risk factors

A variant in the TYK2 gene, which encodes an immune system protein, may work to protect people from autoimmune disorders, including multiple sclerosis (MS), without overly depressing the body’s ability to fight opportunistic infections, researchers at the University of Oxford report. Their study, “Resolving TYK2 Locus Genotype-To-Phenotype Differences In Autoimmunity,” was published…

Multiple sclerosis (MS), especially in premenopausal women, does  not seem to be associated with breast cancer, as suggested in previous studies, researchers reported. And, they argue, the higher incidences of this cancer in postmenopausal women with MS may be due more to surveillance bias than true risk. These findings were detailed in the study, “…

A genome-wide analysis of over 110,000 people allowed researchers with the International Multiple Sclerosis Genetics Consortium (IMSGC) to discover 200 genetic loci (the position of genes on a chromosome) that are common to people with multiple sclerosis (MS). The findings were given in the presentation, “200 loci complete the genetic puzzle of multiple sclerosis,” by Dr. Nikolaos…

My neurologist calls Lemtrada “HSCT lite.”  She says that not only is the drug able to reduce exacerbations and limit the overall progression of multiple sclerosis, it’s actually reversed some symptoms in some of her patients.   I guess I’m going to find out if she’s right about…

I made a trip to the dentist today. What does that have to do with multiple sclerosis, you ask? Stay with me. We’ll get there. But first, let me tell you about a weekend conference that my local chapter of the National Multiple Sclerosis Society held recently. One of…

Osteoporosis (fragile bones) is only a women’s problem, right? Wrong, especially if you have multiple sclerosis — as I’ve discovered. Osteoporosis causes bones to become weak and brittle.  A fall that probably wouldn’t harm a healthy person can easily break the bone of someone with osteoporosis.  When the…

In a large prospective study with validated measures of physical activity, researchers found no evidence that exercise reduced a woman’s risk of developing multiple sclerosis (MS). Although physical activity is known to have numerous health benefits, it seems unlikely to protect a person against the likelihood of developing MS, the study concludes. The study, published…

Exposure to heavy metals and being female are associated with a higher incidence of multiple sclerosis (MS), according to a study conducted by Maria Cristina Monti and colleagues from two Italian universities. The study, “Is Geo-Environmental Exposure a Risk Factor for Multiple Sclerosis? A Population-Based Cross-Sectional Study in South-Western Sardinia,” was…

Life can be really strange and not always fathomable to someone like me who is not blessed with neither medical nor scientific qualifications. On a purely technical basis, I am just an ordinary guy. What I do know about diseases, illnesses and conditions – call them what you will –…

In a large nationwide study in Finland, researchers found evidence supporting the link between vitamin D deficiency and an increased risk for multiple sclerosis (MS) in women. The results were given in an oral presentation, “Serum levels of 25-hydroxyvitamin D and risk of multiple sclerosis among women in the Finnish Maternity Cohort,”…

The importance of getting a representative group of people, also known as subjects, engaged in  clinical trials cannot be understated. There is so much that we need to know when it comes to multiple sclerosis, but the picture cannot be complete unless the cohort of subjects includes people from…

Early detection is very important for any disease diagnosis. With Multiple Sclerosis, it gives you the opportunity to start a treatment plan early that may help with slowing the progression of the disease. Symptoms of MS vary widely from person to person and can closely mimic other disease symptoms. Lesions don’t always…

Here’s my Pick of the Week’s News, as published in Multiple Sclerosis News Today. Gilenya-like Therapy Shows Benefit in Secondary Progressive MS Patients in Phase 3 Trial Here’s a potentially encouraging development for anyone with SPMS. Patients with secondary progressive multiple sclerosis (SPMS) who were treated with BAF312 (siponimod),…

Obese children and young adults appear to be at a considerably higher risk of developing multiple sclerosis (MS), according to researchers at the McGill University in Canada and collaborators at the University of Bristol in the U.K., who found a causal relationship between the two. Their study, “…

High blood pressure may be linked to greater overall disability in people with multiple sclerosis (MS), although the rate at which disability progresses might be slower than in patients without hypertension, a retrospective study concludes. The research, involving a large number of MS patients, helps to clarify a rather confusing range of views on how…

In my mind, MS is linked to glandular fever. From personal experience, there is no room for doubt of any kind. Trouble is, though, that my experience and belief is not proof. And that is why I find that efforts to establish a definite link between glandular fever, often known…

In the largest genetic study ever performed in a single country, scientists in Germany discovered four new risk genes for multiple sclerosis (MS). The genes, altered in MS patients, are involved in the control of how other genes are activated through mechanisms known as epigenetics. The discovery advances understanding of how…

Processed foods have been added to the list of “no-no” items that we are not supposed to eat if you, like me, are unfortunate enough to have MS. We were already warned against gluten, salt and various other ingredients in our diet; now it’s processed foods and additives. This is…

Autologous haematopoietic stem cell transplantation (aHSCT) has been used to stop autoimmune processes in multiple sclerosis (MS), although the treatment is not effective for every person. Now, an improved version of the technique is showing astonishingly good results, with patients free of both the need for treatment and the risk of relapses for…

Some forms of multiple sclerosis are hereditary after all. After many years of saying that MS is not passed down the generations, new research now says the opposite. Although past studies have suggested that genetic risk factors could increase the risk of developing the disease, up until now, there has been…

A mutation in a mouse model of the John Cunningham (JC) virus, which causes progressive multifocal leukoencephalopathy (PML), allows the virus to evade the host immune responses in people with multiple sclerosis (MS), according to a study into the mechanisms of PML. Infection with the JC virus most often passes unnoticed in healthy…

Previous studies suggested that multiple sclerosis (MS) and Hodgkin lymphoma might share underlying causes, including exposure to microorganisms in childhood, such as Epstein-Barr virus (EBV) infection. In the study “Multiple sclerosis and risk of young-adult-onset Hodgkin lymphoma,” published in the journal Neurology: Neuroimmunology and Neuroinflammation, researchers suggested that…

Researchers investigating immune B-cell response to the Epstein-Barr virus (EBV) and cytomegalovirus (CMV) found that it may correlate with the amount of brain-specific B-cells in the blood — a marker of multiple sclerosis (MS) — and with higher disease activity. The findings were published in the journal Viruses, in…

Mitoxantrone,  a multiple sclerosis (MS)  drug that is already associated with a higher risk for leukemia and heart damage, may also raise a person’s risk of colorectal cancer, researchers at the University of Würzburg, in Germany, reported. If confirmed in larger studies, the findings indicate that colonoscopies should be conducted on MS patients after…

A systematic review of existing medical literature on multiple sclerosis (MS) could shed light on MS causes and predictors for disease progression, and on lifestyle changes — ranging from vitamin D intake to weight loss — that might reduce a person’s risk. The report, “Factors associated with onset, relapses…

A team of researchers suggested that cigarette smoking is associated with adverse effects to white matter in the brain, and reported that smoking may underlie the clinical course of clinically isolated syndrome, an early and potentially predictive symptom of a progression to multiple sclerosis (MS). The study, “Influence of cigarette smoking on white matter in patients with…

The National Multiple Sclerosis Society is funding a new survey to understand how people living with multiple sclerosis (MS) weigh risks against benefits when choosing MS therapies. The survey was developed by Dr. Robert Fox, a neurologist, working with colleagues at the Cleveland Clinic and the MS patient…

A case report of a woman with relapsing-remitting multiple sclerosis (RRMS) who developed shingles while being treated with dimethyl fumarate (Tecfidera) has raised questions of whether the drug reactivates the varicella-zoster virus. The study, “Disseminated zoster with paresis in a multiple sclerosis patient treated with dimethyl fumarate,“ was published in…

According to new research published in the Multiple Sclerosis Journal, environmental factors appear to play a much greater role in the onset of multiple sclerosis (MS) than previously recognized. The study, “Ethnicity and prevalence of multiple sclerosis in east London,” was led by scientists at…

Certain therapies used to treat multiple sclerosis (MS) have been associated with opportunistic infections of the central nervous system, including progressive multifocal leukoencephalopathy (PML), a rare but often fatal brain disorder caused by the John Cunningham (JC) virus. The question of whether the risk for opportunistic infections to MS patients outweighs…