August 5, 2022 News by Marisa Wexler, MS New 3D Brain Map May Help in Disease Management: Study A team of researchers has created a three-dimensional (3D) map of the lymphatic vessels that drain the brain, and demonstrated that these vessels are organized similarly in mice and in humans. The researchers propose measuring these vessels using MRI scans could “allow longitudinal imaging of disease progression that may be…
April 23, 2020 News by InĆŖs Martins, PhD Monocytes May Be Better, Safer Targets for MS Therapies, Study Suggests A subset of monocytesĀ (a type of immune cells) that can infiltrate the central nervous system and drive nerve cell damage in multiple sclerosis (MS) may be a better target for preventing disease progression than the cells of the immune system that are currently targeted with MS therapies,…
May 2, 2019 News by Patricia Inacio, PhD Estrogen Promotes Remyelination in Adult Brains of MS Mice, Study Shows Giving estrogen to two different adult mouse models of multiple sclerosis (MS), including the experimental autoimmuneĀ encephalomyelitis (EAE) model, promoted remyelination, a new study shows. Exposure to the hormone affected gene activity in oligodendrocytes, tricking them into producing myelin (the fatty substance that protects nerve cells, and that is destroyed…
March 14, 2019 News by Jose Marques Lopes, PhD Fatty Acid Pentanoate May Be Effective Treatment for MS, Other Autoimmune Diseases, Mouse Study Suggests Increased production of an anti-inflammatory molecule called interleukin (IL)-10, and suppression of a subtype of immune T-cells, may mean that a fatty acid called pentanoate is effective against inflammatory and autoimmune diseases such as multiple sclerosis (MS), according to new research in mice. The study, āThe…
January 10, 2019 News by Patricia Inacio, PhD Common Fungal Infection Can Breach the Brain and Impair Memory, Mouse Study Shows Blood infection with the yeastĀ Candida albicans,Ā a type of fungus, can reach the brain and trigger an immune response, a new mouse study shows.Ā Although the fungus can be cleared within 10 days, it affects the spatial memory of mice. These findings are the first evidence that a blood infection with a…
June 6, 2018 News by Patricia Inacio, PhD #CMSC2018 ā Inhibiting Oxidative Stress Enzyme Promotes Resealing of Blood-Brain Barrier in MS Mouse Model Inhibiting an oxidative stress enzyme called myeloperoxidase protects the blood-brain barrier in a mouse model of multiple sclerosis (MS), limiting the migration of immune cells and halting their attack on nerve cells, researchers have found. Disruption of the blood-brain barrier is a hallmark of various disorders, including MS, and when…
January 10, 2018 News by Jose Marques Lopes, PhD Stem Cell Combo Therapy Shows Efficacy in MS Mouse Model, Korean Study Shows A combination therapy of low-dose methylprednisolone and interferon (IFN)-beta-secreting stem cells is effective in a mouse model of multiple sclerosis (MS), a new Korean study suggests. The research, āEffective combination of methylprednisolone and interferon Ī²-secreting mesenchymal stem cells in a model of multiple sclerosis,ā appeared in the…
December 12, 2017 News by Patricia Silva, PhD Protamine, Anticoagulant Blocker, Seen to Aid Remyelination in Mice Within Limits Protamine āĀ an agent used to stop the anticoagulant effects of heparin ā was seen to trigger remyelination in mice with myelin damage. But while pointing a way forward for studies of myelin regeneration in multiple sclerosis (MS), the research team underscored that protamine itself is not an optimal treatment candidate.
June 16, 2017 News by Patricia Silva, PhD Tiny Particles Carrying Myelin Antigens Seen to Restore Immune Tolerance in MS Mice Model Researchers managed to change the immune system ā replacing inflammation with immune tolerance ā in a mouse model of multiple sclerosis (MS) using so-called quantum dots, orĀ nano-sized particles carryingĀ pieces of myelin. Experiments with this advanced technological solution may helpĀ researchers design MS therapies that are based on promoting regulatory T-cells rather…
January 6, 2017 News by Alice MelĆ£o, MSc Fusion Protein, CGEN-15001, Shows Ability to Restore Immune Balance in Mice with MS Compugen has reported new and promising results from studies onĀ animal models of multiple sclerosis (MS) that supportĀ itsĀ lead drug candidate, CGEN-15001, as a potentialĀ treatment for a variety of autoimmune diseases, including MS. Specifically, CGEN-15001 was shown to restore immune tolerance and balance in a durable and sustained manner in treated…
November 10, 2016 Columns by admin Research About Why Interferon Can Fail is Welcome I have made no secret of my distrust of the side effects from many of the disease-modifying therapies (DMTs) that are used mainly in the fight against relapsing multiple sclerosis (MS).Ā The fact that the most serious, albeit rare, side effects listed by the manufacturers of some drugs, include “death”…
October 14, 2016 News by Patricia Silva, PhD Regular Exercise Found to Repair Damage to Neurons in Brains of Mice Voluntary running triggers a molecule called VGF, a nerve growth factor,Ā that was seen to induce a brain repair mechanism in animals, researchers at The Ottawa Hospital and the University of Ottawa in Canada report. The findings have important implications for multiple sclerosis (MS) and other conditions caused by damage to…
June 7, 2016 News by Patricia Silva, PhD #CMSC16 – MS Mice Show Reduced Disease Severity After Treatment with Vegetable Compound Research from Indiana University School of Medicine showed that D3T – a compound that triggersĀ copyingĀ of antioxidant genes and production of the antioxidant glutathione – delays disease development and lowers disease severity in experimental autoimmune encephalomyelitis (EAE) animal models. The models mimicked multiple sclerosis (MS) in humans, advancing further exploration…