February 12, 2024 News by Marisa Wexler, MS Immune cells in MS may enter brain via newly found ‘sewer system’ In neurological inflammatory conditions like multiple sclerosis (MS), inflammatory immune cells may enter the brain through arachnoid cuff exit (ACE) points ā newly discovered structures that normally seem to serve as a type of sewer system in the brain, helping to move out waste. Figuring out exactly how immune…
December 22, 2023 News by Andrea Lobo, PhD In pilot trial, Ocrevus failed to reduce MS inflammation in meninges Ocrevus (ocrelizumab) did not significantly reduce the number or volume of inflammatory lesions in the meninges in people with multiple sclerosis (MS), according to a recent pilot study. While inflammation in the meninges, the protective membranes that surround the brain and spinal cord, is thought to be driven…
August 5, 2022 News by Marisa Wexler, MS New 3D Brain Map May Help in Disease Management: Study A team of researchers has created a three-dimensional (3D) map of the lymphatic vessels that drain the brain, and demonstrated that these vessels are organized similarly in mice and in humans. The researchers propose measuring these vessels using MRI scans could “allow longitudinal imaging of disease progression that may be…
November 14, 2019 News by Joana Carvalho, PhD 7T MRI Reveals New Insights into Some RRMS Features With the help of 7 Tesla magnetic resonance imaging (MRI), investigators discovered that leptomeningeal enhancement ā a radiographic finding indicative of brain inflammation ā is more common than previously thought in people with relapsing-remitting multiple sclerosisĀ (RRMS), and is tied to lesions in specific regions of the brain.
May 7, 2019 News by Jose Marques Lopes, PhD #AANAM – Mayzent Lessens Inflammation at Brain Meninges, Prevents Migration of Lymphocytes to Reduce Demyelination, Mouse Study Suggests Treatment with Mayzent (siponomod) may reduce myelin deterioration by lessening the accumulation of immune cells in brain meninges, and preventing the migration of pro-inflammatory lymphocytes into the brain, according to a study in a mouse model of multiple sclerosis (MS). The research, āA Mouse Model of…
March 4, 2019 News by Jonathan Grinstein #ACTRIMS2019 – Cerebrospinal Fluid, Meninges Inflammation Profile Can Stratify MS Patients A method based on cerebrospinal fluid measurements and magnetic resonance imaging (MRI) can aid in stratifying patients with multiple sclerosis (MS) at the time of diagnosis, which may help identify a tailored therapeutic approach for each patient from early disease stages. The data was presented by Roberta Magliozzi, from…
September 20, 2018 News by Patricia Inacio, PhD Lymphatic Vessels of Brain Carry Messages That Appear to Promote MS, Study Reports Lymphatic vessels, the āroadsā that work to clear waste material from the brain, can also carry messages that direct immune system attacks against myelin, promoting the onset of multiple sclerosis (MS), new study shows. While the identity of these messages remains unknown, the findings suggest that blocking these signals could…
December 20, 2016 News by Patricia Silva, PhD Discovery of Brain-membrane Immune Cell May Advance MS Treatment Work The discovery of a new type of immune cell in the membranes covering the brain is likely to advance understanding of the immune system’s impact on the brain, a study says. It could also lead to new treatments for multiple sclerosis (MS) and other neurodegenerative diseases. Researchers knew the immune…
November 30, 2016 News by Joana Fernandes, PhD New Pool of Neural Stem Cells Found in Brain Meninges Could Lead to New Therapies for MS, Other Diseases Researchers have found neural stem cells (immature cells that can become neurons) in the meninges of the brain, a three-layer structure that protects the nervous system, according to results of a new study. The discovery of this pool of stem cells in the adult brain opens new possibilities for the…
December 17, 2015 News by Margarida Azevedo, MSc MS Study Uncovers a Process Leading to Neuroinflammation in the Brain In a new study, researchers from the University of Toronto, Canada, uncovered the process behind the formation and maintenance of tertiary lymphoid tissues (TLTs), structures found in the meninges in the brains of multiple sclerosis (MS) patients. Their findings, reported inĀ the article āIntegration of Th17- and Lymphotoxin-Derived Signals Initiates…
June 3, 2015 News by admin Approach to Treating MS May be Transformed Thanks to Newly Discovered Connection Between Immune-Nervous Systems An exciting new discovery has turned the medical world upside down, and could have important implications for the treatment of multiple sclerosis (MS). It turns out that previously undiscovered vessels exist that connect the nervous system and immune system directly. The study, titled “Structural and functional features…