January 6, 2023 News by Marisa Wexler, MS Use of ‘Tattoo Gun’ Device Found to Greatly Reduce MS Severity in Mice Multiple tiny injections of myelin-related small proteins alongside suppressors of the activity of dendritic cells, done using a device akin to a tattoo gun, powerfully reduced the severity of multiple sclerosis (MS) in a mouse model of the disease. That’s according to new findings announced by Therapeutic Solutions…
February 4, 2022 Columns by Ed Tobias Taking Another Look at Vitamin D, Immune Tolerance, and MS I’ve been popping vitamin D pills for years ā decades, really. I never really understood why, I just knew that many people with multiple sclerosis (MS) are vitamin D-deficient. A recent study has cast some new light on why I should continue. It all seems to comes down to…
January 26, 2022 News by Marisa Wexler, MS How Vitamin D Modulates Immune System Activity Detailed in Study Vitamin D can influence the immune system’s tolerance to certain proteins by changing how DNA is packaged in specific immune cells called dendritic cells, according to a new study. Its findings could have implications for treating diseases like multiple sclerosis (MS) that are characterized by the immune system attacking…
August 4, 2021 News by Patricia Inacio, PhD Amino Acid MetaboliteĀ Shows Anti-inflammatory Potential A natural, small molecule called 3-HKA) has shown potent anti-inflammatory activity in lab tests and mouse models of immune-related diseases, a study found. The findings suggest that molecules that mimic 3-HKA (3-hydroxy-L-kynurenamine) may serve as broad-acting therapeutics to protect against inflammation in several autoimmune and inflammatory diseases, including multiple…
July 12, 2021 News by Steve Bryson, PhD Sugar Molecules in Yeast Cells Prevent Inflammation in Mouse Model A component of yeast cell walls ā called MGCP ā prevented disease in a mouse model of multiple sclerosis (MS) by activating anti-inflammatory immune T-cells while suppressing inflammatory T-cells, a study showed. This work also supporting the microbiomeās role in affecting inflammation in autoimmune diseases like MS. “We have…
November 11, 2020 News by Teresa Carvalho, MS Air Pollution, Once Inhaled, Seen to Trigger Inflammation in RRMS Patients Exposure to air pollution, particularly toĀ particulate matter 10Ā (PM10), small airborne and inhalable particles, may trigger inflammatory reactions in people withĀ multiple sclerosis (MS), an Italian study reported. The study “Air pollution as a contributor to the inflammatory activity of multiple sclerosis” was published in the Journal of…
March 2, 2020 News by Ana Pena PhD #ACTRIMS2020 – Protein May Drive Process Causing T-cells to Attack Myelin A protein called dedicator of cytokinesis 8 (DOCK8) is key for the development and expansion of self-reactive immune T-cells that wrongly attack myelin, a study in a mouse model of multiple sclerosis (MS) found. DOCK8 drives the migration and stimulating capacity of dendritic cells ā immune cells that ‘teach’…
January 17, 2020 News by Vanessa Pataia BioMed X, Merck Start Research Project for Autoimmune Diseases, Including MS BioMed XĀ announced a new collaboration with MerckĀ to create a joint research group to investigate the role of the intestinal epithelial barrier in the development and progression of autoimmune diseases, includingĀ multiple sclerosis (MS). The intestinal epithelial barrier is a physical border between the gut and the rest…
April 26, 2019 News by Alice MelĆ£o, MSc Active Form of Vitamin D Can Regulate Immune Responses in Diseases, Including MS, Study Shows An active form of vitamin D can modulate the activity of immune cells and prevent autoimmune reactions known to be involved in several human diseases such as multiple sclerosis (MS). A study with that finding, led by researchers from The University of EdinburghĀ in Scotland, reveals a new layer…
December 6, 2016 News by Patricia Silva, PhD Study Detailing New Way T-cells Attack Myelin May Explain Why Some MS Therapies Fail In a new and possibly important insight into the workings of the immune system, researchers discovered what it takes for T-cells to start targeting myelin sheets in multiple sclerosis (MS). The findings may also explain why some drugs fail to prevent autoimmunity in MS. The study, āTrans-presentation…
November 3, 2016 News by Patricia Inacio, PhD Lemtrada Targets Circulating Innate Immune Cells in RRMS Patients Lemtrada (alemtuzumab), a humanized monoclonal antibody, is able to remodel the immune responses of innate immune cells in patients with relapsing-remitting multiple sclerosis (RRMS), according to a recent study. This previously unreported phenotype may contribute to the benefits of the drug for RRMSĀ patients. The study, āAlemtuzumab…
May 23, 2016 News by InĆŖs Martins, PhD Relapses Prevented in Multiple Sclerosis Mouse Model Researchers at theĀ University of Heidelberg, Germany, recently showed that peripheral blood cells loaded with a drug that resembles the myelin protein are able to inhibit harmful immune responses and prevent relapses in a mouse model of relapsing-remitting multiple sclerosis (MS). The findings were described in the study “…
December 15, 2015 News by Margarida Azevedo, MSc Potential Multiple Sclerosis Therapy Seen in Addex’s mGluR4 Modulator Addex Therapeutics, a biopharmaceutical company developing novel small molecule allosteric modulators for neurological disorders, recently announced the publication of positive results from studies evaluating the therapeutic effect of ADX88178, a metabotropic glutamate receptor 4 (mGluR4)Ā modulator, in an animal model of multiple sclerosis. The research article, titled āAllosteric modulation…
November 5, 2015 News by Patricia Silva, PhD Autoimmune Disease, Obesity Link Found in Subset of Immune Dendritic Cells In a recent study published in the journal Immunity, researchers at the Weizmann Institute of Science in Israel reportedĀ the findings that a small subtype of immune dendritic cells plays a role in the prevention of both metabolic syndrome and autoimmunity. The study is entitled ā…