Myelin

March 23, 2018March 23, 2018

Emerald’s Cannabinoid-derived EHP-101 Enhances Remyelination in 2 MS Mouse Models

News

Emerald Health‘s investigational cannabidiol-derived EHP-101 reduces neuroinflammation, the risk of loss of myelin, and nerve cell damage in two mouse models of multiple sclerosis (MS), a new study shows. These ... Read more

March 19, 2018March 19, 2018

MS News that Caught My Eye Last Week: PPMS Treatments, Myelin Repair, the Blood-brain Barrier, Sunlight

Columns, The MS Wire - A Column by Ed Tobias

New Spherix Report Finds PPMS Treatment Increased Significantly in Past Year Primary progressive MS has, in some eyes, been the stepchild of the disease-modifying therapies. PPMS patients move steadily ... Read more

March 19, 2018March 19, 2018

Poorer Sense of Smell Can Be Evident Even in Early Stages of MS, Study Says

News

People with multiple sclerosis (MS) can indeed have a poorer-than-usual sense of smell, with problems possibly starting at early diseases stages, a small Turkish study reports. This work supports ... Read more

March 13, 2018March 13, 2018

Genetically Engineered Cells Have Potential to Restore Neuron’s Myelin Sheath, Study Shows

News

Genetically modified human umbilical cord blood cells can help nerve cells recover the myelin layer necessary for normal functioning, researchers found in a preclinical study. This finding may support ... Read more

March 13, 2018March 13, 2018

High Levels of Protein Can Disrupt Blood-Brain Barrier in MS, Study Finds

News

High levels of a protein called calnexin in the brain may disrupt the blood-brain barrier of patients with multiple sclerosis, a Canadian study suggests. The finding could lead to ... Read more

February 21, 2018February 21, 2018

University at Buffalo to Do Cognitive Training and Myelin Repair Studies

News

University at Buffalo researchers are working on ways to improve multiple sclerosis patients’ cognitive function and to repair damage to the mylein coating that protects nerve cells. The National Multiple Sclerosis ... Read more

February 19, 2018February 19, 2018

MS News that Caught My Eye Last Week: Stem Cell Trial, Medical Marijuana, Myelin Repair, Tysabri Study

Columns, The MS Wire - A Column by Ed Tobias

Stem Cell Treatment Benefits Three-fourths of MS Patients in Phase 1 Trial This is encouraging news for MS patients hoping to see some action in the stem cell area. ... Read more

February 16, 2018February 16, 2018

Inhibiting Enzyme Can Reverse Myelin Damage, Improve Limb Function, Mouse Study Shows

News

Inhibiting an enzyme responsible for turning genes on and off can reverse damage to the myelin sheath that protects nerve cells, improving limb function, a multiple sclerosis-related study in ... Read more

February 7, 2018February 7, 2018

#ACTRIMS2018 – Clene Nanomedicine Presents Positive Results for MS Remyelinating Therapy

News

Clene Nanomedicine says its pre-clinical studies demonstrate the remyelination effects of CNM-Au8, supporting its potential to treat multiple sclerosis (MS) and other demyelinating disorders. Clene presented its data in ... Read more

January 30, 2018January 30, 2018

FDA Approves Swedish Company’s Technology for Getting More out of MRI Scans

News

The U.S. Food and Drug Administration has approved technology that the Swedish company SyntheticMR developed to give doctors more information from magnetic resonance imaging scans. This means the company can begin ... Read more

January 22, 2018May 21, 2018

MS News that Caught My Eye Last Week: Ocrevus in the EU, Salt and Cognitive Problems, Searching for Myelin, Tecfidera Tolerance

Columns, Ocrevus, The MS Wire - A Column by Ed Tobias

European Commission Approves Ocrevus to Treat RRMS, PPMS Throughout EU This is a biggie. It’s been nearly a year since the FDA approved the use of Ocrevus here in ... Read more

January 16, 2018January 19, 2018

Myelin Loss Can Be Assessed With Innovative Imaging Approach, Study Suggests

News

A novel imaging approach enables assessment of key nervous system deterioration in multiple sclerosis (MS), a new study in mice suggests. The research, “Development of a PET radioligand for potassium ... Read more

January 10, 2018January 15, 2018

Stem Cell Combo Therapy Shows Efficacy in MS Mouse Model, Korean Study Shows

News

A combination therapy of low-dose methylprednisolone and interferon (IFN)-beta-secreting stem cells is effective in a mouse model of multiple sclerosis (MS), a new Korean study suggests. The research, “Effective combination ... Read more

January 9, 2018January 9, 2018

Cholesterol Buildup Limits Regeneration of Nerve-cell-protecting Sheath, Study Shows

News

The nerve-cell-protecting myelin sheath’s failure to remove cholesterol after the membrane has been damaged limits its ability to regenerate, German researchers report. Their finding has important implications for multiple ... Read more

December 18, 2017December 19, 2017

Cell Recycling Process Helps Trigger Immune Attack on Protective Nerve Cell Protein Myelin

News

A cell recycling process helps trigger an immune response against myelin, the protective layer covering nerve cell axons to aid in signal transmission, a multiple sclerosis (MS) study indicates. ... Read more

December 15, 2017December 15, 2017

Cambridge Researcher Wins 2017 Barancik Prize for Pioneering Work on Myelin Repair

News

A University of Cambridge researcher, Robin Franklin, has been awarded the 2017 Barancik Prize for Innovation in MS Research for his work on myelin repair and as a potential ... Read more

December 12, 2017December 14, 2017

Protamine, Anticoagulant Blocker, Seen to Aid Remyelination in Mice Within Limits

News

Protamine — an agent used to stop the anticoagulant effects of heparin — was seen to trigger remyelination in mice with myelin damage. But while pointing a way forward for ... Read more

November 28, 2017November 30, 2017

Immune Cells Use 2 Entry Points to Overcome Blood-brain Barrier and Attack Myelin in MS Mice

News

Immune cells that destroy myelin in multiple sclerosis access the brain and spinal cord via two different routes, a new mouse study shows. This suggests that therapies which target ... Read more

November 13, 2017November 9, 2017

MS News That Caught My Eye Last Week: Myelin Repair, MS Blood Test, Comparing DMTs

Columns, The MS Wire - A Column by Ed Tobias

Myelin-producing Brain Cells Regenerated Using Stem Cells in Early Study We know that when the myelin coating of our nerve axons is destroyed, MS symptoms result. So a process ... Read more

November 9, 2017November 9, 2017

The MS Alphabet: MRI, Myelin, mAbs, and Other ‘M’ Words

Columns, MS in Moderation, a column by Tamara Sellman

Editor’s note: Tamara Sellman continues her occasional series on the MS alphabet with this first of two columns about terms starting with the letter M. Symptoms of MS Memory ... Read more

November 7, 2017November 17, 2017

Targeting Blood-clotting Protein Can Restore Brain’s Potential to Repair Myelin Layer, Study Shows

News

A blood-clotting protein called fibrinogen prevents myelin production and blocks the neuron remyelination repair process in mice, a study finds. The study, “Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor ... Read more

November 6, 2017November 17, 2017

Thin But Persistent Regrowth of Myelin Layers Sign of Health in CNS, Study Says

News

The generation of a thin myelin sheath during remyelination — one that continues to protect nerve cells over time — is indicative of the long-term health and activity of ... Read more

November 2, 2017

MS Martial Arts: Battle B-neath the Surface

Multiple sclerosis is a progressive neurological disease that develops when the myelin in the central nervous system is attacked, leading to a range of symptoms including mobility problems, numbness, vision ... Read more

October 16, 2017October 16, 2017

MS News That Caught My Eye Last Week: Myelin repair, and Diets High in Fat or Salt

Columns, The MS Wire - A Column by Ed Tobias

Common Allergy Treatment Restores Protective Neuron Coating in MS, Trial Suggests This is the kind of news we all hope to hear. A treatment that will repair our frayed ... Read more

August 21, 2017August 22, 2017

Mouse and Human Myelination Research Might Improve Success Rates for New MS Treatments

News

Researchers at New York’s University at Buffalo have identified a gene that promotes the development of mature human myelin-producing cells — a discovery that may lead to new regenerative ... Read more

July 31, 2017May 21, 2018

MS News That Caught My Eye This Week: Myelin Repair, Ocrevus and Insurance, Cell Therapies

Columns, Ocrevus, The MS Wire - A Column by Ed Tobias

In case you missed them, here are some news stories that appeared in MS News Today that caught my eye over the past week: Q Therapeutics Approved to Start Trial ... Read more

July 26, 2017July 26, 2017

Q Therapeutics Approved to Start Trial of Cell Therapy Aiming to Restore Myelin

News

A cell therapy intended to boost myelin regeneration — Q-Cells by Q Therapeutics — has received a green light from the U.S. Food and Drug Administration to proceed with a clinical trial in patients ... Read more

July 17, 2017July 17, 2017

MS News That Caught My Eye This Week: Stem Cell Cautions, Myelin Mystery, Amprya Study and Zinbryta in the EU

Columns, The MS Wire - A Column by Ed Tobias

In case you missed them, here are some news stories that appeared in MS News Today that caught my eye over the past week. Experts Call for Tighter Regulation of ... Read more

July 13, 2017July 14, 2017

Dormant Herpes Virus Can Impede Repair of Myelin Sheath Whose Deterioration Causes MS, Study Reports

News

A herpes virus that lies dormant in many people can hinder the repair of the neuron-protecting myelin sheath whose deterioration causes multiple sclerosis, a study reports. The finding about the ... Read more

June 21, 2017

What Causes Multiple Sclerosis?

Despite being relatively well-known, there is often some doubt surrounding the causes of multiple sclerosis. According to the National MS Society, there are various factors which could contribute to someone ... Read more

June 16, 2017June 16, 2017

Tiny Particles Carrying Myelin Antigens Seen to Restore Immune Tolerance in MS Mice Model

News

Researchers managed to change the immune system — replacing inflammation with immune tolerance — in a mouse model of multiple sclerosis (MS) using so-called quantum dots, or nano-sized particles carrying pieces ... Read more

June 2, 2017June 2, 2017

Acne Therapy Reduces Rate of Multiple Sclerosis Progression, Canadian Study Reports

News

A common acne medicine called minocycline can reduce the rate of multiple sclerosis progression in patients who are at early stages of the disease, according to a Phase 3 clinical ... Read more

May 17, 2017May 17, 2017

PODS May Aid in Transporting Growth Factors for Treatment of Multiple Sclerosis, Other Diseases

News

PODS (POlyhedrin Delivery System), a new technology designed to transport any protein in the human body, may open up new approaches in treating multiple sclerosis (MS) and other diseases, says ... Read more

April 13, 2017April 13, 2017

3D Laboratory Cell Growth System Should Speed Up MS Remyelination Research

News

A physical scaffold that allows lab-grown brain cells to grow in a three-dimensional manner is giving scientists a whole new way of studying the regeneration of myelin, nerve coatings ... Read more

April 5, 2017April 5, 2017

UMD Team Reverses Paralysis in MS Mouse Model Using Novel Immunotherapy Strategy

News

Scientists at the University of Maryland have developed an experimental treatment to control the immune system and recover movement in a paralyzed mouse model of multiple sclerosis (MS). The team ... Read more

March 30, 2017March 30, 2017

MicroRNA Therapy Restored Myelin Production, Limb Function in MS Mouse Model

News

Using a small RNA molecule belonging to the family of microRNAs (miRs), scientists could restore myelin in nerve cells and improve limb function in mouse models of human multiple ... Read more

March 16, 2017March 16, 2017

Discovery of T-cells’ Role in Myelin Regeneration Could Lead to Therapies That Mimic Processes

News

Regulatory T-cells in the central nervous system trigger the maturation of stem cells that increase the production of myelin at injured neurons — a discovery that places the idea ... Read more

March 1, 2017March 1, 2017

People with MS Are Three to Six Times More Prone to Seizures Than Others, Study Reports

News

People with multiple sclerosis (MS) are three to six times more likely to develop epilepsy than the general population, a study says. Researchers believe the loss of myelin in ... Read more

February 27, 2017February 27, 2017

#ACTRIMS2017 – Epigenetics’ Role in Myelin Renewal Is Focus of Research

News

The absence of epigenetic factors in myelin-producing oligodendrocyte cells make sure that myelin production is switched off in the adult brain. Targeting these factors may be a way of ... Read more

January 23, 2017January 23, 2017

MS Researcher at Cleveland Clinic Awarded $7M to Pursue Ways of Stopping Myelin Damage

News

Two Cleveland Clinic researchers were awarded multi-year grants by the National Institutes of Health (NIH), under its Outstanding Investigator Award, to find new treatments for multiple sclerosis (MS) and other complex diseases. Bruce ... Read more