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Using a simple algorithm to recommend highly effective disease-modifying therapies (DMTs) for people with multiple sclerosis (MS) can help make treatment fairer for all patients, and level inequalities otherwise defined by race or ethnicity, a new study by U.S. researchers suggests. Indeed, use of the algorithm over a…

People with multiple sclerosis (MS) who switch from a high- to a moderate-efficacy disease-modifying therapy (DMT) increase their risk of disease activity, especially younger adults and those having inflammatory disease activity before a switch, a study finds. Knowing these factors “can help guide future studies on deescalation,” researchers…

People with multiple sclerosis (MS) who eat more fish are significantly less likely to see confirmed disability progression and the greater the intake, the lower the progression risk, a study in Sweden finds. The dietary habits of patients were assessed at the time of their diagnosis and disability progression…

Note: This story was updated March 6, 2025, to clarify the specific disability measures and results assessed in each trial. Sanofi’s experimental BTK inhibitor tolebrutinib may be more effective at reducing the risk of disability accumulation in people with multiple sclerosis (MS) who have evidence of paramagnetic…

A new model that combines genetic and symptom-based risk scores to predict the development of multiple sclerosis (MS) could help to accelerate the disease’s diagnosis, and allow patients to receive earlier treatment, a team of U.S. researchers noted in a study. In a presentation detailing this work at this…

Proposed revisions to the McDonald criteria, a set of diagnostic guidelines for multiple sclerosis (MS), may help diagnose people who could have been missed under earlier versions, according to a recent analysis. That includes people with radiological-only onset, when there are signs of disease on MRI scans but…

A neurodegenerative disease, multiple sclerosis (MS) is estimated to affect more than 1.8 million people worldwide — across all ages, races, sexes, and geographical regions. During Multiple Sclerosis Awareness Month this March, patients, caregivers, and other advocates are coming together to provide opportunities to connect, educate, inspire, empower, and…

Note: This study was updated March 3, 2025, to correct that a ketogenic diet is a low-carbohydrate, high-fat diet. Eating a version of the low-carbohydrate, high-fat ketogenic diet for six months led to an anti-inflammatory shift in immune cell populations among people with stable, relapsing-remitting multiple sclerosis (RRMS)…

Treatment with Ocrevus (ocrelizumab) may have a beneficial effect on paramagnetic rim lesions — known as PRL, these are a type of chronic inflammatory lesion — in people with multiple sclerosis (MS), according to a newly shared analysis. PRLs, a form of nerve damage seen in MS, have…

Immune cells from people with multiple sclerosis (MS) exhibit distinct gene activity just before patients have a disease relapse, according to recent research. The observed immune perturbations, which are no longer observed by the time the relapse is actively underway, are consistent with the body’s response to a reactivation…

A noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) doesn’t seem to ease fatigue in adults with multiple sclerosis (MS) when given at home with computer-based cognitive training, according to one of the largest studies of its kind. While the home-based intervention was deemed feasible, combining daily…

A statistical model that takes clinical and demographic factors into account could help guide treatment decisions in people with relapsing-remitting multiple sclerosis (RRMS) who haven’t yet started on a multiple sclerosis (MS) therapy, a study reports. “Our study offers a predictive tool that fulfills an unmet need for…

Over the past decade, diagnoses of multiple sclerosis (MS) in Finland have become faster and treatments now follow the latest evidence, with about five times as many patients receiving high-efficacy disease-modifying therapies (DMTs) as first-line options, a study finds. Drawing on registry data, researchers found that diagnoses are…

Tiziana Life Sciences is partnering with a contract development and manufacturing organization with expertise in intranasal drugs to accelerate the development and commercial launch of foralumab, a treatment designed to be sprayed into the nose. Tiziana’s medication is being investigated in an expanded access program (EAP) and a…

Antibodies against a protein found in neurons and in nerve supporting cells, may play a role in driving multiple sclerosis (MS), a study indicates. Researchers examined immune responses against more than 23,000 human proteins, and the MLC1 protein emerged as one of the top hit proteins targeted by immune…

Interactions between the body’s immune system and bacteria that live in the digestive tract — essentially, a person’s gut — become disrupted in multiple sclerosis (MS), a new study by U.S. researchers found. The human intestines are home to billions of bacteria and other microorganisms, collectively known as the…

Using an implantable scaffold to collect immune cells in mice, researchers have gained insights into the immunological mechanisms driving primary progressive multiple sclerosis (PPMS). Based on the findings, the scientists developed a treatment strategy to block specific inflammatory molecules, which eased MS severity in the mouse model. The study,…

Four more people with nonactive secondary progressive multiple sclerosis (SPMS) have received foralumab nasal spray — Tiziana Life Sciences’ therapy candidate for SPMS — via an expanded access program, the biotechnology company announced. That program allows patients who do not qualify for an ongoing Phase 2a clinical…

Using Ocrevus (ocrelizumab) as a first-line treatment for early-stage relapsing forms of multiple sclerosis (MS) is significantly better at delaying disease progression than starting with a less effective drug and switching to Ocrevus later. That’s according to nine years of data from the OPERA I (NCT01247324) and…

Switching from anti-CD20 medications to less effective fumarate therapies is linked to reduced healthcare visits and costs related to infections after a year, without affecting the rate of relapses in stable multiple sclerosis (MS). That’s according to an analysis of a U.S. healthcare claims database, which compared switchers against…

Relapsing-remitting multiple sclerosis (RRMS) patients with low educational attainment are more likely to delay the start of disease-modifying therapies (DMTs) after a diagnosis than those with a high educational status, a Danish study suggests. Educational status wasn’t significantly associated with diagnostic delays after the onset of symptoms,…

In a new deal, TG Therapeutics will use MaxCyte’s engineering technology to develop and manufacture its off-the-shelf CAR T-cell therapy candidate azercabtagene zapreleucel — azer-cel for short — for adults with progressive forms of multiple sclerosis (MS). The experimental treatment is being advanced toward a Phase 1…

Navigating the uncertainty of living with relapsing-remitting multiple sclerosis (RRMS) brings a number of challenges, a study shows. That uncertainty is best described as the intangible, difficult to define space between hope — the sense that things might get better or at least not turn out so badly —…

Children with multiple sclerosis (MS) who were exposed to sunlight for at least half an hour per day during the first summer of life tend to have less disease relapses than those who received less sun exposure during that period, a study found. The risk of relapse was also…

The Floodlight MS app, a digital health application used to track dexterity, walking function, and cognition in people with multiple sclerosis (MS), has been deemed cost-effective in a new analysis. Modeling simulations showed MS patients who use the app experience fewer relapses and slower disability progression, which would improve…

Experts in Australia and New Zealand have published the first consensus guidelines for the care of adults with multiple sclerosis (MS) in those countries, a step designed to help general practitioners and neurologists navigate the new MS treatment landscape. “Through these guidelines, we aim to support safe, timely and…

The rate of relapses in children with pediatric-onset multiple sclerosis (POMS) tends to increase around the time that menstruation begins, a new study reports. The findings suggest hormonal changes at the onset of puberty may trigger higher disease activity. The use of oral and infusion disease-modifying therapies (DMT)…

Smoking and obesity are both independently associated with faster disease progression in multiple sclerosis (MS), but when both risk factors are present together, a synergistic effect results in faster disease progression than can be explained by either alone. “Smoking and obesity significantly interacted to increase the risk of disability…

Nearly all adults with relapsing forms of multiple sclerosis (MS) said they are highly satisfied with the Sensoready autoinjector pen to self-administer Kesimpta (ofatumumab), according to a recent U.S. survey. High satisfaction was mainly driven by the reasonable administration time and ease of use, the researchers said. The…

A Phase 2 clinical trial is currently recruiting adults with relapsing types of multiple sclerosis (MS) to investigate Zenas Biopharma’s experimental therapy obexelimab as a weekly subcutaneous, or under-the-skin, injection, the company has announced in a press release. The study, called MoonStone (NCT06564311), is open to…