News

Berberine, plant compound, eases disease severity in MS mouse model

Treatment with berberine, a compound found in many plants, eased disease severity and showed anti-inflammatory effects in a mouse model of multiple sclerosis (MS), a new study reports. “These results confirmed that treatment with berberine efficiently improved the disease in the animal model of MS,” the researchers wrote, noting…

Ocrevus can be safe, effective for children with active RRMS: Study

Ocrevus (ocrelizumab) is a safe and effective treatment for patients under 18 with highly active relapsing-remitting multiple sclerosis (RRMS), a small study from Turkey suggests. Over about 2.5 years of the treatment, these pediatric patients experienced no relapses or MRI activity, and their disability level also improved, indicating…

Swallowing problems are common for MS patients, review study finds

Nearly half of multiple sclerosis (MS) patients experience swallowing difficulties, which is notably higher than rates seen in the general population, according to a recent review study and meta-analysis. Because swallowing problems, or dysphagia, can lead to serious, sometimes life-threatening, complications, it is important for patients to be routinely…

Mayzent, vitamin D combo alleviates MS signs in mouse study

Using Mayzent (siponimod) and vitamin D3 as a combination therapy was found to improve motor function and promote remyelination — restoring the damaged myelin sheath around nerve fibers —  in a mouse model of multiple sclerosis (MS). “Our results demonstrate for the first time the potential synergistic effects…

Sesh, MS Canada partner to help MS patients with mental health

To support the wellness journeys of Canadians living with multiple sclerosis (MS), digital healthcare company Sesh is partnering with MS Canada to provide free, unlimited access to its online mental health platform. The partnership allows patients to participate in virtual therapist-led support groups, and kickstarts research efforts…

Biosimilar Comparable in Safety, Efficacy to Tysabri in Phase 3 Trial

PB006, a biosimilar to Biogen’s approved treatment Tysabri (natalizumab), showed similar safety and efficacy as the original medication in people with relapsing-remitting MS (RRMS), according to data from a Phase 3 clinical trial. “The Antelope trial reported equivalence between [PB006 and Tysabri] treatment across efficacy, safety, and secondary…

Crowdfunding Campaign Launched for MS, Other Clinical Programs

FibroBiologics has launched an online crowdfunding campaign to support the development of potential therapies in the company’s pipeline and advance its clinical programs in multiple sclerosis (MS) and other diseases. The campaign was begun in collaboration with StartEngine, an equity crowdfunding platform that facilitates investments in startup companies.

Aubagio Significantly Lowers Plasma NfL Levels in TERIKIDS Trial

Aubagio (teriflunomide) can significantly reduce plasma neurofilament light chain (pNfL) levels, a biomarker of nerve cell damage, in children and adolescents with relapsing-remitting multiple sclerosis (RRMS). That’s according to a new analysis of data from TERIKIDS (NCT02201108), the Phase 3 trial that supported expanding Aubagio’s indication in…

MS Cognitive Problems Can Ease With Rehab, Mindfulness Training

Two alternative treatments for the cognitive challenges people with multiple sclerosis (MS) can face in daily life — cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT) — were found to helpful in a clinical trial. Patients randomized to either treatment approach in the REMIND-MS study had fewer…

LAPIX, FDA Meeting Sets Way for LPX-TI641 Clinical Development

Lapix Therapeutics has met with the U.S. Food and Drug Administration (FDA) to determine how to advance its investigational treatment candidate LPX-TI641 into clinical trials for autoimmune diseases such as multiple sclerosis (MS). The pre-investigational new drug (pre-IND) meeting is usually the first formal one companies seeking to…

Relapsing MS Therapy Briumvi Now Commercially Available in US

TG Therapeutics’ Briumvi (ublituximab-xiiy), a CD20 inhibitor recently approved for adults with relapsing forms of multiple sclerosis (MS), is now commercially available in the U.S., the company announced. The treatment was approved in the U.S. late last year, with indications that include clinically isolated syndrome, relapsing-remitting MS (RRMS),…

Fewer Women With MS Choosing to Stop DMT Use While Pregnant

The use of disease-modifying therapies (DMTs) by pregnant women with multiple sclerosis (MS) significantly increased over the last decade or so, and fewer of them are stopping treatment before giving birth, a single-center study in Italy reported. While most patients (95.1%) discontinued a DMT while pregnant between 2005…

Ocrevus Limits Progression Equally in Black, White People With RRMS

Ocrevus (ocrelizumab) seems to be equally effective at stabilizing disease activity in Black and white patients with relapsing-remitting multiple sclerosis (RRMS), a U.S. study found. Disability levels and MRI disease markers remained generally unchanged over the two-year study in both groups, despite Black patients having more severe disability…

Better Standards Needed for NICE Evaluation of MS Treatments: Study

In evaluating potential treatments for multiple sclerosis (MS) over the past two decades, England’s National Institute for Health and Care Excellence (NICE) made differing assumptions about whether and how the therapies’ effects will diminish over time. Such assumptions have a significant impact in estimating a therapy’s cost-effectiveness — a…

Key Myelin Protein Shows Promise as Biomarker for MS

The tiny sacs of cellular content that are released by oligodendrocytes — the myelin-producing cells of the brain and spinal cord — may be good biomarkers for the diagnosis and prognosis of multiple sclerosis (MS) patients, a new study has found. The research showed that levels of myelin basic…

NMSS Names New Jersey Facility Center for Comprehensive MS Care

The National Multiple Sclerosis Society‘s (NMSS) Partners in MS Care program has designated the multiple sclerosis center at Hackensack Meridian Jersey Shore University Medical Center as a Center for Comprehensive MS Care. With the designation, New Jersey now has two Comprehensive MS Care centers serving multiple sclerosis…

Smoking Linked to Depression and Anxiety in MS: Review Study

Smoking tobacco products is associated with a higher prevalence of depression and anxiety among multiple sclerosis (MS) patients, according to a recent systematic review. Across the evaluated studies, current smoking was linked to a 1.3–2.3 times higher prevalence of depression, and about a 1.2 times higher rate of anxiety.

Brain Circuit Associated With MS-related Depression Identified

Researchers have identified specific areas of brain damage associated with depression in multiple sclerosis (MS), but not with other symptoms of the disease. The findings could pave the way toward new treatments for MS-related depression that work to stimulate these regions. “The more we know about the connectivity of…