May 13, 2019 News by Marisa Wexler, MS #AANAM – Ocrevus Effective in RRMS Patients with Poor Responses to Other DMTs, Early Trial Data Suggest Early, one-year data from theĀ Phase 3 CHORDS study show that OcrevusĀ effectively prevents relapses and disease progression inĀ relapsing-remitting multiple sclerosis (RRMS) patients who have had poor responses to other disease-modifying therapies. These interim results were presented at the 2019 annual meeting of the American Academy of NeurologyĀ (AAN) in…
May 13, 2019 News by Patricia Inacio, PhD #AANAM – Aubagio at Higher Dose Shows Long-term Efficacy in Variety of Patients, Trial Data Show AubagioĀ taken as 14 milligram (mg) tablet once daily significantly reduces the risk of relapse in people with relapsing multiple sclerosis (MS) over time irrespective of their prior treatment history, a pooled analysis of Phase 2 and Phase 3 trial results show. The findings were presented at the 2019…
May 10, 2019 News by Marisa Wexler, MS #AANAM – Interferon Beta Exposure Does Not Seem to Increase Risk of Pregnancy Complications, Study Suggests Exposure to interferon beta does not seem to increase the risk of complications during pregnancy in women with multiple sclerosis (MS), new research suggests. The data were presented in an oral presentation, “Pregnancy and Infant Outcomes with Interferon Beta: Data from the European Interferon Beta Pregnancy Registry and MS…
May 10, 2019 News by Ana Pena PhD #AANAM – RRMS Patients Switching to Lemtrada Report Greater Satisfaction with Treatment and Improvements in Quality of Life Patients with relapsing-remitting multiple sclerosis (RRMS) who switched to infusions with Sanofi Genzymeās Lemtrada (alemtuzumab) report increased satisfaction with treatment and improvements in health-related quality of life, according to…
May 10, 2019 News by Ana Pena PhD #AANAM – Oral Ozanimod Better than Avonex in Lessening Brain Volume Loss in Relapsing MS, Trial Shows Oral treatment with ozanimod (RPC1063), an investigational immunomodulator under development by Celgene, is better at preventing brain volume loss, compared with Avonex (interferon-beta-1a), in adults with relapsing forms of…
May 9, 2019 News by Joana Carvalho, PhD #AANAM ā Adamas Provides Update on Phase 3 INROADS Trial Testing ADS-5102 for MS Adamas Pharmaceuticals announced the study design and baseline characteristics of patients enrolling in the company’s ongoing Phase 3 trialĀ testing the efficacy and safety of ADS-5102 (amantadine) extended-release capsules in patients with multiple sclerosis (MS) who have difficulty walking. The data were presented in a poster,…
May 9, 2019 News by Jose Marques Lopes, PhD #AANAM – Greater Exposure to Ocrevus Means Less Risk of Disability Progression in MS Patients, Study Contends Higher exposure to Ocrevus (ocrelizumab) is associated with greater immune B-cell depletion in the blood, and lessened risk of disability progression in patients with relapsing multiple sclerosis (MS) and primary progressive disease (PPMS), according to new research. The study supporting that finding, āPharmacokinetics, Pharmacodynamics and…
May 9, 2019 News by Jose Marques Lopes, PhD #AANAM – Scoring Tool Helps Identify Patients with RRMS or Transitioning to SPMS, Study Reports A newly developed scoring tool enables better identification of patients with relapsing-remitting multiple sclerosis (RRMS) as well as those transitioning or already diagnosed with secondary progressive MSĀ (SPMS). The research about that finding, āValidation of the Scoring Algorithm for a Novel Integrative Secondary Progressive Multiple Sclerosis (SPMS) Screening Tool,ā…
May 9, 2019 News by Jose Marques Lopes, PhD #AANAM – Mayzent Improves Cognitive Processing Speed in SPMS Patients, Trial Results Show Treatment with Mayzent (siponimod) provided sustained improvements and prevented deterioration of cognitive processing speed in patients with secondary progressive multiple sclerosis (SPMS), regardless of their cognitive function prior to therapy, according to results of a Phase 3 clinical trial. The data were presented at the recent 2019Ā American…
May 8, 2019 News by Ana Pena PhD #AANAM ā Quanterix Leads Research on Neurofilament Light Chain as Potential MS Biomarker Quanterix is leading the research presented at this year’s American Academy of Neurology (AAN) Annual Meeting, validating the use of neurofilament light chain (NfL) as a potential biomarker for the diagnosis, prognosis, and treatment monitoring of patients with multiple sclerosis (MS) and other neurodegenerative diseases. The company…
May 8, 2019 News by Marisa Wexler, MS #AANAM – Research Suggests Extended Interval Dosing of Tysabri Can Decrease Risk of PML New data suggests that treatment withĀ TysabriĀ (natalizumab) in an extended interval dosing regimen is associated with a significantly lower risk ofĀ progressive multifocal leukoencephalopathyĀ (PML) in patients with multiple sclerosis (MS), compared with the standard interval dosing. The data was presented byĀ Lana Zhovtis Ryerson, MD, on May 7 at the 2019Ā …
May 8, 2019 News by Marisa Wexler, MS #AANAM – Research Suggests Misconceptions About MS Risk in Pregnant Women New research suggests that even though pregnant women with multiple sclerosis (MS) are often viewed as high risk by their physicians, pregnancy Ā does not seem to increase the likelihood of adverse obstetrical outcomes for those patients or their babies. The research was presented at the 2019 Annual Meeting…
May 7, 2019 News by Jose Marques Lopes, PhD #AANAM ā Tysabri Lowers Serum Neurofilament Light Levels in SPMS Patients, Phase 3 Trial Finds Treatment with TysabriĀ (natalizumab) lowers the levels of the biomarker serum neurofilament light chain (sNfL) in patients with secondary progressive multiple sclerosisĀ (SPMS), according to data from a Phase 3 trial. Findings also revealed that higher levels of sNfL correlated with MS lesions and disease activity prior to starting the…
May 7, 2019 News by Jose Marques Lopes, PhD #AANAM – Mayzent Lessens Inflammation at Brain Meninges, Prevents Migration of Lymphocytes to Reduce Demyelination, Mouse Study Suggests Treatment with Mayzent (siponomod) may reduce myelin deterioration by lessening the accumulation of immune cells in brain meninges, and preventing the migration of pro-inflammatory lymphocytes into the brain, according to a study in a mouse model of multiple sclerosis (MS). The research, āA Mouse Model of…
May 6, 2019 News by Marisa Wexler, MS #AANAM – IV Therapy May Be More Effective Than Oral Treatment in Younger RRMS Patients, Research Suggests Infusible disease-modifying treatment ā that is, therapies given intravenously ā might have greater benefits for younger people with multiple sclerosis (MS) than oral ones, new research suggests. The research was presented at the ongoing American Academy of Neurology (AAN)’s annual meeting (May 4-10) by Brandi Vollmer,…
May 6, 2019 News by Mary Chapman Artists and MSAA Mark 10 Years of Showcasing Original Works A bird in flight, a field of flowers, a dog surrounded by butterflies, a portrait of a toddler ā they’re all part of the artwork by the multiple sclerosis (MS) community done for aĀ Multiple Sclerosis Association of America (MSAA) showcasing program, now marking its 10th year. Through its…
May 6, 2019 News by Marisa Wexler, MS #AANAM ā DMTs Primarily Responsible for Rising Healthcare Costs for MS Patients, Study Suggests A trend of rapidly increasing costs for disease-modifying therapies (DMTs) used to treat multiple sclerosis (MS) appear to be the primary driver behind the overall rise in healthcare costs for people with MS, a study suggests. These data were presentedĀ in a…
May 3, 2019 News by Mary Chapman MS Patient and Advocate āLonghaulpaulā Raises $18,500 for Disease Research and Patient Support As his moniker suggests, multiple sclerosis (MS) patient Paul Pelland is in it for the long haul. Known as “Longhaulpaul,” Pelland recently set a world motorcycling endurance record ā his third ā on a dynamometerĀ while raising $18,500 for MS research and patient support. Pelland rode his Yamaha Star Venture for…
May 3, 2019 News by Marisa Wexler, MS #AANAM – Precision Innovative Network and Splice Machine Will Present Predictive Healthcare Application at AAN Meeting A new clinical application prototype that uses machine learning to help physicians predict the best treatment options for patients with multiple sclerosis (MS) will be unveiled at theĀ American Academy of Neurology’s 2019 annual meetingĀ May 4ā10, in Philadelphia, Pennsylvania. The prototype is called PIN Population Data Platform. It has been…
May 2, 2019 News by Patricia Inacio, PhD Estrogen Promotes Remyelination in Adult Brains of MS Mice, Study Shows Giving estrogen to two different adult mouse models of multiple sclerosis (MS), including the experimental autoimmuneĀ encephalomyelitis (EAE) model, promoted remyelination, a new study shows. Exposure to the hormone affected gene activity in oligodendrocytes, tricking them into producing myelin (the fatty substance that protects nerve cells, and that is destroyed…
May 1, 2019 News by Joana Carvalho, PhD Women with MS Have Higher Prevalence of Sexual Dysfunction, Study Reveals Women with multiple sclerosis (MS) are more likely to experienceĀ sexual dysfunction and sexual distress than those without the disease, a study reports. According to researchers, the high prevalence of sexual problems among these women may be linked to their age, degree of physical disability, and depression. The…
April 30, 2019 News by Santiago Gisler Retrospective Study Analyzes Physical, Mental Differences Between Children with MS and ADS Retrospective comparison between children with multiple sclerosis (MS) and those with related acute demyelinating syndromes (ADS) highlights the implications of fatigue, depression, and quality of life in these patients. Those are the findings from a study, āFatigue, depression, and quality of life in children with multiple sclerosis: a…
April 30, 2019 News by Alice MelĆ£o, MSc Stem Cells in Mouse Hair Seen to Aid Growth of ‘Dense’ Myelin Sheaths Around Nerve Cells, Study Reports A subset of stem cells in hair follicles, called melanocytes, appear to do more than just give rise to mature melanocytes, cells that help to determine hair color. Those melanocyteĀ stem cells, or McSCs, that carry the CD34 protein were found in hair follicles from mice to differentiate into glia cells…
April 29, 2019 News by Alberto Molano, PhD Machine System Based on Brain Activity May Restore Speech to Those Who Lost It, Study Reports A study suggests that it may be possible to create synthetic speech based on recordings of brain activity in people with irreversible speech loss due to neurological ills, such as multiple sclerosis (MS), Parkinson’s, or stroke. The system uses tiny electrodes implanted on the surface of the brain thatĀ directly records…
April 29, 2019 News by Santiago Gisler Relapsing MS Patients Highly Satisfied with Aubagio’s Efficacy and Ease of Use, Global Clinical Study Finds High levels of satisfaction with the efficacy and convenience ofĀ Aubagio (teriflunomide), an oral treatment for relapsingĀ multiple sclerosis (MS), were reported by patients across the U.S. and 13 other countries, a post-hoc analysis of data from a real-world Phase 4 study found. The study “Teriflunomide real-world evidence: Global…
April 26, 2019 News by Alice MelĆ£o, MSc Active Form of Vitamin D Can Regulate Immune Responses in Diseases, Including MS, Study Shows An active form of vitamin D can modulate the activity of immune cells and prevent autoimmune reactions known to be involved in several human diseases such as multiple sclerosis (MS). A study with that finding, led by researchers from The University of EdinburghĀ in Scotland, reveals a new layer…
April 26, 2019 News by Marisa Wexler, MS Cellular Senescence Implicated in MS Development, Study Suggests Cellular senescence ā the process of aging at the cellular level ā may play a role in the development of primary progressive multiple sclerosis (PPMS) by limiting the ability of myelin-producing cells (oligodendrocytes) to renew and mature. The study with that finding, “Cellular senescence in progenitor…
April 25, 2019 News by Vijaya Iyer, PhD Aubagio Lowers Relapse Rate in RRMS Patients, Real-world Observational Study Shows In clinical practice, relapse events dropped by roughly half over a four-year period inĀ relapsing-remitting multiple sclerosisĀ (RRMS) patients treated withĀ Aubagio (teriflunomide), a real-world study reports. The study, āReal-life outcomes of teriflunomide treatment in patients with relapsing multiple sclerosis: TAURUS-MS observational study,ā also examined patients’ perspectives in…
April 24, 2019 News by Joana Carvalho, PhD MS Trust Promotes Multiple Initiatives in UK to Encourage Exercise The Multiple Sclerosis (MS) Trust, a charity organization that provides support to MS patients in the United Kingdom, is urging them to remain active and find ways to introduce physical activity into their daily routine, as part of its “Move it for MS” campaign. The organization’s…
April 24, 2019 News by Ana Pena PhD Thyroid Hormone Mimetic Holds Promise as Remyelination Therapy for MS, Mouse Study Shows Researchers have developed a compound based on the thyroid hormone T3 that is able to repair damaged myelin in the brain of mice, a discovery that holds promise for healing myelin loss in patients with multiple sclerosis (MS), results of an early study reveal.