Need to Know: MS and the Battlefield of the Immune System

Tamara Sellman avatar

by Tamara Sellman |

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Editor’s note: “Need to Know” is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum. Leave a comment here or at the original forum category.

I’m moved (and, truth be told, empowered) by the #HighRiskCOVID19 hashtag trending on Twitter. It’s spread to other social media channels, and I see a shift in commentary away from the original suggestion that “only” old and immunocompromised people are at risk.

If you have MS or another chronic condition, it’s not impolite to call out this ableist messaging — that somehow our lives matter less in the context of a majority presumed invulnerable. In fact, raising our voices against health privilege raises our visibility in a world that behaves as if we didn’t exist. This has to change; we need to be heard and valued. In the words of prominent disability activists, “Nothing about us without us.”

That said, many with MS may be unclear on how COVID-19 puts us at risk.

Let’s talk about what it means to be immunocompromised.

The immune system is a battlefield

The human immune system is an amazing kind of personal militia. It has:

  • reconnaissance units that patrol for combatants
  • soldiers that hunt down and capture invaders who cross our borders
  • a fleet of tanks and other weapons to destroy the enemy
  • a war room to model and test situations to use as a basis for defensive and offensive strategies

The goal, of course, is to win survive.

Honestly, I’m no fan of the idea of war, especially the reference to people with MS (or any chronic illness) as “warriors.” Not because I’m a peacenik, and not because I think people don’t fight back. Heck yes, we fight back!

I just don’t think we can overcome this disease through mind control alone. Our biology possesses an unknowable intelligence in the face of MS. We can only truly support our body — itself the battlefield — by nourishing our troops, keeping recon missions gassed up, implementing careful strategies in the war room (perhaps the only place we, as humans, can exert control), and maintaining our tanks and weaponry.

Immunocompromised means an impaired immune system

AboveMS offers a straightforward definition:

“The immune system works as a defense in fighting diseases or infections. Multiple sclerosis (MS) is an autoimmune disease. This means that the body’s immune system attacks its own body parts, such as tissue or nerves, instead of protecting them as it should.”

Essentially, your immune system is impaired. Either it’s shut down, or it’s overreacting.

Look at the word autoimmune. Auto means self; add this to immune and you describe the immune system attacking itself. In MS, the target is the myelin that coats the neurons in the central nervous system.

War metaphors help illustrate the fight

“Friendly fire” describes accidental attacks from within one’s own army. In a sense, having MS means facing friendly fire from our own immune system. Many good soldiers are attacking the wrong targets, to be metaphoric. Good immune cells, meant to disable invaders, mistakenly destroy healthy tissue instead.

Being immunocompromised also suggests we’re experiencing “chinks in the armor,” another war-born phrase to describe weaknesses that expose us as vulnerable. Other immune system soldiers mean to protect us against attacks, but they receive mixed signals or don’t see the attacks coming because they’re delivered by cells they’d normally trust. This invites a Trojan horse comparison.

In the case of untreated MS, our immune system behaves like a blitzkrieg during a flare, especially for those with progressive or severe illness. The attacks never stop. As our condition worsens, our disability increases. Having other illnesses, infection, or inflammation (hello COVID-19) only exacerbates these risks.

People treat their MS to stop this invasion. The problem? Disease-modifying drugs work by literally shutting down the immune system. From a field commander’s view, that’s the same as retreat. There are no defenses in line to protect against something like the flu or COVID-19.

It’s irrelevant whether we treat our MS; the immune system’s impaired either way, leaving us vulnerable to the virus. “Sheltering in place,” another military term, becomes our best strategy beyond vigilant self-care and strict hygiene protocols.

War is hell,” William Tecumseh Sherman once said, but I prefer author Tim O’Brien’s reference, because it’s not so black and white:

“War is hell, but that’s not the half of it, because war is also mystery and terror and adventure and courage and discovery and holiness and pity and despair and longing and love.”

Be safe out there.


Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Multiple Sclerosis News Today or its parent company, Bionews Services, and are intended to spark discussion about issues pertaining to multiple sclerosis.


Kevin Lipetzky avatar

Kevin Lipetzky

Immune systems: Is there any way to build my immune system and repair my Myilin?

Rose avatar


The term "Build up" in relation to immune system with MS, it is best to think "repair" rather than build up, if possible. Broken systems made stronger can be akin to further building your enemy's armories in wartime. I have found that the best course is to keep a balance through limited social activities where infections might be caught especially during cold and flu season. etc. Healthy diet, staying active as able physically. When I used to try and "build up" my immune system I was at my worst, now doing very much better just being diligent to keep a good balance. Good luck to you.

Maria avatar


I'm an RN whose unit was changed into a Covid 19 ICU. I was denied exemption from working there because my MS did not fit the criteria for being immunocompromised. This was even after my neurologist that has treated me for over two decades wrote that he recommends that I don't work until further notice. Not only do I have MS, but am over the age of 60. Does that make sense?

wendy smith avatar

wendy smith

I am not getting a direct answer I have multiple sclerosis am I immune compromised yes or no

Gill M avatar

Gill M

My son had type of benign MS. No symptoms really until after he contracted covid 19.During his covid illness,the doctor thought he had septicemia.He was given antibiotics.He was told it was caused by a cytokine storm where the immune system is triggered to attack his organs.He survived. Two months later the first of some very alarming symptoms appeared. He now has rapidly evolving MS and taking a chemotherapy drug. I am not a doctor but you do not want to contract covid 19 as it may trigger a worsening of your MS because your immune system is already malfunctioning and attacking your myelin sheaths. Practice frequent, efficient hygiene, wear a mask,and social distance. Good luck.

D. Elwood avatar

D. Elwood

I have the same question
as Wendy Smith. I have MS and told it was an autoimmune disease. On a form for my dentist I was asked if i have an immunocompromised condition. Do I answer yes or no?

D Goodwin avatar

D Goodwin

I think logically, sometimes to my detriment, and having MS (an autoimmune disease) seems to he the very definition of being immunocompromised. I know 3 people with MS that have died fast after contracting Covid 19 early on in the pandemic. All 3 got it in connection with their monthly infusion of their maintenance medication. I quit being in public in January 2020. Their plight cured me of not wearing a mask or contracting the virus because I stay home. I think that this definition is misleading at best. I dare to take matters of CYA into my own hands because the Republican state government where I live doesn't care to protect citizens just their hold on power.

Beth M Flood avatar

Beth M Flood

for the purpose of getting or not getting the Pfizer booster shot, is a person with MS considered immunocompromised ?

Bill Rapp avatar

Bill Rapp

Definitely tell the dentist that you have MS. MS people tend to have “pain in the face”
Lidocaine and the such can set off trigeminal neurologia
Now I have both.
Pardon the spelling.

Jan Langdon avatar

Jan Langdon

So since we are immune compromised, are we allowed to get a booster?

Laura Moster avatar

Laura Moster

MS itself does not make immunocompromised. In fact, MS causes your immune system to go into overdrive and attack the myelin of the nerves. If you take a disease modifying drug/treatment, that will cause your immune system to "calm down" in a sense, to the point where it can be considered compromised.

Deborah B avatar

Deborah B

It is funny... the "powers that be" define immunocompromised/compromised etc... I am 60 years young, fought MS over 20 years, took chemo over 3 years, fought non-epileptic seizures, asthma, hypothyroidism, high blood pressure, the doctor left part of the port-a-cathe in me and now it is part of my cell walls (if I remove it I could die, if they take it out I could die), had CORONA (COVID before they named it in Jan 2020); BUT I was told I had to wait to get my shot because I didnt fit the criteria (ha ha ha). Due to my race I actually had to go to another state to get the treatment and was on a ventilator in the hospital for 10 days and then another 2 weeks. I resigned from my HIGH paying job because I was afraid to go back into that pit of germs from travelling military... just to find I could not get unemployment. I suffered as a contractor with no life, health nsurance, and dwendling savings. THEN miraculously I was paid a lump sum of money in June 2020; BUT on Dec 31, 2020 my new years eve present was the state of maryland said it was a mistake and wanted the money back within 30 days (WHAT THE....?). I had to get a lawyer (so far cost me $6,000). I went to the news station AND it is still not resolved. Now the state says I owe $15,000 AND NOW the still paying the lawyers. I have been so sick with MS that I cant afford to fight. The stress of the MS has shut my system down so many times that my legs would not walk, I have shooting pains in my body, numbness and brain fog. I WAS engaged. EVEN SO... I am determined to not let MS or anything else beat me. They can call it what they want... immunocompromised... STAND STRONG! Keep your MIND sharp and calm so your BODY can follow. I pray for those of you who are suffering and your caregivers in whatever condition you are in. THANK YOU for letting me rant. I know you understand. GOD BLESS YOU ALL.


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