dendritic cells

Taking Another Look at Vitamin D, Immune Tolerance, and MS

I’ve been popping vitamin D pills for years ā€” decades, really. I never really understood why, I just knew that many people with multiple sclerosis (MS) are vitamin D-deficient. A recent study has cast some new light on why I should continue. It all seems to comes down to…

How Vitamin D Modulates Immune System Activity Detailed in Study

Vitamin D can influence the immune system’s tolerance to certain proteins by changing how DNA is packaged in specific immune cells called dendritic cells, according to a new study. Its findings could have implications for treating diseases like multiple sclerosis (MS) that are characterized by the immune system attacking…

Amino Acid MetaboliteĀ Shows Anti-inflammatory Potential

A natural, small molecule called 3-HKA) has shown potent anti-inflammatory activity in lab tests and mouse models of immune-related diseases, a study found. The findings suggest that molecules that mimic 3-HKA (3-hydroxy-L-kynurenamine) may serve as broad-acting therapeutics to protect against inflammation in several autoimmune and inflammatory diseases, including multiple…

Sugar Molecules in Yeast Cells Prevent Inflammation in Mouse Model

A component of yeast cell walls ā€” called MGCP ā€” prevented disease in a mouse model of multiple sclerosis (MS) by activating anti-inflammatory immune T-cells while suppressing inflammatory T-cells, a study showed. This work also supporting the microbiomeā€™s role in affecting inflammation in autoimmune diseases like MS. “We have…

Lemtrada Targets Circulating Innate Immune Cells in RRMS Patients

Lemtrada (alemtuzumab), a humanized monoclonal antibody, is able to remodel the immune responses of innate immune cells in patients with relapsing-remitting multiple sclerosis (RRMS), according to a recent study. This previously unreported phenotype may contribute to the benefits of the drug for RRMSĀ patients. The study, ā€œAlemtuzumab…

Relapses Prevented in Multiple Sclerosis Mouse Model

Researchers at theĀ University of Heidelberg, Germany, recently showed that peripheral blood cells loaded with a drug that resembles the myelin protein are able to inhibit harmful immune responses and prevent relapses in a mouse model of relapsing-remitting multiple sclerosis (MS). The findings were described in the study “…

Potential Multiple Sclerosis Therapy Seen in Addex’s mGluR4 Modulator

Addex Therapeutics, a biopharmaceutical company developing novel small molecule allosteric modulators for neurological disorders, recently announced the publication of positive results from studies evaluating the therapeutic effect of ADX88178, a metabotropic glutamate receptor 4 (mGluR4)Ā modulator, in an animal model of multiple sclerosis. The research article, titled ā€œAllosteric modulation…