News Hypoxia-Measuring Technology in MS Could Be Potential Biomarker for Treatment Responses Hypoxia-Measuring Technology in MS Could Be Potential Biomarker for Treatment Responses by Patricia Inacio, PhD | November 16, 2015 Share this article: Share article via email Copy article link In a new study entitled āReduced cortical microvascular oxygenation in multiple sclerosis: a blinded, case-controlled study using a novel quantitative near-infrared spectroscopy method,ā a team of researchers at theĀ Hotchkiss Brain Institute, Cumming School of Medicine, University of CalgaryĀ investigated whether frequency domain near-infrared spectroscopy technology can measure the potential lack of oxygen (hypoxia) in brain grey matter regions of multiple sclerosis (MS) patients. The study was published in the journal Scientific Reports. Hypoxia (a term describing the insufficient concentration of oxygen in the blood and tissues) has been implicated in several diseases, including Alzheimerās disease and MS. Its role in brain disease pathogenesis is potentially linked to the hypoxia modulatory action of inflammation responses in the brain, a key step in MS (MS is an autoimmune disease that affects the brain and spinal cord; the disease is triggered by an inflammatory and immune attack to the myelin sheath, a protective layer that surrounds nerve cells). However, the study of hypoxia in the brain has been halted due to technological constrains. Frequency domain near-infrared spectroscopy (fdNIRS) is a system that quantifies microvascular hemoglobin saturation (StO2), a measurement that may be used as a potential marker of hypoxia in MS (98% of oxygen is transported in the blood mainly reversibly bound to hemoglobin, measuring hemoglobin saturation in brain small vessels indicates oxygen delivery efficiency and microvascular-associated performances). In this study, a team of researchers determined if reduced StO2 values were associated with the pathophysiology of MS. To this end, the team measured fdNIRS in a cohort of 72 MS patients (including relapsing remitting (RRMS), secondary progressive,Ā and primary progressive MS patients) and controls , focusing specifically in the brainsā grey matter. The researchersĀ detected that StO2 is reduced (more than 2 times) in SPMS and high disability RRMS patients, suggesting a relationship between StO2 and clinical disability in MS patients. These data also suggest that there may be hypoxic regions in an MS brain. As a result of these findings, researchers demonstratedĀ that fdNIRS technology is useful in the study of MS and other neurological disorders, and highlighted that measuring StO2 is a potential early response biomarker to assess treatment response in MS patients. Print This Page About the Author Patricia Inacio, PhD Patricia holds her PhD in cell biology from the University Nova de Lisboa, Portugal, and has served as an author on several research projects and fellowships, as well as major grant applications for European agencies. She also served as a PhD student research assistant in the Department of Microbiology & Immunology, Columbia University, New York, for which she was awarded a Luso-American Development Foundation (FLAD) fellowship. Tags autoimmune disease, brain, grey matter, inflammation
April 17, 2024 News by Steve Bryson, PhD NfL blood levels predict CIS to MS conversion: Clinical trial data
April 16, 2024 News by Marisa Wexler, MS Patients deem AI-based ChatGPT more empathetic than neurologists