These findings, which are consistent with those reported in a previous natural history study called NARCOMS, suggest an ascending order of motor function deterioration in MS patients, and may help in understanding the underlying mechanisms of MS progression.
The study, “Ten-year disease progression in multiple sclerosis: walking declines more rapidly than arm and hand function,” was published in the journal Multiple Sclerosis and Related Disorders.
Over the course of MS, people typically experience a decline in motor function. This can lead to impaired mobility, affecting walking and daily activities, and arm and hand dysfunction that could hamper the use of utensils and walking aids.
Data from NARCOMS, a natural history study following more than 35,000 MS patients in North America, showed that problems in mobility were more frequently reported (59%) than were those with hand function (40%) at 10 years following a diagnosis.
“The foregoing suggests that walking declines more rapidly than arm and hand function in [MS patients] in the years after diagnosis,” the researchers wrote.
Previous studies also suggest that MS-associated neurodegenerative processes start earlier in people with progressive forms of the disease than in those with relapsing MS.
“However, to date, no longitudinal cohort studies have directly compared the decline in leg function with arm function,” the researchers wrote, noting that whether these declines are more pronounced in a specific MS type also remains unclear.
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?