “Our study completion rates highlight the practicality of the intervention,” the researchers evaluating the…

Ocrevus Zunovo now approved in US to treat relapsing MS, PPMS

The U.S. Food and Drug Administration (FDA) has approved Ocrevus Zunovo (ocrelizumab and hyaluronidase-ocsq),Ā a subcutaneous, or under-the-skin, formulation of Ocrevus (ocrelizumab), for treating adults with multiple sclerosis (MS). The approval covers all the same indications as the original medication, including relapsing forms of MS ā€” namely…

Neufit’s MS Bootcamp offers intensive 3-day rehab experience

Neufit is encouraging people with multiple sclerosis (MS) to register for its upcoming MS Bootcamp, a three-day event that will showcase the company’s Neufit method for an intensive, specialized rehabilitation experience and connect patients to experts and a supportive community. The event will take place Nov. 8-10, at…

Trial tests cognitive rehab with VR-based exercise to boost memory

A clinical trial is evaluating whether combining a cognitive rehabilitation program with a virtual reality (VR)-based aerobic exercise regimen will improve learning and memory in people with multiple sclerosis (MS) and motor disability. Researchers expect the approach will show cognitive benefits via positive effects on a brain region called…

Tolebrutinib delays disability progression in nonrelapsing SPMS

Treatment with the investigational BTK inhibitor tolebrutinib significantly delayed the onset of confirmed disability progression in people with nonrelapsing secondary progressive multiple sclerosis (SPMS) compared with a placebo, meeting the primary goal of the HERCULES Phase 3 trial. A preliminary analysis of liver safety was consistent with previous…

Researchers identify mechanisms of dysfunctional Tregs in MS

Researchers uncovered a mechanism by which regulatory T-cells (Tregs), immune cells that keep the immune system in check and prevent its overactivity, become dysfunctional in people with multiple sclerosis (MS) and other autoimmune conditions. Tregs from MS patients exhibited increased levels of a protein called PRDM1-S that ultimately caused…

Higher infection risk, less disability worsening with rituximab in MS

Rituximab, which is sometimes used off-label for multiple sclerosis (MS), doubles the risk of hospital-treated infections, but may prevent worsening disability better than some approved disease-modifying therapies (DMTs), a Swedish study finds. Hospital-treated infections were significantly associated with a higher risk of relapse-independent disability worsening among relapsing-remitting…

Glial cells implicated in MS disease progression, development

Glial cells, which mostly support the function of nerve cells, play key roles in multiple sclerosis (MS) disease progression and development, according to a stem cell-based study. ā€œMost research and therapeutic strategies have so far focused on blocking the overactive immune system, but how cells in the brain itself,…

EU patent given to arsenic trioxide, aiming to treat RRMS

A potential treatment of relapsing-remitting multiple sclerosis (RRMS), arsenic trioxide (ATO) has been patented in the European Union based on findings in preclinical studies. Notice of an intent to grant patent EP18722530, titled ā€œMethod for treating relapsing-remitting multiple sclerosis using arsenic trioxide,ā€ was given by the European Patent…

Adult myelin-making cells display unique marker affecting activity

A specific epigenetic marker, or a chemical modification in DNA that alters gene activity, may explain why adult oligodendrocyte progenitor cells respond differently to therapies aiming to restore myelin than their neonatal counterparts, a study reports. The modification, called a lysine eight acetylation on histone H4, helps to regulate…