June 27, 2017 News by admin Tysabri Shows Long-term Safety, Efficacy in Japanese RRMS Patients, Study Shows A recentĀ study has found Tysabri (natalizumab) treatment for two years to beĀ efficient and safe in Japanese patients with relapsing-remitting multiple sclerosis (RRMS). The study, āSafety and Efficacy of Natalizumab in Japanese Patients with Relapsing-Remitting Multiple Sclerosis: Open-Label Extension Study of a Phase 2 Trial,ā appearedĀ in the journal…
June 26, 2017 News by Joana Fernandes, PhD RRMS Patients at Risk of PML Can Safely Switch from Tysabri to Lemtrada Lemtrada (alemtuzumab) may be an effective option for relapsing-remitting multiple sclerosis (RRMS) patients withdrawing from prior treatment with Tysabri (natalizumab), an Italian study shows. The study, āHigh-Risk PML Patients Switching from Natalizumab to Alemtuzumab: an Observational Study,ā appeared in the journal Neurology and Therapy. Tysabri, an antibody with…
May 30, 2017 Columns by Ed Tobias MS News That Caught My Eye: A New Study about Lemtrada, An Easy Way to Improve Balance, A New PML Case Reported and Kudos to Us Relapse after First Lemtrada Course No Indication of Poor Long-Term Outcome, Study Finds Some MS patients being treated with Lemtrada report new exacerbation after they complete round one of the drug, and they wonder if this means the drug isn’t working.
May 25, 2017 News by Patricia Silva, PhD PML Found in Ocrevus-Treated Patient Who Had Used Tysabri for 3 Previous Years A multiple sclerosis (MS) patient treated in Germany withĀ Ocrevus (ocrelizumab)Ā has developed the dreaded brain infection progressive multifocal leukoencephalopathy (PML).Ā But it is not clear whether the recently approvedĀ Genentech/Roche-developed treatmentĀ is the cause. The patient took the last dose of a three-year course of Tysabri (natalizumab)Ā in February. Tysabri is…
April 21, 2017 News by Alice MelĆ£o, MSc Decisions to Stop Taking Tysabri for MS Are Often Subjective, Study Concludes Many decisions to stop taking the multiple sclerosis treatmentĀ Tysabri (natalizumab)Ā appear to be based largely on subjective factors such as patients’ or physicians’ view of the risk, rather thanĀ objective assessments of the risk, a study indicates. TysabriĀ is an approved immunotherapy for active relapsing-remitting multiple sclerosis (RRMS). Despite its benefits, there…
January 16, 2017 News by Patricia Silva, PhD Early Detection of PML May Lessen Damage Done to MS Patients Using Tysabri Progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients treated with Tysabri (natalizumab) is linked to better outcomes if the condition does not give rise to actual symptoms and is diagnosed early. Limited brain lesions and moreĀ protective immune responses were also seen in patients who fared better, but researchers…
August 9, 2016 News by InĆŖs Martins, PhD Tysabri’s Success in Impairing the Immune System in RRMS May Be Source of Its Problems Although Tysabri (natalizumab) is a highly effective in treatingĀ patients with relapsing-remitting multiple sclerosis (RRMS), some may developĀ progressive multifocal leukoencephalopathy (PML). According to a new study,Ā this occurs because TysabriĀ impairs immune surveillance in the central nervous system and reactivates the latentĀ John Cunningham polyomavirus (JCV). The study, “Natalizumab Affects…
June 24, 2016 Columns by admin MS Patients Need a Drug Therapy Without Awful Side Effects Never having been offered, let alone received any disease modifying therapy, I can address the subject of disease modifying therapies, and their side effects, with complete impartiality. Of course, the reason for the lack of any medication is because none has yet been approved for use with MS patients who…
June 6, 2016 News by Patricia Inacio, PhD #CMSC16 – STRIVE Study Confirms Tysabri (Natalizumab) Safety in Early Relapsing-Remitting MS Results from the STRIVE study support the safety of natalizumabĀ (Tysabri) as a therapy for multiple sclerosis (MS) patients. The study, “Natalizumab in Anti-JC Virus Seronegative Patients with Early Relapsing-Remitting Multiple Sclerosis: Interim Results from the STRIVE Study,”Ā was recentlyĀ presented at the 2016 Annual Meeting of the Consortium of Multiple Sclerosis…
September 25, 2015 News by Patricia Silva, PhD Possible JC Virus Vaccination Offers Important Implications for MS Treatment Two studies recently published in the journal Science Translational Medicine, revealed a possible new vaccine treatment for JC virus with important implications for multiple sclerosis (MS) treatment. The studies are entitled āJC polyomavirus mutants escape antibody-mediated neutralizationā and āBroadly neutralizing human…
August 5, 2015 News by Patricia Silva, PhD Cases of Brain Infection Reported in MS Patients Taking Gilenya Multiple sclerosis patients prescribed Gilenya (fingolimod) are now being informed about a handful of documented cases where the therapy was found to have led to a rareĀ brain infection, according toĀ the US Food and Drug Administration. The FDA has released a public warning indicating thatĀ cases ofĀ progressive multifocal leukoencephalopathy (PML) have been…