research

Multiple sclerosis (MS) patients who interact with different sources of health information are more likely to adopt and maintain healthy lifestyle behaviors, a study has found. A combination of in-person interactive educational workshops and practical tools to implement these concepts in daily life may be the best strategy to…

The upcoming MSVirtual2020 meeting, the largest international conference dedicated to multiple sclerosis (MS) research, will focus on advances and breakthroughs made in MS causes and risk factors, diagnostic tools, treatment response biomarkers, technology, and therapies and interventions. The 8th joint meeting of the Americas Committee for Treatment and…

Immune B-cells are more abundant and have a pro-inflammatory profile in the cerebrospinal fluid (CSF), the fluid that bathes the central nervous system,  compared to blood in people with relapsing-remitting multiple sclerosis (RRMS), a study reports. The results suggest that therapeutic strategies targeting the CSF B-cells could constitute a…

Alterations in gut bacteria and bacterial metabolism were found in Japanese people at different stages of multiple sclerosis (MS) compared to healthy controls, a study reports. Reduced fatty acid synthesis in gut bacteria found in those with relapsing-remitting MS (RRMS)…

Migraine occurs in one third of people with multiple sclerosis (MS) and is more common among American and African patients, according to a review study. The data support previous findings suggesting this debilitating condition is more common in MS patients than in the general population. Further research is…

SomaCeuticals, a subsidiary of AngioSoma, has acquired exclusive global rights to a patented formula that aims to ease and possibly eliminate signs of neurodegeneration in people with multiple sclerosis (MS). By entering a licensing agreement with 7 to Stand, a Delaware corporation, SomaCeuticals gained access…

A comparison of immune cells isolated from identical twins — in which only one of each pair was diagnosed with multiple sclerosis (MS) — identified a population of immune-regulating T-cells present in those with asymptomatic brain inflammation, a study has found. …

Two specific bacteria present together in the gut led to more immune attacks on myelin and harsher symptoms in a mouse model of multiple sclerosis (MS). These findings add to existing evidence supporting the link between gut microbiota and MS, and highlight the need to consider potential combined effects of these…

Certain MRI measures of the brain and spinal cord directly associate with functional improvements in people with progressive multiple sclerosis (MS), a new study reports. According to BrainStorm Cell Therapeutics, these data will help in determining the benefits of NurOwn, the company’s stem cell-based…

Chemical modification of the protein eukaryotic elongation factor 1A1 (eEF1A1) regulates remyelination, a new study suggests, indicating that the processes regulating this protein may provide useful therapeutic targets for multiple sclerosis (MS). The study, “EEF1A1 deacetylation enables transcriptional activation of remyelination,” was published in Nature Communications.

Children with multiple sclerosis (MS) recover more quickly and “significantly better” from relapses than do adults — patients with disease onset at age 18 or older, researchers reported. The study, “Improved relapse recovery in paediatric compared to adult multiple sclerosis,” was published in the journal Brain. Relapses and…

Genetic variants may contribute to increased levels of antibodies against proteins of the Epstein-Barr virus — a known environmental risk factor for multiple sclerosis (MS) — in MS patients and their siblings, a study suggests. The study, “EBNA-1 titer gradient in families with multiple sclerosis indicates a…

Inflammatory lesions within the brain, called paramagnetic rim lesions, visible on imaging scans may improve the accuracy of a multiple sclerosis (MS) diagnosis, especially when used in combination with other imaging-based biomarkers, a  study reported. If corroborated in larger future studies, these white matter lesions may serve as an early…

Anacardic acid, a compound found in cashew nuts, promoted myelin regeneration and eased neuronal damage and disability in two mouse models of multiple sclerosis (MS). These protective effects were associated with maturation of myelin-producing cells and production of IL-33, an immune-related molecule with a neuroreparative role in the central…

In people with multiple sclerosis (MS), skin cells show increased amounts of cellular stress in a manner that is distinct from people without MS and from other neurological diseases, new research shows. The findings were published in the journal Aging, in the study “Signatures of cell…

In a $3.68 billion transaction, Sanofi is preparing to acquire Principia Biopharma, a biopharmaceutical company focused on the development of therapies for disorders caused by dysregulation of the immune system, including multiple sclerosis (MS). The decision was unanimously approved by the board of directors of…

A protein known as Gsta4 is critical in the growth and activity of oligodendrocytes, a special type of brain cell that generates the myelin sheath that is damaged in multiple sclerosis (MS), a study shows. The overproduction of Gsta4 in…

Lowering levels of a protein called reelin — which regulates how permeable blood vessels are to immune cells — reduced infiltration of these cells into the central nervous system (CNS), preventing neuroinflammation and disease progression in a mouse model of multiple sclerosis (MS). These data, which also showed that Reelin…

Almost two-thirds of people newly diagnosed with multiple sclerosis (MS) in the United States, identified through a national database, were not prescribed disease-modifying therapies (DMTs) over an average of more than two years of follow-up, a real-world study of nearly 5,700 patients found. Current guidelines “recommend early treatment with…

Multiple sclerosis (MS) patients have high levels of cortisol, a stress hormone, compared to healthy controls. Also, patients categorized as non-cognitive fatigue show a higher variability in cortisol levels and perform worse on an attention task. Those findings are documented in the study, “Relation between cognitive fatigue and circadian…

Inflammation drives the loss of brain volume and thinning of the eye’s retina in the first five years of a multiple sclerosis (MS) diagnosis, an imaging study demonstrates.  The findings support a therapeutic strategy of halting inflammatory activity during this initial period. …

For the first time, scientists have shown that a protein known as CD36 on the surface of some immune cells is crucial for clearing myelin debris and suppressing nerve cell inflammation in disorders such as multiple sclerosis (MS), according to a new…

Therapeutics Solutions International has announced filing a new patent covering the memory protective effects of its natural nutritional supplement QuadraMune, as seen in an animal model of memory loss caused by inflammation. QuadraMune is a nutritional supplement, available in capsule form, made of four ingredients with known anti-inflammatory, neuroprotective, and…

Cigarette smoking and an Epstein–Barr virus infection together represent a significant risk factor for multiple sclerosis (MS), suggesting that at least one path to this disease involves two factors working synergistically, a study reports. The study, “Smoking and Epstein–Barr virus infection in multiple sclerosis development,” was published…

A $41,000 fellowship from the National Institutes of Health (NIH) aims to advance research into how changes in brain connectivity are related to the cognitive deficits seen in people with multiple sclerosis (MS). The Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship was granted to…

Immigrants with multiple sclerosis (MS) in Ontario use public health services as much as long-term residents, but are more likely to be hospitalized during the year in which they are diagnosed, according to a recent study. While reasons for that year’s higher hospitalization rates are not clear, evidence supports…

People with multiple sclerosis (MS) who exercise regularly are able to maintain volume in the hippocampus, a brain region responsible for learning and memory, a study reports. This work “adds to the growing body of evidence that exercise has many benefits for people with MS,” the National MS…

The debilitating mental fatigue that people with multiple sclerosis (MS) can feel after a cognitively demanding task may be due to less efficient use of the brain, a pilot study that mapped brain activity during tasks suggests. The study “Neural mechanisms underlying state mental fatigue in multiple sclerosis: a…

A “prudent” diet rich in fresh fruit, non-fried fish, whole grains, vegetables, and nuts may lower the likelihood of a relapse in people with a first demyelinating event, a major risk factor for multiple sclerosis (MS), a study in Australia suggests. While the researchers did not find a strong link…

Levels of a protein linked to inflammation and neurodegeneration in multiple sclerosis (MS) — called chitinase 3-like-1 (CHI3L1) — may prove to be a cerebrospinal fluid biomarker of neurologic disability in primary progressive MS (PPMS), a pilot study suggests. Higher CHI3L1 levels at PPMS diagnosis showed a…